SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4SCK8

- GCSPB_PROVI

UniProt

A4SCK8 - GCSPB_PROVI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, Cvib_0194
Organism
Prosthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPHA290318:GHNQ-201-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:Cvib_0194
OrganismiProsthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000006700: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000083231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi290318.Cvib_0194.

Structurei

3D structure databases

ProteinModelPortaliA4SCK8.
SMRiA4SCK8. Positions 2-482.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A4SCK8-1 [UniParc]FASTAAdd to Basket

« Hide

MNEPLISDIS RTGRKGYSLN SSDLIRTPHS QLIPGKFLRQ SPAELPEVPE    50
SEVVRHFLRL STLNYHVDKD MYPLGSCTMK YNPKINDETC SLEGFAALHP 100
MQPESTVQGA LQLMHELSGM LAEITGMASV TLQPAAGAHG ELAGILLIKK 150
YHEAQHSKRT TLLVVDSAHG TNPASAALAG YTIVSVKSNG IGRTDLNDLK 200
EKLNGDVAAL MLTNPNTIGL FEKEIVAIAD MVHKNGSLLY MDGANMNALL 250
GITRPGDMGF DVVHLNLHKT FSAPHGGGGP GSGPVGVCEK LIPHLPVPVI 300
EKRATSEGAR YHLTGDCPDS IGRMMNFHGN FAVLIRAYTY IRMLGAEGLR 350
RVSENAIINA NYLLSRLDGA YSLPYPKPVL HEFCLSGDLQ KKSHGVRTLD 400
IAKRLLDYGF HAPTIYFPLI VSEALMIEPT ETESRETLDR FADAMLQIAK 450
EAEECPETVL AAPETTPVRR LDEAMASRQL NICCR 485
Length:485
Mass (Da):52,899
Last modified:May 15, 2007 - v1
Checksum:iC921EF048A17C3BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000607 Genomic DNA. Translation: ABP36217.1.
RefSeqiWP_011889446.1. NC_009337.1.
YP_001129719.1. NC_009337.1.

Genome annotation databases

EnsemblBacteriaiABP36217; ABP36217; Cvib_0194.
GeneIDi4971008.
KEGGipvi:Cvib_0194.
PATRICi21394712. VBIChlPha132153_0212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000607 Genomic DNA. Translation: ABP36217.1 .
RefSeqi WP_011889446.1. NC_009337.1.
YP_001129719.1. NC_009337.1.

3D structure databases

ProteinModelPortali A4SCK8.
SMRi A4SCK8. Positions 2-482.
ModBasei Search...

Protein-protein interaction databases

STRINGi 290318.Cvib_0194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP36217 ; ABP36217 ; Cvib_0194 .
GeneIDi 4971008.
KEGGi pvi:Cvib_0194.
PATRICi 21394712. VBIChlPha132153_0212.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CPHA290318:GHNQ-201-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Prosthecochloris vibrioformis DSM 265."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Schuster S.C., Bryant D.A., Richardson P.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 265.

Entry informationi

Entry nameiGCSPB_PROVI
AccessioniPrimary (citable) accession number: A4SCK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi