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A4SFC7 (A4SFC7_PROVI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) By similarity. SAAS SAAS002034 HAMAP-Rule MF_01025

Catalytic activity

Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA. SAAS SAAS005671 HAMAP-Rule MF_01025

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4. SAAS SAAS002034 HAMAP-Rule MF_01025

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01025 SAAS SAAS002034

Sequence similarities

Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. HAMAP-Rule MF_01025

Sequences

Sequence LengthMass (Da)Tools
A4SFC7 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 6CD82B622BF446F6

FASTA52256,579
        10         20         30         40         50         60 
MKENILVFDT TLRDGEQSPG ASLNVQEKVE IARQLEKLGV DIIEAGFPAS SPLQLEAVQR 

        70         80         90        100        110        120 
ISDESGVVIA ALSRAVENDI KASWTALKGA KKPRIHTFIS TSDIHIAGKF AGDRYGRTLE 

       130        140        150        160        170        180 
EKRRTILKMA VDAVAFAKTF TSDIEFSAED AGRTDPGYLA EITEAVISAG ATTVNIPDTT 

       190        200        210        220        230        240 
GYTWPSEFGR KIADLISRVP NSGNAIISVH CHNDLGLAVA NSLSALENGA RQVECSINGI 

       250        260        270        280        290        300 
GERAGNASLE EIVMALKVRS DLHNFQTGIV TEEIYRTSRM VSGFTGIIVQ PNKAIVGENA 

       310        320        330        340        350        360 
FSHESGIHQD GMLKNRQTYE VMTPESVGVP KTSIVLGRHS GKHGLKARLE ALGYTLADEE 

       370        380        390        400        410        420 
LESVYRRFME IADKKKEVYD DDLRVLMGDE LGKPSTAFVL DYLHINSGTA SIPTATVRIR 

       430        440        450        460        470        480 
HREKVFEESA TGDGPIDACF RAIERALGIE SMVSTYSVRS ATAGREALGE ALVRISDGSV 

       490        500        510        520 
SFNGRGISTD IIEASARAYI QALGLRLEHF ENNTPETIDH GV

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References

[1]"Complete sequence of Prosthecochloris vibrioformis DSM 265."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Schuster S.C., Bryant D.A., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 265 EMBL ABP37186.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000607 Genomic DNA. Translation: ABP37186.1.
RefSeqYP_001130688.1. NC_009337.1.

3D structure databases

ProteinModelPortalA4SFC7.
ModBaseSearch...

Protein-protein interaction databases

STRING290318.Cvib_1174.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP37186; ABP37186; Cvib_1174.
GeneID4970860.
KEGGpvi:Cvib_1174.
PATRIC21396818. VBIChlPha132153_1239.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0119.
HOGENOMHOG000046859.
KOK01649.
OMAVWSVHCH.
ProtClustDBPRK00915.

Enzyme and pathway databases

BioCycCPHA290318:GHNQ-1224-MONOMER.
UniPathwayUPA00048; UER00070.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01025. LeuA_type1.
InterProIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view]
PfamPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMSSF110921. 2-isopropylmalate_synth_dimer. 1 hit.
TIGRFAMsTIGR00973. leuA_bact. 1 hit.
PROSITEPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4SFC7_PROVI
AccessionPrimary (citable) accession number: A4SFC7
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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