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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Cvib_1756
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000006700 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalUniRule annotationAdd BLAST21
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Transmembranei94 – 114HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei169 – 189HelicalUniRule annotationAdd BLAST21
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei237 – 257HelicalUniRule annotationAdd BLAST21
Transmembranei264 – 284HelicalUniRule annotationAdd BLAST21
Transmembranei289 – 309HelicalUniRule annotationAdd BLAST21
Transmembranei344 – 364HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000745521 – 367Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST367

Interactioni

Protein-protein interaction databases

STRINGi290318.Cvib_1756.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A4SH05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYLLKYIN EVFDPPGLGV IEYLTFRASA AAITALLITL VAGPGFIALL
60 70 80 90 100
RARFIEPVKE EAPPEHRKKK LPTMGGLLII ISVEVSVLLW AKFTDPHVWL
110 120 130 140 150
IMLALLWMGV IGFIDDYSKV VLKVKGGLSA RWKLVGQISL GLVVGIYTSM
160 170 180 190 200
DPVFSVLMRE TTVPFFKNLT IDYGIFYVPV VIFIITALSN AVNLTDGLDG
210 220 230 240 250
LAAGSSAIVI FGLGGFAYLA GNVVYASYLS IPFIPGGGEI AVVCMAATMA
260 270 280 290 300
CVGFLWFNAN PAEIIMGDTG SLALGSTIAV TALLIKQELL LPVLGGLFFL
310 320 330 340 350
ETLSVSLQVL YFKYTRMRFG EGRRIFLMAP LHHHFQLKGW AEQKIVIRFW
360
IVTILLFLTS LMTLKLR
Length:367
Mass (Da):40,320
Last modified:May 15, 2007 - v1
Checksum:iD7D81C750039864F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA. Translation: ABP37764.1.
RefSeqiWP_011890986.1. NC_009337.1.

Genome annotation databases

EnsemblBacteriaiABP37764; ABP37764; Cvib_1756.
KEGGipvi:Cvib_1756.

Similar proteinsi

Entry informationi

Entry nameiMRAY_CHLPM
AccessioniPrimary (citable) accession number: A4SH05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: June 7, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families