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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (Cvib_0811), Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciCPHA290318:G1G8E-1186-MONOMER
UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:Cvib_1123
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001971151 – 217N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST217

Interactioni

Protein-protein interaction databases

STRINGi290318.Cvib_1123

Structurei

3D structure databases

ProteinModelPortaliA4SF78
SMRiA4SF78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107ZQ0 Bacteria
COG0135 LUCA
HOGENOMiHOG000161598
KOiK01817
OMAiFYAKSPR
OrthoDBiPOG091H01PA

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

A4SF78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRTKICGIT RLNDALHASS EGVDALGFNF SRKSPRSITP SAAKKIIDEL
60 70 80 90 100
PPFVSKVGIF VEQSPAEIAD ICSYSKIAVA QLHSERYSAA DARFLKDMVH
110 120 130 140 150
VIRVFRPDGS FSPQSLTPFA EESGVRTFLF DAYKEGMEGG TGEEIETSVA
160 170 180 190 200
RQIFPAEGAP FFRVLAGGLN PGNVAEAIRQ FRPYGVDTAS GVEAKPGIKD
210
PEKISAFLLA VRLANQP
Length:217
Mass (Da):23,466
Last modified:May 15, 2007 - v1
Checksum:i1842C556AE71A31F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA Translation: ABP37137.1
RefSeqiWP_011890360.1, NC_009337.1

Genome annotation databases

EnsemblBacteriaiABP37137; ABP37137; Cvib_1123
KEGGipvi:Cvib_1123

Similar proteinsi

Entry informationi

Entry nameiTRPF_CHLPM
AccessioniPrimary (citable) accession number: A4SF78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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