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A4SGR6

- A4SGR6_PROVI

UniProt

A4SGR6 - A4SGR6_PROVI

Protein

ATP-dependent 6-phosphofructokinase

Gene

pfkA

Organism
Prosthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation

    Enzyme regulationi

    Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461ATP; via amide nitrogenUniRule annotation
    Metal bindingi138 – 1381Magnesium; catalyticUniRule annotation
    Active sitei163 – 1631Proton acceptorUniRule annotation
    Binding sitei190 – 1901Allosteric activator ADPUniRule annotation
    Binding sitei198 – 1981Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei258 – 2581SubstrateUniRule annotation
    Binding sitei282 – 2821Substrate; shared with dimeric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi107 – 1082ATPUniRule annotation
    Nucleotide bindingi137 – 1404ATPUniRule annotation

    GO - Molecular functioni

    1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fructose 6-phosphate metabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPHA290318:GHNQ-1713-MONOMER.
    UniPathwayiUPA00109; UER00182.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
    Short name:
    ATP-PFKUniRule annotation
    Short name:
    PhosphofructokinaseUniRule annotation
    Alternative name(s):
    PhosphohexokinaseUniRule annotation
    Gene namesi
    Name:pfkAUniRule annotation
    Ordered Locus Names:Cvib_1665Imported
    OrganismiProsthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))Imported
    Taxonomic identifieri290318 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
    ProteomesiUP000006700: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. 6-phosphofructokinase complex Source: InterPro

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi290318.Cvib_1665.

    Structurei

    3D structure databases

    ProteinModelPortaliA4SGR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni56 – 605Allosteric activator ADP binding; shared with dimeric partnerUniRule annotation
    Regioni161 – 1633Substrate bindingUniRule annotation
    Regioni205 – 2073Substrate bindingUniRule annotation
    Regioni221 – 2233Allosteric activator ADP bindingUniRule annotation
    Regioni288 – 2914Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade "B1" sub-subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0205.
    HOGENOMiHOG000248870.
    KOiK00850.
    OMAiGFGGRCV.
    OrthoDBiEOG644ZRM.

    Family and domain databases

    HAMAPiMF_00339. Phosphofructokinase.
    InterProiIPR012003. ATP_PFK_prok.
    IPR012828. PFKA_ATP.
    IPR022953. Phosphofructokinase.
    IPR015912. Phosphofructokinase_CS.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view]
    PfamiPF00365. PFK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSiPR00476. PHFRCTKINASE.
    SUPFAMiSSF53784. SSF53784. 1 hit.
    TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
    PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4SGR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGQPRLRES RTLHPPMATM TRKSDNDQLS FTSGRIKKIG ILTSGGDAPG    50
    MNAAIRAATR SAIAAGREAV GILRGYQGMI DGDFIPLQST DVSGILQLGG 100
    TMLKTARCKE FRTPEGRRRA KEQLTAAAID AVIVIGGDGS FTGAWVMSQE 150
    CDIPFVGIPA TIDNDMYGTD YTIGYETALN SVVCAVDKIK DTARSHGRIF 200
    FIEVMGHEAG LLALNSGIAC GAEVILIPES KAQHEELQKF LEKGYRDKES 250
    SGIVMVAEGD EAGGALHIAE QIRRDHPDLD VRISILGHIQ RGGSPVARDR 300
    INATRMGIAA VDALLNDQKS IMIGLDNNRI VHVTFNKAVK MNHSIDTGLL 350
    EVHNLLNGM 359
    Length:359
    Mass (Da):38,658
    Last modified:May 15, 2007 - v1
    Checksum:i9F7F93EA3913ECE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000607 Genomic DNA. Translation: ABP37675.1.
    RefSeqiYP_001131177.1. NC_009337.1.

    Genome annotation databases

    EnsemblBacteriaiABP37675; ABP37675; Cvib_1665.
    GeneIDi4970059.
    KEGGipvi:Cvib_1665.
    PATRICi21397866. VBIChlPha132153_1750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000607 Genomic DNA. Translation: ABP37675.1 .
    RefSeqi YP_001131177.1. NC_009337.1.

    3D structure databases

    ProteinModelPortali A4SGR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290318.Cvib_1665.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP37675 ; ABP37675 ; Cvib_1665 .
    GeneIDi 4970059.
    KEGGi pvi:Cvib_1665.
    PATRICi 21397866. VBIChlPha132153_1750.

    Phylogenomic databases

    eggNOGi COG0205.
    HOGENOMi HOG000248870.
    KOi K00850.
    OMAi GFGGRCV.
    OrthoDBi EOG644ZRM.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00182 .
    BioCyci CPHA290318:GHNQ-1713-MONOMER.

    Family and domain databases

    HAMAPi MF_00339. Phosphofructokinase.
    InterProi IPR012003. ATP_PFK_prok.
    IPR012828. PFKA_ATP.
    IPR022953. Phosphofructokinase.
    IPR015912. Phosphofructokinase_CS.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view ]
    Pfami PF00365. PFK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSi PR00476. PHFRCTKINASE.
    SUPFAMi SSF53784. SSF53784. 1 hit.
    TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
    PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Prosthecochloris vibrioformis DSM 265."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Schuster S.C., Bryant D.A., Richardson P.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 265Imported.

    Entry informationi

    Entry nameiA4SGR6_PROVI
    AccessioniPrimary (citable) accession number: A4SGR6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzymeUniRule annotation, Complete proteomeImported

    External Data

    Dasty 3