A4RQ11 (AMPP2_MAGO7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase MGG_05684
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

MGG_05684

Organism

Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome]

Taxonomic identifier

242507 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Magnaporthales › Magnaporthaceae › Magnaporthe › Magnaporthe oryzae

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Probable Xaa-Pro aminopeptidase MGG_05684		PRO_0000411836
Sites
	Metal binding	285	1	Manganese 2 By similarity
	Metal binding	296	1	Manganese 1 By similarity
	Metal binding	296	1	Manganese 2 By similarity
	Metal binding	447	1	Manganese 1 By similarity
	Metal binding	488	1	Manganese 1 By similarity
	Metal binding	488	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4RQ11 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 829B0ECC1E2D0B46	FASTA	526	58,488
	10 20 30 40 50 60 MGVEHELVVV DEFDALSIEL KRPNGSSSSS PSRAVSVEKY PAKTHARKVA DKLGVDKGLI 70 80 90 100 110 120 YLQGKPTTTY EDSDMEPPFR QRRYFYYMSG ADFPNAHLTY DVATDQLLLW IPTRQPREEL 130 140 150 160 170 180 YLGRIPSRED CMSRLDVDDC RDVVQMTRFI AAHLKHHPGT TLFLLHSDQA PGLDDLPVQY 190 200 210 220 230 240 AGRRLDIGRL RLAVDAARVI KTPFEIRQIR RANQVSSEAH RAVLRQIRHL RTEADVEAVF 250 260 270 280 290 300 VAACRVRGAR SQAYNPIAGA GANAATLHYV DNAAPLKGKQ TLVLDAGCEW DCYASDITRT 310 320 330 340 350 360 MPAAGRKFSP EAQTIYRIVE KMQNACIDLV RPGVSYLFIQ ATAQLVAIEE FLKIGLLVGD 370 380 390 400 410 420 KAKIAASRVV SAFFPHGLGH HVGLETHDVR SERLLGYDKS SAALWRGKRL VMSVEQCDRV 430 440 450 460 470 480 AELMVTARQQ GADARDALAE GMVITIEPGI YFNRQYIEAF CSDVPERGSF INKSVLDRYY 490 500 510 520 PVGGVRIEDD ILVTADGYEN LTTAPKGEEA LRIINGDDVE ADAVLV

References

[1]

"The genome sequence of the rice blast fungus Magnaporthe grisea." Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., Soanes D.M. , Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W. Nature 434:980-986(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CM001231 Genomic DNA. Translation: EHA57971.1.
RefSeq	XP_003710583.1. XM_003710535.1.
3D structure databases
ProteinModelPortal	A4RQ11.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	MGG_05684T0; MGG_05684T0; MGG_05684.
GeneID	2675942.
KEGG	mgr:MGG_05684.
Phylogenomic databases
KO	K14213.
OrthoDB	EOG4897VR.
Family and domain databases
Gene3D	3.90.230.10. 2 hits.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_MAGO7

Accession

Primary (citable) accession number: A4RQ11
Secondary accession number(s): G4MP22

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	May 15, 2007
Last modified:	March 6, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program