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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei280ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Cvib_1503
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000006700 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677391 – 521Glutamate--tRNA ligaseAdd BLAST521

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290318.Cvib_1503.

Structurei

3D structure databases

ProteinModelPortaliA4SGA5.
SMRiA4SGA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 40"HIGH" regionUniRule annotationAdd BLAST11
Motifi277 – 281"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20. Bacteria.
COG0008. LUCA.
HOGENOMiHOG000252720.
KOiK01885.
OMAiAYYAFDT.
OrthoDBiPOG091H021W.

Family and domain databases

CDDicd00808. GluRS_core. 1 hit.
Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00022. Glu_tRNA_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR033910. GluRS_core.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A4SGA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTDGSSLN SLTMTRRMMV GKRVRTRFAP SPTGYLHVGG LRTALYNYLF
60 70 80 90 100
AKRMDGDFVV RIEDTDQSRK VADAQENLIK TLEWAGLMPD ESPLHGGDFG
110 120 130 140 150
PYLQSERLDI YKKYCEQLLE AGHAYHCFAT SEELEENRQL QLKQGLQPKY
160 170 180 190 200
NRKWLPEDMG GSMPRSEIQK KLDEGVPSVV RMKVPDYVSV WFEDIIRGPI
210 220 230 240 250
EFDSATIDDQ VLMKSDGFPT YHFASVIDDH LMEFTHIIRG EEWLPSMPKH
260 270 280 290 300
LLLYEFLGWE PPKYAHLPLL LNPDRSKLSK RQGDVSVEDY IRKGYSGEAI
310 320 330 340 350
VNFVALLGWN QGEGCEQEVY SLQELTERFS LERVGKAGSI FTIDKLNWLE
360 370 380 390 400
KQYIKNRPAE DIIRVIKPLL LSELEKKETL LDPATITGER YLEDVIELMR
410 420 430 440 450
ERVGFEREFV TFSSYFFFEP ETYEEDAVKK RWTPDTNSLL DEFLPVLESM
460 470 480 490 500
PDFTAEAIEA ALKEFVAPKG LKAAALIHPL RIVSSGVSFG PSLYHMLEVL
510 520
GREAVVRRIR KGMAVITLPQ Q
Length:521
Mass (Da):59,828
Last modified:May 15, 2007 - v1
Checksum:iAE751037843FB84D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA. Translation: ABP37514.1.

Genome annotation databases

EnsemblBacteriaiABP37514; ABP37514; Cvib_1503.
KEGGipvi:Cvib_1503.

Similar proteinsi

Entry informationi

Entry nameiSYE_CHLPM
AccessioniPrimary (citable) accession number: A4SGA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 15, 2007
Last modified: February 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome