Skip Header

Contribute Send feedback
Read comments (?) or add your own

A4SCI6 (A4SCI6_PROVI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length827 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1201O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
A4SCI6 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 23D7FFA697068B05

FASTA82792,472
        10         20         30         40         50         60 
MQRQRILPVT IEEEMRGSYL DYSMSVIVSR ALPDVRDGLK PVHRRVLYGM HELGLQAGKP 

        70         80         90        100        110        120 
HKKSARVVGE VLGKFHPHGD SAVYDSLVRM VQDFSLRYPL IDGQGNFGSV DGDSPAAMRY 

       130        140        150        160        170        180 
TEVRMKAIAG EMLKDLDKET VEYSLNFDDS LEEPTVLPSS IPNLLVNGAS GIAVGMATNI 

       190        200        210        220        230        240 
PPQNLREVVD GMTALIDNPD IEIEELMKHV IAPDFPTGGI IYGYEGVRLA YTTGRGKVVI 

       250        260        270        280        290        300 
RARALVEVTQ KNGRESIVVT ELPYQVNKVR LIEKIVELVH DKKVEGIADI RDESDRDGMR 

       310        320        330        340        350        360 
LVIELKRDAV AKVVLNNLYK HTPMQDTFGV IMLALVDGVP RVLNLKEMMQ FYIQHRNEIV 

       370        380        390        400        410        420 
LRRTRYDLTA AEKRAHILEG LKICLDNLDE VITTIRESPD ANTAQARLIE RFGLSELQSK 

       430        440        450        460        470        480 
AILEMRLQRL TGMERKKIDL EYAETIALIE ELRDILASPE RQMQIIRTEL LKVREVYGDE 

       490        500        510        520        530        540 
RRTEIVPQEG DFSIEDMIAQ EDVVITITHD GFIKRFPVSG YRRQARGGKG VTGAQAKNDD 

       550        560        570        580        590        600 
FIEHMFVAST HNYILFFTSN GRCYWLKVYE IPEAGRAARG RSLANIMELN PGETIKTYIN 

       610        620        630        640        650        660 
IRNFDEPGFI MMATADGIVK KTALEEFSRP RRNGIAAITI DTGDALLDAR LTDGDHQVIL 

       670        680        690        700        710        720 
AKSSGLVVRF PESQVRPMGR TAMGVKGITL DRGEKCISMV TTKRLDTALL AVTDNGFGKR 

       730        740        750        760        770        780 
SKVEDYRLTK RGARGVITLK AHEKIGALVG LLDVNDDDDL IIITSHGIVN RQHVSDIRIT 

       790        800        810        820 
GRNTSGVRLV RLMEGDAVSA LARVPKTDED TDTETLLEDP DGQLPLL

« Hide

References

[1]"Complete sequence of Prosthecochloris vibrioformis DSM 265."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Schuster S.C., Bryant D.A., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 265 EMBL ABP36195.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000607 Genomic DNA. Translation: ABP36195.1.
RefSeqYP_001129697.1. NC_009337.1.

3D structure databases

ProteinModelPortalA4SCI6.
SMRA4SCI6. Positions 28-485.
ModBaseSearch...

Protein-protein interaction databases

STRING290318.Cvib_0172.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP36195; ABP36195; Cvib_0172.
GeneID4971271.
KEGGpvi:Cvib_0172.
PATRIC21394656. VBIChlPha132153_0189.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycCPHA290318:GHNQ-223-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4SCI6_PROVI
AccessionPrimary (citable) accession number: A4SCI6
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info