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A4RE47

- KEX1_MAGO7

UniProt

A4RE47 - KEX1_MAGO7

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei177 – 1771By similarity
    Active sitei378 – 3781By similarity
    Active sitei440 – 4401By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:MGG_00775
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 634610Pheromone-processing carboxypeptidase KEX1PRO_0000411925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi148305.A4RE47.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 512488LumenalSequence AnalysisAdd
    BLAST
    Topological domaini534 – 634101CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei513 – 53321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi534 – 5407Poly-Arg

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A4RE47-1 [UniParc]FASTAAdd to Basket

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    MKLAMRRAST FALLALSWSA AVSAASSAGD YFVRSLPGAP PGPLVKMHAG    50
    HIEVSPEKNG NLFFWHFQNK HIANRQRTVI WLNGGPGCSS EDGALMEVGP 100
    YRLKDDHTLV PNEGSWHEFA NLMFVDNPVG TGFSYVNTDS YVTELDEMAD 150
    QFVIFLEKFF ELFPEYSQDD IYIAGESFAG QHIPYIAKHI LDRNKNSMTK 200
    IKWNLKGLLI GNGWIAPNEQ YRAYLDFSYS KGLLDKNSET AKTLEAQHKD 250
    CAKEWEDNGP KVDVAKCESV LQTLLKLSSK VEADGKRHCV NMYDVRLRDT 300
    YPSCGMNWPP DLVNVTPYLR RKDVVEALHV NPNKATGWTE CTGAVGQSFK 350
    AQKSKPSIDL LPKILEEVPI LLFSGAEDLI CNHIGTEAFI GKMTWNGGKG 400
    FEVTPGTWAP RRDWTFEGKD AGFWQEARNL TYVLFKDSSH MVPFDFPRRS 450
    RDMLDRFMGV DISSIGGNPT DSRLDGEKLP ETTVGGAAGN STSKQEEEKK 500
    KLDEAKWYAY RKSGEVVLVI VAVAAVAWGW YVWRDRRRRR GYQGIFGGSP 550
    SESTTRLPGL GSRISSTPSG LEGFRSKRQN GRDVEAGDFD ESELDDLHTQ 600
    TPTDARYSVG ADSDDEEDAS GSRKEGGPSG GRGR 634
    Length:634
    Mass (Da):70,579
    Last modified:January 25, 2012 - v2
    Checksum:iE7AB2907441E625F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48634.1.
    RefSeqiXP_003718218.1. XM_003718170.1.

    Genome annotation databases

    EnsemblFungiiMGG_00775T0; MGG_00775T0; MGG_00775.
    GeneIDi2675037.
    KEGGimgr:MGG_00775.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48634.1 .
    RefSeqi XP_003718218.1. XM_003718170.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 148305.A4RE47.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_00775T0 ; MGG_00775T0 ; MGG_00775 .
    GeneIDi 2675037.
    KEGGi mgr:MGG_00775.

    Phylogenomic databases

    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

    Entry informationi

    Entry nameiKEX1_MAGO7
    AccessioniPrimary (citable) accession number: A4RE47
    Secondary accession number(s): G4NEK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3