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A4REV8

- 3HAO_MAGO7

UniProt

A4REV8 - 3HAO_MAGO7

Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

    Catalytic activityi

    3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

    Cofactori

    Fe2+ ion.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441DioxygenUniRule annotation
    Metal bindingi48 – 481Iron; catalyticUniRule annotation
    Metal bindingi54 – 541Iron; catalyticUniRule annotation
    Binding sitei54 – 541SubstrateUniRule annotation
    Metal bindingi92 – 921Iron; catalyticUniRule annotation
    Binding sitei96 – 961SubstrateUniRule annotation
    Binding sitei106 – 1061SubstrateUniRule annotation
    Metal bindingi121 – 1211Divalent metal cationUniRule annotation
    Metal bindingi126 – 1261Divalent metal cationUniRule annotation
    Metal bindingi162 – 1621Divalent metal cationUniRule annotation
    Metal bindingi165 – 1651Divalent metal cationUniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
    2. ferrous iron binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    4. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00330.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
    Alternative name(s):
    3-hydroxyanthranilate oxygenaseUniRule annotation
    Short name:
    3-HAOUniRule annotation
    3-hydroxyanthranilic acid dioxygenaseUniRule annotation
    Short name:
    HADUniRule annotation
    Biosynthesis of nicotinic acid protein 1UniRule annotation
    Gene namesi
    Name:BNA1UniRule annotation
    ORF Names:MGG_00549
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 5

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1841843-hydroxyanthranilate 3,4-dioxygenasePRO_0000361989Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi148305.A4REV8.

    Structurei

    3D structure databases

    ProteinModelPortaliA4REV8.
    SMRiA4REV8. Positions 5-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 3-HAO family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG77058.
    KOiK00452.
    OrthoDBiEOG7QK0Q0.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    HAMAPiMF_00825. 3_HAO.
    InterProiIPR010329. 3hydroanth_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR15497. PTHR15497. 1 hit.
    PfamiPF06052. 3-HAO. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4REV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGPPVNLPK WLEENSHLLK PPINNYCVYN DDFTVMIVGG PNARTDYHIN    50
    QTPEWFYQYK GAMMLKVVDD GVFRDIIIRE GDMFLLPGNT PHNPVRFADT 100
    VGVVLEQRRP EGSIDRMRWY CQNPDCTPGQ VVHEASFHCT DLGTQIKAGV 150
    ESFKTDESLR KCGKCGELAD WCPKPGSILD PNKA 184
    Length:184
    Mass (Da):20,798
    Last modified:May 15, 2007 - v1
    Checksum:i0E3F049B9F8B3A4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48917.1.
    RefSeqiXP_003718501.1. XM_003718453.1.

    Genome annotation databases

    EnsemblFungiiMGG_00549T0; MGG_00549T0; MGG_00549.
    GeneIDi2674643.
    KEGGimgr:MGG_00549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48917.1 .
    RefSeqi XP_003718501.1. XM_003718453.1.

    3D structure databases

    ProteinModelPortali A4REV8.
    SMRi A4REV8. Positions 5-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 148305.A4REV8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_00549T0 ; MGG_00549T0 ; MGG_00549 .
    GeneIDi 2674643.
    KEGGi mgr:MGG_00549.

    Phylogenomic databases

    eggNOGi NOG77058.
    KOi K00452.
    OrthoDBi EOG7QK0Q0.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00330 .

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    HAMAPi MF_00825. 3_HAO.
    InterProi IPR010329. 3hydroanth_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR15497. PTHR15497. 1 hit.
    Pfami PF06052. 3-HAO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

    Entry informationi

    Entry namei3HAO_MAGO7
    AccessioniPrimary (citable) accession number: A4REV8
    Secondary accession number(s): G4NBG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3