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A4REV8 (3HAO_MAGO7) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Biosynthesis of nicotinic acid protein 1
Gene names
Name:BNA1
ORF Names:MGG_00549
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome]
Taxonomic identifier242507 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity. HAMAP-Rule MF_03019

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03019.

Sequence similarities

Belongs to the 3-HAO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1841843-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000361989

Sites

Metal binding481Iron; catalytic By similarity
Metal binding541Iron; catalytic By similarity
Metal binding921Iron; catalytic By similarity
Metal binding1211Divalent metal cation By similarity
Metal binding1261Divalent metal cation By similarity
Metal binding1621Divalent metal cation By similarity
Metal binding1651Divalent metal cation By similarity
Binding site441Dioxygen By similarity
Binding site541Substrate By similarity
Binding site961Substrate By similarity
Binding site1061Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A4REV8 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 0E3F049B9F8B3A4D

FASTA18420,798
        10         20         30         40         50         60 
MLGPPVNLPK WLEENSHLLK PPINNYCVYN DDFTVMIVGG PNARTDYHIN QTPEWFYQYK 

        70         80         90        100        110        120 
GAMMLKVVDD GVFRDIIIRE GDMFLLPGNT PHNPVRFADT VGVVLEQRRP EGSIDRMRWY 

       130        140        150        160        170        180 
CQNPDCTPGQ VVHEASFHCT DLGTQIKAGV ESFKTDESLR KCGKCGELAD WCPKPGSILD 


PNKA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM001235 Genomic DNA. Translation: EHA48917.1.
RefSeqXP_003718501.1. XM_003718453.1.

3D structure databases

ProteinModelPortalA4REV8.
SMRA4REV8. Positions 5-168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING148305.A4REV8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiMGG_00549T0; MGG_00549T0; MGG_00549.
GeneID2674643.
KEGGmgr:MGG_00549.

Phylogenomic databases

eggNOGNOG77058.
KOK00452.
OrthoDBEOG7QK0Q0.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_MAGO7
AccessionPrimary (citable) accession number: A4REV8
Secondary accession number(s): G4NBG0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 15, 2007
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways