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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Cvib_0507

Organism
Prosthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Sitei256 – 2561Critical for catalysisUniRule annotation
Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
Sitei421 – 4211Critical for catalysisUniRule annotation
Binding sitei548 – 5481SubstrateUniRule annotation
Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCPHA290318:GHNQ-518-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Cvib_0507Imported
OrganismiProsthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))Imported
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000006700 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi290318.Cvib_0507.

Structurei

3D structure databases

ProteinModelPortaliA4SDH0.
SMRiA4SDH0. Positions 7-741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A4SDH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNATIIYT KIDEAPALAT YSLLPVIQAF VKGTGIGVET RDISLAGRII
60 70 80 90 100
ANFPENLTEE QKIPDYLAEL GELALKPEAN IIKLPNISAS IPQLQAAIKE
110 120 130 140 150
LQSQGYKIPD YPESPSTDAE KALQARFAKV LGSAVNPVLR EGNSDRRAPL
160 170 180 190 200
SVKKYAQNNP HRMAAWSADS KSSIASMASG DFYGSEKSVT IAAPTTVRIE
210 220 230 240 250
FVGAEGSVTV LKDKTSLLQD EVIDTAVMNV RSLRSFFEAQ IDAAKKNGTL
260 270 280 290 300
LSLHLKATMM KVSDPIMFGH AVSVFYRDVF EKHAAVIKEL GVNVRNGLGD
310 320 330 340 350
LYAKIQNLPD AQRSEIEADI QAVYPTRPAL AMVDSDKGIT NLHVPNDIIV
360 370 380 390 400
DASMPVVIRD GGKMWGPDGQ LHDTTAMIPD RCYATMYQAM VEDCKKNGAF
410 420 430 440 450
DPATIGTVPN VGLMAQKAEE YGSHDKTFTA PAEGFIRVVD AAGTVLMEQA
460 470 480 490 500
VETGDIFRMC QAKDAPIRDW VKLAVSRARA TGAPAIFWLD SSRAHDAQLI
510 520 530 540 550
EKVGTYLKEH DTAGLDIRIM NPVEAMQFSL GRLRAGQDTI SVTGNVLRDY
560 570 580 590 600
LTDLFPIIEL GTSAKMLSVV PLMNGGGLFE TGAGGSAPKH VQQFEKEGYL
610 620 630 640 650
RWDSLGEFSA LAASFEYLAS AFSNEKAAVL AETLDQAIGK FLDNRKSPAR
660 670 680 690 700
KVGQIDNRGS HFYLALYWAE ALAAQSGDGE LKSRFADVAA KLAAAETAIN
710 720 730 740
EELIAAQGKP VAMGGYYHVD EALVSAAMRP SATFNAIIDT L
Length:741
Mass (Da):80,016
Last modified:May 15, 2007 - v1
Checksum:i733144D98B33B164
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA. Translation: ABP36529.1.
RefSeqiWP_011889757.1. NC_009337.1.

Genome annotation databases

EnsemblBacteriaiABP36529; ABP36529; Cvib_0507.
KEGGipvi:Cvib_0507.
PATRICi21395366. VBIChlPha132153_0535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA. Translation: ABP36529.1.
RefSeqiWP_011889757.1. NC_009337.1.

3D structure databases

ProteinModelPortaliA4SDH0.
SMRiA4SDH0. Positions 7-741.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290318.Cvib_0507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP36529; ABP36529; Cvib_0507.
KEGGipvi:Cvib_0507.
PATRICi21395366. VBIChlPha132153_0535.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciCPHA290318:GHNQ-518-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Prosthecochloris vibrioformis DSM 265."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Schuster S.C., Bryant D.A., Richardson P.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 265Imported.

Entry informationi

Entry nameiA4SDH0_PROVI
AccessioniPrimary (citable) accession number: A4SDH0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: July 22, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.