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Protein

Homoserine kinase

Gene

thrB

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Cvib_1702)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. no protein annotated in this organism
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 110ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHA290318:G1G8E-1711-MONOMER
UniPathwayiUPA00050; UER00064

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:Cvib_1629
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000006700 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000801261 – 320Homoserine kinaseAdd BLAST320

Proteomic databases

PRIDEiA4SGN0

Interactioni

Protein-protein interaction databases

STRINGi290318.Cvib_1629

Structurei

3D structure databases

ProteinModelPortaliA4SGN0
SMRiA4SGN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RDY Bacteria
COG0083 LUCA
HOGENOMiHOG000247197
KOiK00872
OMAiPDNVAPC
OrthoDBiPOG091H020X

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
HAMAPiMF_00384 Homoser_kinase, 1 hit
InterProiView protein in InterPro
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR000870 Homoserine_kinase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR20861:SF1 PTHR20861:SF1, 1 hit
PfamiView protein in Pfam
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF000676 Homoser_kin, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00191 thrB, 1 hit
PROSITEiView protein in PROSITE
PS00627 GHMP_KINASES_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

A4SGN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVRGFASA TVGNVACGFD ILGFAITEPG DEVILTRSER KHTGCPVTIS
60 70 80 90 100
SISGDGGKLP LDPRKNTSSF VVLKFLEHIR THKGQDCTGH ISLELKKHLP
110 120 130 140 150
LSSGMGSSAA SAAAALAAAN ELLGRPCTKM ELVHFAIEGE RVACGSAHAD
160 170 180 190 200
NAAPAILGNF VLIRSYTPLD LIVIPPPEKL FCSLVHPHTE LRTSFARSVL
210 220 230 240 250
PTDITLKDAT RQWGNVGALV AGLLTSDYAL VGRSLVDVVA EPKRAPLIPG
260 270 280 290 300
FAEVKEAALN AGALGCSIAG SGPSIFAFSD SAETAHAAGE AMQKAFLASK
310 320
KSLKSDMWVS PICREGARIL
Length:320
Mass (Da):33,507
Last modified:May 15, 2007 - v1
Checksum:iCBA5FE0AE4580079
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA Translation: ABP37639.1
RefSeqiWP_011890862.1, NC_009337.1

Genome annotation databases

EnsemblBacteriaiABP37639; ABP37639; Cvib_1629
KEGGipvi:Cvib_1629

Similar proteinsi

Entry informationi

Entry nameiKHSE_CHLPM
AccessioniPrimary (citable) accession number: A4SGN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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