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A4RF25

- PMIP_MAGO7

UniProt

A4RF25 - PMIP_MAGO7

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Protein
Mitochondrial intermediate peptidase
Gene
OCT1, MGG_00487
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi587 – 5871Zinc; catalytic By similarity
Active sitei588 – 5881 By similarity
Metal bindingi591 – 5911Zinc; catalytic By similarity
Metal bindingi594 – 5941Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:MGG_00487
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 5

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535Mitochondrion Reviewed prediction
    Add
    BLAST
    Chaini36 – 812777Mitochondrial intermediate peptidase
    PRO_0000338587Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi148305.A4RF25.

    Structurei

    3D structure databases

    ProteinModelPortaliA4RF25.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi296 – 2994Poly-Ala

    Sequence similaritiesi

    Belongs to the peptidase M3 family.

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4RF25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKLLRPRPW VCNSCLNRVA FPKPYPVGSR STRWLSTAQS AAPAVSIPPV    50
    NPVPADHTTS GTHDDALLGK IFDCSSAWRD FSARSAKFPT ENAGLFRNAY 100
    LTSPDGFLTF AQSSLSKASA IVNRVLGAST IEEYKTIVRD LDRLSDLLCR 150
    VIDLSDFVRV THPDVRIQRA ASEAWYMVYQ YMNQLNTMTG LNDQLGKAME 200
    NSDVTKTWSE EEMAVAQLLK LDFMKSAVNL PQAARDRFVD LSQRISEIGS 250
    DFVNEMAPEQ RRVVLPSSKF QGMDPQIARR FTKHGYMQLP TMSGEAAAAL 300
    RTVHDEETRK AVYLAIRTAS SRSVGLLEAL LKHRAELADL AGFESYGHMT 350
    LRDRMMAKTP ESINKFLVEL SKNNAPRVLQ EVDSLLQEKK TLLASPSATL 400
    NPWDREYYIQ RIRNAQGKNV KHDNFFASYF SVGRVMQGLS RLFTRLYGIR 450
    FVPRETLPGE KWHPDVRRLD VVSDTDGHVA VLYCDLFYRE DKSPNPAHFT 500
    IRCSRAISED EISEAAVSTS EGGPAFGSPE SAANDGMAAS RGASGGPLKQ 550
    LPTIALVCDF PQRDNPLSGS KSKPASLTFA SLETLFHEMG HAIHSVLART 600
    SFQNVAGTRC ATDLAELPST LMEYFASDPS VLSLFARHAE TDEPLDYDLL 650
    AERVRSRGRF EGCDTDYQII LAMLDQAYHS PLASSESFDT TRAYHDLQRE 700
    HSPLGPDPSS TRWQGFFGHL FGYGSTYYSY LFDQVLAERA WKKVFSSGQD 750
    GAALSREAGE HLKESLLKWG GSREPWRCVS DVLRDERIAG GGEEAMALVG 800
    SWGTSNKSTM KH 812
    Length:812
    Mass (Da):90,362
    Last modified:May 15, 2007 - v1
    Checksum:iADBC3C60189F33E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48991.1.
    RefSeqiXP_003718575.1. XM_003718527.1.

    Genome annotation databases

    EnsemblFungiiMGG_00487T0; MGG_00487T0; MGG_00487.
    GeneIDi2674708.
    KEGGimgr:MGG_00487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48991.1 .
    RefSeqi XP_003718575.1. XM_003718527.1.

    3D structure databases

    ProteinModelPortali A4RF25.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 148305.A4RF25.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_00487T0 ; MGG_00487T0 ; MGG_00487 .
    GeneIDi 2674708.
    KEGGi mgr:MGG_00487.

    Phylogenomic databases

    eggNOGi COG0339.
    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

    Entry informationi

    Entry nameiPMIP_MAGO7
    AccessioniPrimary (citable) accession number: A4RF25
    Secondary accession number(s): G4NBT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: May 15, 2007
    Last modified: May 14, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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