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A4SGR6

- A4SGR6_PROVI

UniProt

A4SGR6 - A4SGR6_PROVI

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Protein
ATP-dependent 6-phosphofructokinase
Gene
pfkA, Cvib_1665
Organism
Prosthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461ATP; via amide nitrogen By similarityUniRule annotation
Metal bindingi138 – 1381Magnesium; catalytic By similarityUniRule annotation
Active sitei163 – 1631Proton acceptor By similarityUniRule annotation
Binding sitei190 – 1901Allosteric activator ADP By similarityUniRule annotation
Binding sitei198 – 1981Substrate; shared with dimeric partner By similarityUniRule annotation
Binding sitei258 – 2581Substrate By similarityUniRule annotation
Binding sitei282 – 2821Substrate; shared with dimeric partner By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1082ATP By similarityUniRule annotation
Nucleotide bindingi137 – 1404ATP By similarityUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHA290318:GHNQ-1713-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkAUniRule annotation
Ordered Locus Names:Cvib_1665Imported
OrganismiProsthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))Imported
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000006700: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi290318.Cvib_1665.

Structurei

3D structure databases

ProteinModelPortaliA4SGR6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 605Allosteric activator ADP binding; shared with dimeric partner By similarityUniRule annotation
Regioni161 – 1633Substrate binding By similarityUniRule annotation
Regioni205 – 2073Substrate binding By similarityUniRule annotation
Regioni221 – 2233Allosteric activator ADP binding By similarityUniRule annotation
Regioni288 – 2914Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0205.
HOGENOMiHOG000248870.
KOiK00850.
OMAiGFGGRCV.
OrthoDBiEOG644ZRM.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4SGR6-1 [UniParc]FASTAAdd to Basket

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MKGQPRLRES RTLHPPMATM TRKSDNDQLS FTSGRIKKIG ILTSGGDAPG    50
MNAAIRAATR SAIAAGREAV GILRGYQGMI DGDFIPLQST DVSGILQLGG 100
TMLKTARCKE FRTPEGRRRA KEQLTAAAID AVIVIGGDGS FTGAWVMSQE 150
CDIPFVGIPA TIDNDMYGTD YTIGYETALN SVVCAVDKIK DTARSHGRIF 200
FIEVMGHEAG LLALNSGIAC GAEVILIPES KAQHEELQKF LEKGYRDKES 250
SGIVMVAEGD EAGGALHIAE QIRRDHPDLD VRISILGHIQ RGGSPVARDR 300
INATRMGIAA VDALLNDQKS IMIGLDNNRI VHVTFNKAVK MNHSIDTGLL 350
EVHNLLNGM 359
Length:359
Mass (Da):38,658
Last modified:May 15, 2007 - v1
Checksum:i9F7F93EA3913ECE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000607 Genomic DNA. Translation: ABP37675.1.
RefSeqiYP_001131177.1. NC_009337.1.

Genome annotation databases

EnsemblBacteriaiABP37675; ABP37675; Cvib_1665.
GeneIDi4970059.
KEGGipvi:Cvib_1665.
PATRICi21397866. VBIChlPha132153_1750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000607 Genomic DNA. Translation: ABP37675.1 .
RefSeqi YP_001131177.1. NC_009337.1.

3D structure databases

ProteinModelPortali A4SGR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290318.Cvib_1665.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP37675 ; ABP37675 ; Cvib_1665 .
GeneIDi 4970059.
KEGGi pvi:Cvib_1665.
PATRICi 21397866. VBIChlPha132153_1750.

Phylogenomic databases

eggNOGi COG0205.
HOGENOMi HOG000248870.
KOi K00850.
OMAi GFGGRCV.
OrthoDBi EOG644ZRM.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci CPHA290318:GHNQ-1713-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Prosthecochloris vibrioformis DSM 265."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Schuster S.C., Bryant D.A., Richardson P.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 265Imported.

Entry informationi

Entry nameiA4SGR6_PROVI
AccessioniPrimary (citable) accession number: A4SGR6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

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