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Protein

NAD kinase

Gene

nadK

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorUniRule annotation1
Binding sitei148NADUniRule annotation1
Binding sitei165NADUniRule annotation1
Binding sitei167NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 67NADUniRule annotation2
Nucleotide bindingi137 – 138NADUniRule annotation2
Nucleotide bindingi178 – 183NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHA290318:G1G8E-1776-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Cvib_1693
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000006700 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000795051 – 281NAD kinaseAdd BLAST281

Interactioni

Protein-protein interaction databases

STRINGi290318.Cvib_1693

Structurei

3D structure databases

ProteinModelPortaliA4SGU4
SMRiA4SGU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A4SGU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGIVVNVS RQSAIDLARR LARWLDERKV DYVFESLSAE KTGSHRSAPI
60 70 80 90 100
EELNTQCDAF ISLGGDGTLL FTSQHSVTKP VIGVNVGRLG FLAEFSPEEM
110 120 130 140 150
LPAVERFLNG DYSIHTRSQL EAGLLTNGSP EHFRALNDVV IEKGTYPRIP
160 170 180 190 200
AFIIKLDGEL LSSYRADGII IATSTGSTAY SMSAGGPIIA PKSSVVVITP
210 220 230 240 250
ICPHMLTVRP IVISDEKSIE VSVDAPDGAF PLNCDGHLRK MLAPQEVVTI
260 270 280
KKSSQSINLV ANSSRDYCEV LRTKLLWGRE A
Length:281
Mass (Da):30,539
Last modified:May 15, 2007 - v1
Checksum:i62B8EBE841F86933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA Translation: ABP37703.1
RefSeqiWP_011890926.1, NC_009337.1

Genome annotation databases

EnsemblBacteriaiABP37703; ABP37703; Cvib_1693
KEGGipvi:Cvib_1693

Similar proteinsi

Entry informationi

Entry nameiNADK_CHLPM
AccessioniPrimary (citable) accession number: A4SGU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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