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A4S0Q3 (A4S0Q3_OSTLU) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
ORF Names:OSTLU_32825 EMBL ABO97072.1
OrganismOstreococcus lucimarinus (strain CCE9901) [Complete proteome]
Taxonomic identifier436017 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Chlorophyta › Mamiellophyceae › Mamiellales › Ostreococcus

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding23 – 286NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding46 – 483NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding91 – 933NADP By similarity PIRSR PIRSR000109-3
Region145 – 1473Substrate binding By similarity PIRSR PIRSR000109-2
Region202 – 2032Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1991Proton acceptor By similarity PIRSR PIRSR000109-1
Active site2061Proton donor By similarity PIRSR PIRSR000109-1
Binding site1191NADP By similarity PIRSR PIRSR000109-3
Binding site1191Substrate By similarity PIRSR PIRSR000109-2
Binding site2071Substrate By similarity PIRSR PIRSR000109-2
Binding site2801Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site3071Substrate By similarity PIRSR PIRSR000109-2
Binding site4701Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4761Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A4S0Q3 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: D316EB00E8E01D88

FASTA50754,667
        10         20         30         40         50         60 
MTATARATAA NGAGEKSRIG LCGLAVMGQN LALNVAEKGF DISVYNRSSD KTDVCVERAK 

        70         80         90        100        110        120 
KEGLGAKLRG YHEMKDFVAS LAKPRCVIIL VKAGAPVDAT IAGLSQFLEP GDCIIDGGNE 

       130        140        150        160        170        180 
WYENTERRSK EAAEKGLLYV GMGVSGGEEG ARNGPSMMPG GSKEAYDIIA DILKPVSAQT 

       190        200        210        220        230        240 
DSGACVTYVG PGGAGNFVKM VHNGIEYGDM QLISEAYDVL KTVGGLTNDE LAAAFTEWNE 

       250        260        270        280        290        300 
AELESYLIEI SSIILAKKDD QSGKSDDFLV DKILDKTGMK GTGKWTVQQA AELSIAAPTI 

       310        320        330        340        350        360 
ASSLDARCLS GLKDERVNAE AFYAKLGLAP AGAMGPADKK QLINDVRYAL YASKVTSYAQ 

       370        380        390        400        410        420 
GMNLIRAKSN EQGWNLNLGE MARIWKGGCI IRAGFLDRIK NAYDRDSKLP SLLVDEQFAK 

       430        440        450        460        470        480 
EMIEREASWR RVVTAAINAG VSVPSMSGSL AYFDTYRRAR SPANLVQAQR DFFGSHTYER 

       490        500 
TDMEGWYHTL WSDMNSADSI TTSGYKA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000587 Genomic DNA. Translation: ABO97072.1.
RefSeqXP_001418779.1. XM_001418742.1.

3D structure databases

ProteinModelPortalA4S0Q3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4S0Q3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5002807.
KEGGolu:OSTLU_32825.

Phylogenomic databases

HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBA4S0Q3.
ProtClustDBPLN02350.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4S0Q3_OSTLU
AccessionPrimary (citable) accession number: A4S0Q3
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info