A4SCQ6 (EFG_PROVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	Cvib_0243

Organism

Prosthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265)) [Complete proteome] [HAMAP]

Taxonomic identifier

290318 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	704 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 704	704	Elongation factor G HAMAP MF_00054_B		PRO_1000074967
Regions
	Nucleotide binding	17 – 24	8	GTP By similarity
	Nucleotide binding	90 – 94	5	GTP By similarity
	Nucleotide binding	144 – 147	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4SCQ6 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 81923B68A0AA4C71	FASTA	704	78,045
	10 20 30 40 50 60 MTRQVALDKV RNIGIMAHID AGKTTTTERI LYYTGRLHRM GEVHDGGATM DWMEQEKERG 70 80 90 100 110 120 ITITSAATTC FWSPKYGNYK GENHRINIID TPGHVDFTVE VERSLRVLDG AVALFCAVGG 130 140 150 160 170 180 VEPQSETVWR QANKYGVPRI AYINKMDRTG ADFFDTIKAI RERLNSNPVP LQIPIGEGEI 190 200 210 220 230 240 YAGFVDLIRM KGIIFDKEDG STYEEVEIPH DLENEARTWR INMLEAVSEV DETLLEKYLN 250 260 270 280 290 300 GEDITESEVR KVLRQATLNV DIIPVLCGSS FKNKGVQFML DAVVDYLASP LDDGEVEGHH 310 320 330 340 350 360 PRTEEDVVRH PSDDEPFAAL AFKIATDPFV GKLTFFRVYS GMLKAGSYVL NSITGKKERV 370 380 390 400 410 420 GRVLQMHSNK REDLDAVYAG DIAAAVGLKE VRTGDTLCDE ASPVVLEKMV FPEPVIQIAI 430 440 450 460 470 480 EPKTKVDSDK LGVSLAKLAE EDPTFRVKTD DETGQTLIAG MGELHLEILV DRLRREFKVE 490 500 510 520 530 540 ANVGQPQVAY RETIRSKVDF EGKFVRQSGG KGQFGLVNIT VEPLEEGKGY EFVDAVKGGV 550 560 570 580 590 600 IPREYIPAVN AGIQEAMKDG VVAGYPMQDI KVTLFDGKYH DVDSSEMAFK IAGSIGFKGG 610 620 630 640 650 660 ARKANPVLLE PIMKVEVVTP EEYLGDVMGD LSGRRGHIEG MGQRAGAQFV GAKVPLSAMF 670 680 690 700 GYSTDLRSMT QGRANYSMEF ESYREVPKNI AETLQEKRSS KDAQ

References

[1]

"Complete sequence of Prosthecochloris vibrioformis DSM 265." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Schuster S.C., Bryant D.A., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 265.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000607 Genomic DNA. Translation: ABP36265.1.
RefSeq	YP_001129767.1. NC_009337.1.
3D structure databases
ProteinModelPortal	A4SCQ6.
SMR	A4SCQ6. Positions 5-694.
ModBase	Search...
Protein-protein interaction databases
STRING	A4SCQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4970250.
GenomeReviews	Gene locus Cvib_0243 in contig CP000607_GR.
KEGG	pvi:Cvib_0243.
PATRIC	21394820. VBIChlPha132153_0265.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0480.
HOGENOM	HBG737692.
OMA	CNEWREK.
PhylomeDB	A4SCQ6.
ProtClustDB	PRK00007.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_PROVI

Accession

Primary (citable) accession number: A4SCQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program