A4RTX6 (A4RTX6_OSTLU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Serine hydroxymethyltransferase RuleBase RU000585
EC=2.1.2.1 RuleBase RU000585

Gene names

ORF Names:

OSTLU_30421 EMBL ABO95154.1

Organism

Ostreococcus lucimarinus (strain CCE9901) [Complete proteome]

Taxonomic identifier

436017 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Chlorophyta › Mamiellophyceae › Mamiellales › Ostreococcus

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Interconversion of serine and glycine By similarity. RuleBase RU000585
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. RuleBase RU000585
Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000585
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU000585
Sequence similarities	Belongs to the SHMT family. RuleBase RU004104

Ontologies

Keywords
Biological process	One-carbon metabolism RuleBase RU000585
Ligand	Pyridoxal phosphate RuleBase RU000585
Molecular function	Transferase RuleBase RU000585
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4RTX6 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: C1C3E04E70174246	FASTA	464	51,249
	10 20 30 40 50 60 MNRVFPEALA PLKSADKEMY DLIQLEKRRQ IGGIELIASE NFTSAPVMEA LGSALTNKYS 70 80 90 100 110 120 EGLPGARYYG GNEVIDRVET LCQRRALAAY RLDEKEWGVN VQPYSGSPAN MAVYTALLNP 130 140 150 160 170 180 HDRIMGLDLP SGGHLTHGYY NSNGKKISAT SIFFESLPYK VDPKTGYIDY DKLEEKAMDF 190 200 210 220 230 240 RPKMIVCGGS AYARDWDYAR FREIADKCGA MLMMDMAHIS GLVAAEEQAQ PFEYCDIVTT 250 260 270 280 290 300 TTHKSLRGPR SGMIFFRRGV NAKTGKDYNY ESRINMAVFP ALQGGPHNHQ IGALAVALKY 310 320 330 340 350 360 AQTPEFKTYI KQVKANARAL GETLVSKGYN LVTGGTDNHL VLWDLRPLGL TGSKMEYLCD 370 380 390 400 410 420 LLHITLNKNA VFGDASALSP GGVRIGAPAM TSRGLVESDF VQIAEFLSRA ADLCLEVQKS 430 440 450 460 HGKMLKDWKK GLDNNPKVAA MRDEVEAFAS AFEMPAFTKE SIDI

References

[1]

"The tiny eukaryote Ostreococcus provides genomic insights into the paradox of plankton speciation." Palenik B., Grimwood J., Aerts A., Rouze P., Salamov A., Putnam N., Dupont C., Jorgensen R., Derelle E., Rombauts S., Zhou K., Otillar R., Merchant S.S., Podell S., Gaasterland T., Napoli C., Gendler K., Manuell A. , Tai V., Vallon O., Piganeau G., Jancek S., Heijde M., Jabbari K., Bowler C., Lohr M., Robbens S., Werner G., Dubchak I., Pazour G.J., Ren Q., Paulsen I., Delwiche C., Schmutz J., Rokhsar D., Van de Peer Y., Moreau H., Grigoriev I.V. Proc. Natl. Acad. Sci. U.S.A. 104:7705-7710(2007) [PubMed: 17460045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000583 Genomic DNA. Translation: ABO95154.1.
RefSeq	XP_001416861.1. XM_001416824.1.
3D structure databases
ProteinModelPortal	A4RTX6.
SMR	A4RTX6. Positions 11-457.
ModBase	Search...
Protein-protein interaction databases
STRING	A4RTX6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5000954.
KEGG	olu:OSTLU_30421.
Phylogenomic databases
HOGENOM	HBG301263.
OMA	LKEVASP.
PhylomeDB	A4RTX6.
ProtClustDB	PLN03226.
Family and domain databases
HAMAP	MF_00051. SHMT. [Tree]
InterPro	IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. IPR019775. WD40_repeat_CS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00600.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. PS00678. WD_REPEATS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4RTX6_OSTLU

Accession

Primary (citable) accession number: A4RTX6

Entry history

Integrated into UniProtKB/TrEMBL:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)