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A4RE47

- KEX1_MAGO7

UniProt

A4RE47 - KEX1_MAGO7

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771By similarity
Active sitei378 – 3781By similarity
Active sitei440 – 4401By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:MGG_00775
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 634610Pheromone-processing carboxypeptidase KEX1PRO_0000411925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi148305.A4RE47.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 512488LumenalSequence AnalysisAdd
BLAST
Topological domaini534 – 634101CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei513 – 53321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi534 – 5407Poly-Arg

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiA4RE47.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4RE47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLAMRRAST FALLALSWSA AVSAASSAGD YFVRSLPGAP PGPLVKMHAG
60 70 80 90 100
HIEVSPEKNG NLFFWHFQNK HIANRQRTVI WLNGGPGCSS EDGALMEVGP
110 120 130 140 150
YRLKDDHTLV PNEGSWHEFA NLMFVDNPVG TGFSYVNTDS YVTELDEMAD
160 170 180 190 200
QFVIFLEKFF ELFPEYSQDD IYIAGESFAG QHIPYIAKHI LDRNKNSMTK
210 220 230 240 250
IKWNLKGLLI GNGWIAPNEQ YRAYLDFSYS KGLLDKNSET AKTLEAQHKD
260 270 280 290 300
CAKEWEDNGP KVDVAKCESV LQTLLKLSSK VEADGKRHCV NMYDVRLRDT
310 320 330 340 350
YPSCGMNWPP DLVNVTPYLR RKDVVEALHV NPNKATGWTE CTGAVGQSFK
360 370 380 390 400
AQKSKPSIDL LPKILEEVPI LLFSGAEDLI CNHIGTEAFI GKMTWNGGKG
410 420 430 440 450
FEVTPGTWAP RRDWTFEGKD AGFWQEARNL TYVLFKDSSH MVPFDFPRRS
460 470 480 490 500
RDMLDRFMGV DISSIGGNPT DSRLDGEKLP ETTVGGAAGN STSKQEEEKK
510 520 530 540 550
KLDEAKWYAY RKSGEVVLVI VAVAAVAWGW YVWRDRRRRR GYQGIFGGSP
560 570 580 590 600
SESTTRLPGL GSRISSTPSG LEGFRSKRQN GRDVEAGDFD ESELDDLHTQ
610 620 630
TPTDARYSVG ADSDDEEDAS GSRKEGGPSG GRGR
Length:634
Mass (Da):70,579
Last modified:January 25, 2012 - v2
Checksum:iE7AB2907441E625F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001235 Genomic DNA. Translation: EHA48634.1.
RefSeqiXP_003718218.1. XM_003718170.1.

Genome annotation databases

EnsemblFungiiMGG_00775T0; MGG_00775T0; MGG_00775.
GeneIDi2675037.
KEGGimgr:MGG_00775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001235 Genomic DNA. Translation: EHA48634.1 .
RefSeqi XP_003718218.1. XM_003718170.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 148305.A4RE47.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_00775T0 ; MGG_00775T0 ; MGG_00775 .
GeneIDi 2675037.
KEGGi mgr:MGG_00775.

Phylogenomic databases

InParanoidi A4RE47.
KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiKEX1_MAGO7
AccessioniPrimary (citable) accession number: A4RE47
Secondary accession number(s): G4NEK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 25, 2012
Last modified: October 29, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3