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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei319Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCobalamin biosynthesis

Enzyme and pathway databases

BioCyciCPHA290318:G1G8E-866-MONOMER
UniPathwayiUPA00061; UER00516

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:Cvib_0822
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000006700 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000782441 – 354Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST354

Interactioni

Protein-protein interaction databases

STRINGi290318.Cvib_0822

Structurei

3D structure databases

ProteinModelPortaliA4SEC8
SMRiA4SEC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUP Bacteria
COG2038 LUCA
HOGENOMiHOG000263499
KOiK00768
OMAiATFGGFE
OrthoDBiPOG091H0031

Family and domain databases

CDDicd02439 DMB-PRT_CobT, 1 hit
Gene3Di1.10.1610.102 hits
HAMAPiMF_00230 CobT, 1 hit
InterProiView protein in InterPro
IPR003200 Nict_dMeBzImd_PRibTrfase-like
IPR023195 Nict_dMeBzImd_PRibTrfase_N
IPR017846 Nict_dMeBzImd_PRibTrfase_pro
IPR036087 Nict_dMeBzImd_PRibTrfase_sf
PfamiView protein in Pfam
PF02277 DBI_PRT, 1 hit
SUPFAMiSSF52733 SSF52733, 1 hit
TIGRFAMsiTIGR03160 cobT_DBIPRT, 1 hit

Sequencei

Sequence statusi: Complete.

A4SEC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKFLALIA AVSPADHSLS GAAQAHLDDL TKPQGSLGRL EEIALRFVQA
60 70 80 90 100
TASLSPVINR KKICCFAGDH GVAREGVSAF PSEVTPQMVY TMLSGGAAIN
110 120 130 140 150
VFARHVGADL AVVDMGVNHD FPDHPVLVKR KVAKGTGNIA AGPAMSENEA
160 170 180 190 200
IGAILAGAAL AAEAHDEGYH LLGTGEMGIA NTTPAAALYS VLLGVPVDGI
210 220 230 240 250
TGRGTGIDDE RLQHKKEVIK RAVGVNAGLC TTPLGTLAAL GGYEIAGIAG
260 270 280 290 300
FILGAAACRV PVVVDGFISS AGAVVAMKLC PVVADYLFFS HLSNEQGHRA
310 320 330 340 350
VMQALGARPI LDLDLRLGEG TGAALAMQMI EASVKMYNEM ATFSSASVSE

KDGE
Length:354
Mass (Da):36,438
Last modified:May 15, 2007 - v1
Checksum:i79C28ACBDA44B54E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA Translation: ABP36837.1
RefSeqiWP_011890062.1, NC_009337.1

Genome annotation databases

EnsemblBacteriaiABP36837; ABP36837; Cvib_0822
KEGGipvi:Cvib_0822

Similar proteinsi

Entry informationi

Entry nameiCOBT_CHLPM
AccessioniPrimary (citable) accession number: A4SEC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome