A4SG83 (HIS3_PROVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	Cvib_1481

Organism

Prosthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265)) [Complete proteome] [HAMAP]

Taxonomic identifier

290318 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium › Chlorobium phaeovibrioides

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP-Rule MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP-Rule MF_01021
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 137	137	Phosphoribosyl-AMP cyclohydrolase HAMAP-Rule MF_01021		PRO_1000084183

Sequences

	Sequence		Length	Mass (Da)
	A4SG83 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: F7D5117C53C40A32	FASTA	137	15,705
	10 20 30 40 50 60 MGENEGIDKS FLDTVKFDDR GLIPAIVQDH ETGKVLMMAW MNRESLEMTL ERKKACYWSR 70 80 90 100 110 120 SRNKLWLKGE SSGNMQEVFD ILIDCDGDTL ILKVSQIGGA CHVGYHSCFY RKVNEDGSMQ 130 ICDTLMFNPE EVYGKKH

References

[1]

"Complete sequence of Prosthecochloris vibrioformis DSM 265." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Schuster S.C., Bryant D.A., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 265.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000607 Genomic DNA. Translation: ABP37492.1.
RefSeq	YP_001130994.1. NC_009337.1.
3D structure databases
ProteinModelPortal	A4SG83.
SMR	A4SG83. Positions 22-116.
ModBase	Search...
Protein-protein interaction databases
STRING	290318.Cvib_1481.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABP37492; ABP37492; Cvib_1481.
GeneID	4970236.
KEGG	pvi:Cvib_1481.
PATRIC	21397466. VBIChlPha132153_1559.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0139.
HOGENOM	HOG000277504.
KO	K01496.
OMA	GACHVGY.
ProtClustDB	PRK00051.
Enzyme and pathway databases
BioCyc	CPHA290318:GHNQ-1531-MONOMER.
UniPathway	UPA00031; UER00008.
Family and domain databases
HAMAP	MF_01021. HisI.
InterPro	IPR026660. PRA-CH. IPR002496. PRib_AMP_CycHydrolase_dom. [Graphical view]
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_PROVI

Accession

Primary (citable) accession number: A4SG83

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 15, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program