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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCPHA290318:G1G8E-631-MONOMER
UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Cvib_0597
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000006700 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000760131 – 341S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST341

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290318.Cvib_0597

Structurei

3D structure databases

ProteinModelPortaliA4SDR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N Bacteria
COG0809 LUCA
HOGENOMiHOG000004401
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

A4SDR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSDFDYSL PEERIAKYPP DNRGATRLLV LNRHTGSVQH ARYSNLEAFL
60 70 80 90 100
GYGDLLVINT TKVVRARLFA VKQTGAAIEL MLLEKHEGPQ NLALYRGRLK
110 120 130 140 150
KGDRLLAHGH ELIVEELAGQ GVARLSVEGI ESVHALFQNH AEVPIPPYLK
160 170 180 190 200
RDAEAVDRER YQTVFAEHPG SVAAPTASLN MTPELLLKLE KGGVATAVMT
210 220 230 240 250
LHVGLGTFLP IRTETMEEHV MHREFYSIPA RTIEQIHETR RSGGRVVALG
260 270 280 290 300
TTVTRALEHA ATRISAFSGS DPLVGEADIF IHPGYSFQTI DALLTNFHAP
310 320 330 340
RSTVLMLTAA FAGADHLRAA YREAVEKRYD FLSYGDSMLI S
Length:341
Mass (Da):37,703
Last modified:May 15, 2007 - v1
Checksum:i732D28F6791DE1D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA Translation: ABP36619.1
RefSeqiWP_011889847.1, NC_009337.1

Genome annotation databases

EnsemblBacteriaiABP36619; ABP36619; Cvib_0597
KEGGipvi:Cvib_0597

Similar proteinsi

Entry informationi

Entry nameiQUEA_CHLPM
AccessioniPrimary (citable) accession number: A4SDR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health