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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciCPHA290318:G1G8E-1475-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Cvib_1404
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000006700 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000832231 – 443Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST443

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi290318.Cvib_1404

Structurei

3D structure databases

ProteinModelPortaliA4SG06
SMRiA4SG06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEM Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A4SG06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIINTDSD RAEMLAAAGA ASFNDLIADI PEEIRLKKSL DLAPALDEMA
60 70 80 90 100
VRRQLESLAA RNRSTAGYVS FLGGGAYDQF IPSAIRAIVS RSEFYTAYTP
110 120 130 140 150
YQAEVSQGTL QAIYEYQSLI CRLYGMDVAN ASMYDGATAL AEAALMAMNV
160 170 180 190 200
TGKERIVVAG QLHPWNSSVL STYLGAAGHS PVVQNSVEEG VGSIASLRGM
210 220 230 240 250
VDGTVAAVIV QQPNFYGCLE DVEAIGAIAR EAGALFIVSA DPHSLGVLEA
260 270 280 290 300
PGAYGADIAV GEGQPLGSAQ SFGGPYLGIF TVREKFVRKI PGRLVGMTKD
310 320 330 340 350
RDGRDGFILT LQTREQHIRR EKATSNICTN QALNALQAAV YLSLLGRQGM
360 370 380 390 400
QEVAGQSLER AHYLAARIVE IPGYSLRFSA PFFREFVLNT PVHPAVIVER
410 420 430 440
MLEEGIFAGI DLSVFGDEGL LVSVTEKRTK EEMDRFALLL SSF
Length:443
Mass (Da):47,720
Last modified:May 15, 2007 - v1
Checksum:i7DF81451CE9646F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA Translation: ABP37415.1
RefSeqiWP_011890638.1, NC_009337.1

Genome annotation databases

EnsemblBacteriaiABP37415; ABP37415; Cvib_1404
KEGGipvi:Cvib_1404

Similar proteinsi

Entry informationi

Entry nameiGCSPA_CHLPM
AccessioniPrimary (citable) accession number: A4SG06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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