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A4RDI6

- MAP2_MAGO7

UniProt

A4RDI6 - MAP2_MAGO7

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Protein
Methionine aminopeptidase 2
Gene
MGG_00966
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei196 – 1961Substrate By similarity
Metal bindingi216 – 2161Divalent metal cation 1 By similarity
Metal bindingi227 – 2271Divalent metal cation 1 By similarity
Metal bindingi227 – 2271Divalent metal cation 2; catalytic By similarity
Metal bindingi296 – 2961Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei304 – 3041Substrate By similarity
Metal bindingi329 – 3291Divalent metal cation 2; catalytic By similarity
Metal bindingi424 – 4241Divalent metal cation 1 By similarity
Metal bindingi424 – 4241Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal involved in protein maturation Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2 (EC:3.4.11.18)
Short name:
MAP 2
Short name:
MetAP 2
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:MGG_00966
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 5

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Methionine aminopeptidase 2UniRule annotation
PRO_0000407656Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi148305.A4RDI6.

Structurei

3D structure databases

ProteinModelPortaliA4RDI6.
SMRiA4RDI6. Positions 76-443.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 7114Lys-richUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0024.
KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4RDI6-1 [UniParc]FASTAAdd to Basket

« Hide

MAAQVPTEEL KKLKVAAKSD DPAAANGANG NTANDSDGSD DDDEPEDAGA    50
AAGGEGAKKK KKRKPRKKKK KNANGQTDPP RIPISQLFPD NSYPKGQEVE 100
YLGENTYRTT NEEKRHLDSL NSDLLTDYRH GAEAHRQARR WAHKHVKPGM 150
SLTDIANGIE DSVRALVGHS GLEEGDAIIA GMGFPTGLSI NHCAAHYTPN 200
AGNKMVLEHD DVLKVDIGVH VNGRIVDSAF TVAFNPRYDN LLAAVKDATN 250
TGIREAGIDA RLGEIGEAIQ ETMESYEVEI DGETYPVKPI RNLNGHTIDR 300
YTIHGGKSVP IVKSADQTKM EEGEIYAIET FGSTGLGYVR DEGEVSHYAK 350
RADAPNVALR LTSAQKILNV INKNFGTLPF CRRYLDRLGQ DKYLLGLNNL 400
VSNGIVEAYP PLVDKKGSYT AQYEHTILLR PTVKEVISRG DDY 443
Length:443
Mass (Da):48,388
Last modified:May 15, 2007 - v1
Checksum:i1C082CDAC42FC28A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001235 Genomic DNA. Translation: EHA48400.1.
RefSeqiXP_003717984.1. XM_003717936.1.

Genome annotation databases

EnsemblFungiiMGG_00966T0; MGG_00966T0; MGG_00966.
GeneIDi2674877.
KEGGimgr:MGG_00966.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001235 Genomic DNA. Translation: EHA48400.1 .
RefSeqi XP_003717984.1. XM_003717936.1.

3D structure databases

ProteinModelPortali A4RDI6.
SMRi A4RDI6. Positions 76-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 148305.A4RDI6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_00966T0 ; MGG_00966T0 ; MGG_00966 .
GeneIDi 2674877.
KEGGi mgr:MGG_00966.

Phylogenomic databases

eggNOGi COG0024.
KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiMAP2_MAGO7
AccessioniPrimary (citable) accession number: A4RDI6
Secondary accession number(s): G4ND58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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