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A4RPY8

- CBPYA_MAGO7

UniProt

A4RPY8 - CBPYA_MAGO7

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei274 – 2741PROSITE-ProRule annotation
    Active sitei466 – 4661PROSITE-ProRule annotation
    Active sitei527 – 5271PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. mycelium development Source: PAMGO_MGG
    2. phytochelatin biosynthetic process Source: EnsemblFungi

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:MGG_05663
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 1

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. fungal-type vacuole Source: EnsemblFungi

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 133115By similarityPRO_0000407453Add
    BLAST
    Chaini134 – 552419Carboxypeptidase Y homolog APRO_0000407454Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi187 ↔ 427By similarity
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi321 ↔ 335By similarity
    Disulfide bondi345 ↔ 368By similarity
    Disulfide bondi352 ↔ 361By similarity
    Disulfide bondi390 ↔ 397By similarity
    Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi148305.A4RPY8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    KOiK13289.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4RPY8-1 [UniParc]FASTAAdd to Basket

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    MRIATSTLLV GAASAAFAPQ DGTQRVLNGF DSIKSAAHSI QKPLQTFEEA    50
    MASMTSEAKA NWDHLKLLVP DAEEQAKTFF PKKPKPASRK PDSAWDHIVK 100
    GADIQAMWVE GATPEETHRK IDGKLDNYNL RARSVDPSKL GVDTVKQYSG 150
    YLDDEANDKH LFYWFFESRN DPKNDPVVLW LNGGPGCSSL TGLLFELGPG 200
    AINAKIEIVH NPYAWNNNAS VIFLDQPVNV GYSYSGGSVS NTVAAGKDIY 250
    ALLTLFFHQF PEYAKQDFHI AGESYAGHYI PVFASEILSH KKRNINLKSV 300
    LIGNGLTDGL TQYEYYRPMA CGEGGWKAVL SESECQAMDN ALPRCQSMIQ 350
    NCYDSGSVWS CVPASIYCNN AMIGPYQRTG RNVYDIRGPC KDSGNLCYPE 400
    LGYISEYLNR REVMEALGAE VSSYDSCNFD INRNFLFQGD WMQPYHRLVP 450
    ELLNQIPVLI YAGDADFICN WLGNQGWTEA LEWKGKKDYN RADYSPLTLA 500
    SAHDVKPYGK VKSSGNFTFM KIFEAGHMVP YDQAEPSVDF VNRWLAGEWF 550
    AA 552
    Length:552
    Mass (Da):61,593
    Last modified:May 15, 2007 - v1
    Checksum:iB0F1815B4BD601B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001231 Genomic DNA. Translation: EHA57949.1.
    RefSeqiXP_003710561.1. XM_003710513.1.

    Genome annotation databases

    EnsemblFungiiMGG_05663T0; MGG_05663T0; MGG_05663.
    GeneIDi2676004.
    KEGGimgr:MGG_05663.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001231 Genomic DNA. Translation: EHA57949.1 .
    RefSeqi XP_003710561.1. XM_003710513.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 148305.A4RPY8.

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_05663T0 ; MGG_05663T0 ; MGG_05663 .
    GeneIDi 2676004.
    KEGGi mgr:MGG_05663.

    Phylogenomic databases

    eggNOGi COG2939.
    KOi K13289.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

    Entry informationi

    Entry nameiCBPYA_MAGO7
    AccessioniPrimary (citable) accession number: A4RPY8
    Secondary accession number(s): G4MP00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3