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Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene

dxr

Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: isopentenyl diphosphate biosynthesis via DXP pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr)
  2. 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD)
  3. 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE)
  4. 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF)
  5. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG)
  6. 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH)
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via DXP pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate, the pathway isopentenyl diphosphate biosynthesis via DXP pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124SubstrateUniRule annotation1
Metal bindingi149Divalent metal cationUniRule annotation1
Metal bindingi151Divalent metal cationUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei175SubstrateUniRule annotation1
Binding sitei198SubstrateUniRule annotation1
Metal bindingi220Divalent metal cationUniRule annotation1
Binding sitei220SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 36NADPUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIsoprene biosynthesis
LigandMetal-binding, NADP

Enzyme and pathway databases

BioCyciCPHA290318:G1G8E-142-MONOMER
UniPathwayiUPA00056; UER00092

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation (EC:1.1.1.267UniRule annotation)
Short name:
DXP reductoisomeraseUniRule annotation
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomeraseUniRule annotation
2-C-methyl-D-erythritol 4-phosphate synthaseUniRule annotation
Gene namesi
Name:dxrUniRule annotation
Ordered Locus Names:Cvib_0138
OrganismiChlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Taxonomic identifieri290318 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000006700 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000773401 – 3841-deoxy-D-xylulose 5-phosphate reductoisomeraseAdd BLAST384

Interactioni

Protein-protein interaction databases

STRINGi290318.Cvib_0138

Structurei

3D structure databases

ProteinModelPortaliA4SCF3
SMRiA4SCF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEA Bacteria
COG0743 LUCA
HOGENOMiHOG000007220
KOiK00099
OMAiDSEHFGL
OrthoDBiPOG091H0052

Family and domain databases

HAMAPiMF_00183 DXP_reductoisom, 1 hit
InterProiView protein in InterPro
IPR003821 DXP_reductoisomerase
IPR013644 DXP_reductoisomerase_C
IPR013512 DXP_reductoisomerase_N
IPR026877 DXPR_C
IPR036169 DXPR_C_sf
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR30525 PTHR30525, 1 hit
PfamiView protein in Pfam
PF08436 DXP_redisom_C, 1 hit
PF02670 DXP_reductoisom, 1 hit
PF13288 DXPR_C, 1 hit
PIRSFiPIRSF006205 Dxp_reductismrs, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF69055 SSF69055, 1 hit
TIGRFAMsiTIGR00243 Dxr, 1 hit

Sequencei

Sequence statusi: Complete.

A4SCF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALSILGST GSIGLSTLDV VRRHKESFSV VGLAEGHDVH ALAEQIKEFR
60 70 80 90 100
PTIVSVRDEN AADELKTLLG PADRPEIVHG IEGAGTVAAA EGSDMVVSAI
110 120 130 140 150
VGAAGLTPTI KAIKAGKDIA LANKETLVVA GQLVSDLVKQ NGVELLPVDS
160 170 180 190 200
EHSAIFQSLL GHRAEDVERI ILTASGGPFR NTPLEEMKKA GPEQALKHPQ
210 220 230 240 250
WTMGAKITID SATMMNKGLE VIEAHWLFNM PADRIGVVVH PQSIVHSMVE
260 270 280 290 300
YRDGCVIAQL GSPDMRAPIA YALSYPERSE SGVKKLNLAE IGTLTFEEPD
310 320 330 340 350
MVRFPALQLA FDALKAGKTY PAVLNAANEI AVAAFLNKQI GFTDIADTVD
360 370 380
KTMQAHEAYT PMELDEYIHA DRWARQTAST FISS
Length:384
Mass (Da):41,277
Last modified:May 15, 2007 - v1
Checksum:i6B31841C70A22F36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000607 Genomic DNA Translation: ABP36162.1
RefSeqiWP_011889391.1, NC_009337.1

Genome annotation databases

EnsemblBacteriaiABP36162; ABP36162; Cvib_0138
KEGGipvi:Cvib_0138

Similar proteinsi

Entry informationi

Entry nameiDXR_CHLPM
AccessioniPrimary (citable) accession number: A4SCF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health