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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHA290318:G1G8E-1496-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Cvib_1425
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000006700 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000748391 – 805Leucine--tRNA ligaseAdd BLAST805

Interactioni

Protein-protein interaction databases

STRINGi290318.Cvib_1425

Structurei

3D structure databases

ProteinModelPortaliA4SG27
SMRiA4SG27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A4SG27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYDFSKTEK KWQARWKQQE TFKTGEAPEK PKYYVLDMFP YPSGSGLHVG
60 70 80 90 100
HLEGYTASDI SARYRRSRGY NVLHPMGWDA FGLPAEQFAI KTGTHPSDTT
110 120 130 140 150
QKNIANFKET LQAMGFSYDW SREINTTDPG YFQWTQWIFL KLHEMGLAYM
160 170 180 190 200
SEVDVNWCVE LRAVLANEEV EEKLADGLTV VRRPLRQWVL KITAYADRLL
210 220 230 240 250
EDLDGLDWPE NVKQMQRNWI GRSEGVEVDF ELRCHRTMLR VYTTRPDTLF
260 270 280 290 300
GATYLVISPE HAMAEKLATA QQLVAVKEYI AKAKLKTELE RTGLQKDKTG
310 320 330 340 350
VFTGSYAINP ATGEPLPVWI SDFVLTSYGT GAIMSVPAHD SRDWEFAKQY
360 370 380 390 400
GLPIIEVVKS PHDVQQEVFE GKDSTVVNSS NNDISLNGLA FPEAFELMAS
410 420 430 440 450
WLEKKKAGKR KVNYRLRDWI FSRQRYWGEP IPIKHYPDGT LKPETSLPLM
460 470 480 490 500
LPEVEAYQPT ETGESPLANI PEWLNGTDEN GPFRRETNTM PQWAGSCWYY
510 520 530 540 550
LRFIDPHNSK LPVDPAKEAY WMNVDLYIGG AEHAVLHLLY ARFWHKVLFD
560 570 580 590 600
LKVVSTKEPF QRLFNQGMIL GEDNEKMSKS RGNVIPADHV LQTYGADAVR
610 620 630 640 650
LYEMFLGPLE QVKPWNTNGI EGISRFLSRV WRLVWPEPEG TRADLSTLAP
660 670 680 690 700
SPDLLRRMHK TIKKVAADTE NLKFNTAIAE MMVFTNELHR TGEGSRIAVE
710 720 730 740 750
TLLLLLAPYA PHLSEELWEA LGHQESISLA PFPEFDPELA QDKEVTIAVQ
760 770 780 790 800
VNGKLRGSFT AAPGSPKEQL LNEAKALEGV KKFLEGVTIM KEIVVPDKLI

NFAVK
Length:805
Mass (Da):91,792
Last modified:May 15, 2007 - v1
Checksum:iEA7A3A78D650EE00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA Translation: ABP37436.1
RefSeqiWP_011890659.1, NC_009337.1

Genome annotation databases

EnsemblBacteriaiABP37436; ABP37436; Cvib_1425
KEGGipvi:Cvib_1425

Similar proteinsi

Entry informationi

Entry nameiSYL_CHLPM
AccessioniPrimary (citable) accession number: A4SG27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health