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Protein

Signal peptidase complex catalytic subunit SEC11

Gene

SEC11

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.010

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11 (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I
Gene namesi
Name:SEC11
ORF Names:MGG_00113
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
Proteomesi
  • UP000009058 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:MGG_17533

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 130LumenalSequence analysisAdd BLAST95
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 172CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004123361 – 172Signal peptidase complex catalytic subunit SEC11Add BLAST172

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC).By similarity

Protein-protein interaction databases

STRINGi318829.MGG_17533T0

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiA4RGA1
KOiK13280
OrthoDBiEOG092C4ZUJ

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
PANTHERiPTHR10806 PTHR10806, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit

Sequencei

Sequence statusi: Complete.

A4RGA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSLGNPRQ AATQLLNFAL ILSTAFMMWK GLSVATDSPS PIVVVLSGSM
60 70 80 90 100
EPAFQRGDLL FLWNRNIVQE TDVGEIVVYN VKGKDIPIVH RIVRKFGAGP
110 120 130 140 150
KAKLLTKGDN NAADDTELYA KDQDYLERKD IIGSVVAYIP FVGYVTIMLS
160 170
EHPWMKTAML GIMGLMVVLQ RE
Length:172
Mass (Da):19,043
Last modified:May 15, 2007 - v1
Checksum:iF923B96D007572EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA Translation: EHA49440.1
RefSeqiXP_003719024.1, XM_003718976.1

Genome annotation databases

EnsemblFungiiMGG_17533T0; MGG_17533T0; MGG_17533
GeneIDi12985126
KEGGimgr:MGG_17533

Similar proteinsi

Entry informationi

Entry nameiSEC11_MAGO7
AccessioniPrimary (citable) accession number: A4RGA1
Secondary accession number(s): G4NEG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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