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A4RF25

- PMIP_MAGO7

UniProt

A4RF25 - PMIP_MAGO7

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi587 – 5871Zinc; catalyticPROSITE-ProRule annotation
Active sitei588 – 5881PROSITE-ProRule annotation
Metal bindingi591 – 5911Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi594 – 5941Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:MGG_00487
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 5

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535MitochondrionSequence AnalysisAdd
BLAST
Chaini36 – 812777Mitochondrial intermediate peptidasePRO_0000338587Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi148305.A4RF25.

Structurei

3D structure databases

ProteinModelPortaliA4RF25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi296 – 2994Poly-Ala

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
InParanoidiA4RF25.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4RF25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKLLRPRPW VCNSCLNRVA FPKPYPVGSR STRWLSTAQS AAPAVSIPPV
60 70 80 90 100
NPVPADHTTS GTHDDALLGK IFDCSSAWRD FSARSAKFPT ENAGLFRNAY
110 120 130 140 150
LTSPDGFLTF AQSSLSKASA IVNRVLGAST IEEYKTIVRD LDRLSDLLCR
160 170 180 190 200
VIDLSDFVRV THPDVRIQRA ASEAWYMVYQ YMNQLNTMTG LNDQLGKAME
210 220 230 240 250
NSDVTKTWSE EEMAVAQLLK LDFMKSAVNL PQAARDRFVD LSQRISEIGS
260 270 280 290 300
DFVNEMAPEQ RRVVLPSSKF QGMDPQIARR FTKHGYMQLP TMSGEAAAAL
310 320 330 340 350
RTVHDEETRK AVYLAIRTAS SRSVGLLEAL LKHRAELADL AGFESYGHMT
360 370 380 390 400
LRDRMMAKTP ESINKFLVEL SKNNAPRVLQ EVDSLLQEKK TLLASPSATL
410 420 430 440 450
NPWDREYYIQ RIRNAQGKNV KHDNFFASYF SVGRVMQGLS RLFTRLYGIR
460 470 480 490 500
FVPRETLPGE KWHPDVRRLD VVSDTDGHVA VLYCDLFYRE DKSPNPAHFT
510 520 530 540 550
IRCSRAISED EISEAAVSTS EGGPAFGSPE SAANDGMAAS RGASGGPLKQ
560 570 580 590 600
LPTIALVCDF PQRDNPLSGS KSKPASLTFA SLETLFHEMG HAIHSVLART
610 620 630 640 650
SFQNVAGTRC ATDLAELPST LMEYFASDPS VLSLFARHAE TDEPLDYDLL
660 670 680 690 700
AERVRSRGRF EGCDTDYQII LAMLDQAYHS PLASSESFDT TRAYHDLQRE
710 720 730 740 750
HSPLGPDPSS TRWQGFFGHL FGYGSTYYSY LFDQVLAERA WKKVFSSGQD
760 770 780 790 800
GAALSREAGE HLKESLLKWG GSREPWRCVS DVLRDERIAG GGEEAMALVG
810
SWGTSNKSTM KH
Length:812
Mass (Da):90,362
Last modified:May 15, 2007 - v1
Checksum:iADBC3C60189F33E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA. Translation: EHA48991.1.
RefSeqiXP_003718575.1. XM_003718527.1.

Genome annotation databases

EnsemblFungiiMGG_00487T0; MGG_00487T0; MGG_00487.
GeneIDi2674708.
KEGGimgr:MGG_00487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA. Translation: EHA48991.1 .
RefSeqi XP_003718575.1. XM_003718527.1.

3D structure databases

ProteinModelPortali A4RF25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 148305.A4RF25.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_00487T0 ; MGG_00487T0 ; MGG_00487 .
GeneIDi 2674708.
KEGGi mgr:MGG_00487.

Phylogenomic databases

eggNOGi COG0339.
InParanoidi A4RF25.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiPMIP_MAGO7
AccessioniPrimary (citable) accession number: A4RF25
Secondary accession number(s): G4NBT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 15, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3