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Protein

Signal peptidase complex catalytic subunit SEC11

Gene

SEC11

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11 (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I
Gene namesi
Name:SEC11
ORF Names:MGG_00113
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
Proteomesi
  • UP000009058 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:MGG_17533.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 130LumenalSequence analysisAdd BLAST95
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 172CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004123361 – 172Signal peptidase complex catalytic subunit SEC11Add BLAST172

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC).By similarity

Structurei

3D structure databases

ProteinModelPortaliA4RGA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiA4RGA1.
KOiK13280.
OrthoDBiEOG092C4ZUJ.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4RGA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSLGNPRQ AATQLLNFAL ILSTAFMMWK GLSVATDSPS PIVVVLSGSM
60 70 80 90 100
EPAFQRGDLL FLWNRNIVQE TDVGEIVVYN VKGKDIPIVH RIVRKFGAGP
110 120 130 140 150
KAKLLTKGDN NAADDTELYA KDQDYLERKD IIGSVVAYIP FVGYVTIMLS
160 170
EHPWMKTAML GIMGLMVVLQ RE
Length:172
Mass (Da):19,043
Last modified:May 15, 2007 - v1
Checksum:iF923B96D007572EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA. Translation: EHA49440.1.
RefSeqiXP_003719024.1. XM_003718976.1.

Genome annotation databases

EnsemblFungiiMGG_17533T0; MGG_17533T0; MGG_17533.
GeneIDi12985126.
KEGGimgr:MGG_17533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA. Translation: EHA49440.1.
RefSeqiXP_003719024.1. XM_003718976.1.

3D structure databases

ProteinModelPortaliA4RGA1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS26.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiMGG_17533T0; MGG_17533T0; MGG_17533.
GeneIDi12985126.
KEGGimgr:MGG_17533.

Organism-specific databases

EuPathDBiFungiDB:MGG_17533.

Phylogenomic databases

InParanoidiA4RGA1.
KOiK13280.
OrthoDBiEOG092C4ZUJ.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC11_MAGO7
AccessioniPrimary (citable) accession number: A4RGA1
Secondary accession number(s): G4NEG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.