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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei274 – 2741PROSITE-ProRule annotation
Active sitei466 – 4661PROSITE-ProRule annotation
Active sitei527 – 5271PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: EnsemblFungi

GO - Biological processi

  1. mycelium development Source: PAMGO_MGG
  2. phytochelatin biosynthetic process Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:MGG_05663
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:MGG_05663.

Subcellular locationi

  1. Vacuole By similarity

GO - Cellular componenti

  1. fungal-type vacuole Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 133115By similarityPRO_0000407453Add
BLAST
Chaini134 – 552419Carboxypeptidase Y homolog APRO_0000407454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi187 ↔ 427By similarity
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi321 ↔ 335By similarity
Disulfide bondi345 ↔ 368By similarity
Disulfide bondi352 ↔ 361By similarity
Disulfide bondi390 ↔ 397By similarity
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi148305.A4RPY8.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiA4RPY8.
KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4RPY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIATSTLLV GAASAAFAPQ DGTQRVLNGF DSIKSAAHSI QKPLQTFEEA
60 70 80 90 100
MASMTSEAKA NWDHLKLLVP DAEEQAKTFF PKKPKPASRK PDSAWDHIVK
110 120 130 140 150
GADIQAMWVE GATPEETHRK IDGKLDNYNL RARSVDPSKL GVDTVKQYSG
160 170 180 190 200
YLDDEANDKH LFYWFFESRN DPKNDPVVLW LNGGPGCSSL TGLLFELGPG
210 220 230 240 250
AINAKIEIVH NPYAWNNNAS VIFLDQPVNV GYSYSGGSVS NTVAAGKDIY
260 270 280 290 300
ALLTLFFHQF PEYAKQDFHI AGESYAGHYI PVFASEILSH KKRNINLKSV
310 320 330 340 350
LIGNGLTDGL TQYEYYRPMA CGEGGWKAVL SESECQAMDN ALPRCQSMIQ
360 370 380 390 400
NCYDSGSVWS CVPASIYCNN AMIGPYQRTG RNVYDIRGPC KDSGNLCYPE
410 420 430 440 450
LGYISEYLNR REVMEALGAE VSSYDSCNFD INRNFLFQGD WMQPYHRLVP
460 470 480 490 500
ELLNQIPVLI YAGDADFICN WLGNQGWTEA LEWKGKKDYN RADYSPLTLA
510 520 530 540 550
SAHDVKPYGK VKSSGNFTFM KIFEAGHMVP YDQAEPSVDF VNRWLAGEWF

AA
Length:552
Mass (Da):61,593
Last modified:May 15, 2007 - v1
Checksum:iB0F1815B4BD601B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001231 Genomic DNA. Translation: EHA57949.1.
RefSeqiXP_003710561.1. XM_003710513.1.

Genome annotation databases

EnsemblFungiiMGG_05663T0; MGG_05663T0; MGG_05663.
GeneIDi2676004.
KEGGimgr:MGG_05663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001231 Genomic DNA. Translation: EHA57949.1.
RefSeqiXP_003710561.1. XM_003710513.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi148305.A4RPY8.

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiMGG_05663T0; MGG_05663T0; MGG_05663.
GeneIDi2676004.
KEGGimgr:MGG_05663.

Organism-specific databases

EuPathDBiFungiDB:MGG_05663.

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiA4RPY8.
KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiCBPYA_MAGO7
AccessioniPrimary (citable) accession number: A4RPY8
Secondary accession number(s): G4MP00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 15, 2007
Last modified: April 29, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.