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A4SDH0

- A4SDH0_PROVI

UniProt

A4SDH0 - A4SDH0_PROVI

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Cvib_0507

Organism
Prosthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Sitei256 – 2561Critical for catalysisUniRule annotation
Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
Sitei421 – 4211Critical for catalysisUniRule annotation
Binding sitei548 – 5481SubstrateUniRule annotation
Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCPHA290318:GHNQ-518-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Cvib_0507Imported
OrganismiProsthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))Imported
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000006700: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi290318.Cvib_0507.

Structurei

3D structure databases

ProteinModelPortaliA4SDH0.
SMRiA4SDH0. Positions 7-741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A4SDH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKNATIIYT KIDEAPALAT YSLLPVIQAF VKGTGIGVET RDISLAGRII
60 70 80 90 100
ANFPENLTEE QKIPDYLAEL GELALKPEAN IIKLPNISAS IPQLQAAIKE
110 120 130 140 150
LQSQGYKIPD YPESPSTDAE KALQARFAKV LGSAVNPVLR EGNSDRRAPL
160 170 180 190 200
SVKKYAQNNP HRMAAWSADS KSSIASMASG DFYGSEKSVT IAAPTTVRIE
210 220 230 240 250
FVGAEGSVTV LKDKTSLLQD EVIDTAVMNV RSLRSFFEAQ IDAAKKNGTL
260 270 280 290 300
LSLHLKATMM KVSDPIMFGH AVSVFYRDVF EKHAAVIKEL GVNVRNGLGD
310 320 330 340 350
LYAKIQNLPD AQRSEIEADI QAVYPTRPAL AMVDSDKGIT NLHVPNDIIV
360 370 380 390 400
DASMPVVIRD GGKMWGPDGQ LHDTTAMIPD RCYATMYQAM VEDCKKNGAF
410 420 430 440 450
DPATIGTVPN VGLMAQKAEE YGSHDKTFTA PAEGFIRVVD AAGTVLMEQA
460 470 480 490 500
VETGDIFRMC QAKDAPIRDW VKLAVSRARA TGAPAIFWLD SSRAHDAQLI
510 520 530 540 550
EKVGTYLKEH DTAGLDIRIM NPVEAMQFSL GRLRAGQDTI SVTGNVLRDY
560 570 580 590 600
LTDLFPIIEL GTSAKMLSVV PLMNGGGLFE TGAGGSAPKH VQQFEKEGYL
610 620 630 640 650
RWDSLGEFSA LAASFEYLAS AFSNEKAAVL AETLDQAIGK FLDNRKSPAR
660 670 680 690 700
KVGQIDNRGS HFYLALYWAE ALAAQSGDGE LKSRFADVAA KLAAAETAIN
710 720 730 740
EELIAAQGKP VAMGGYYHVD EALVSAAMRP SATFNAIIDT L
Length:741
Mass (Da):80,016
Last modified:May 15, 2007 - v1
Checksum:i733144D98B33B164
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA. Translation: ABP36529.1.
RefSeqiYP_001130031.1. NC_009337.1.

Genome annotation databases

EnsemblBacteriaiABP36529; ABP36529; Cvib_0507.
GeneIDi4971192.
KEGGipvi:Cvib_0507.
PATRICi21395366. VBIChlPha132153_0535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA. Translation: ABP36529.1 .
RefSeqi YP_001130031.1. NC_009337.1.

3D structure databases

ProteinModelPortali A4SDH0.
SMRi A4SDH0. Positions 7-741.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290318.Cvib_0507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP36529 ; ABP36529 ; Cvib_0507 .
GeneIDi 4971192.
KEGGi pvi:Cvib_0507.
PATRICi 21395366. VBIChlPha132153_0535.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci CPHA290318:GHNQ-518-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Prosthecochloris vibrioformis DSM 265."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Schuster S.C., Bryant D.A., Richardson P.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 265Imported.

Entry informationi

Entry nameiA4SDH0_PROVI
AccessioniPrimary (citable) accession number: A4SDH0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3