Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4RDI6

- MAP2_MAGO7

UniProt

A4RDI6 - MAP2_MAGO7

Protein

Methionine aminopeptidase 2

Gene

MGG_00966

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

    Catalytic activityi

    Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

    Cofactori

    Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei196 – 1961SubstrateUniRule annotation
    Metal bindingi216 – 2161Divalent metal cation 1UniRule annotation
    Metal bindingi227 – 2271Divalent metal cation 1UniRule annotation
    Metal bindingi227 – 2271Divalent metal cation 2; catalyticUniRule annotation
    Metal bindingi296 – 2961Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
    Binding sitei304 – 3041SubstrateUniRule annotation
    Metal bindingi329 – 3291Divalent metal cation 2; catalyticUniRule annotation
    Metal bindingi424 – 4241Divalent metal cation 1UniRule annotation
    Metal bindingi424 – 4241Divalent metal cation 2; catalyticUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-HAMAP
    2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein initiator methionine removal involved in protein maturation Source: EnsemblFungi

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
    Short name:
    MAP 2UniRule annotation
    Short name:
    MetAP 2UniRule annotation
    Alternative name(s):
    Peptidase MUniRule annotation
    Gene namesi
    ORF Names:MGG_00966
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 5

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Methionine aminopeptidase 2PRO_0000407656Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi148305.A4RDI6.

    Structurei

    3D structure databases

    ProteinModelPortaliA4RDI6.
    SMRiA4RDI6. Positions 76-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 7114Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0024.
    KOiK01265.
    OrthoDBiEOG7BGHW3.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.90.230.10. 2 hits.
    HAMAPiMF_03175. MetAP_2_euk.
    InterProiIPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002468. Pept_M24A_MAP2.
    IPR018349. Pept_M24A_MAP2_BS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
    PfamiPF00557. Peptidase_M24. 1 hit.
    [Graphical view]
    PRINTSiPR00599. MAPEPTIDASE.
    SUPFAMiSSF55920. SSF55920. 2 hits.
    TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
    PROSITEiPS01202. MAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4RDI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAQVPTEEL KKLKVAAKSD DPAAANGANG NTANDSDGSD DDDEPEDAGA    50
    AAGGEGAKKK KKRKPRKKKK KNANGQTDPP RIPISQLFPD NSYPKGQEVE 100
    YLGENTYRTT NEEKRHLDSL NSDLLTDYRH GAEAHRQARR WAHKHVKPGM 150
    SLTDIANGIE DSVRALVGHS GLEEGDAIIA GMGFPTGLSI NHCAAHYTPN 200
    AGNKMVLEHD DVLKVDIGVH VNGRIVDSAF TVAFNPRYDN LLAAVKDATN 250
    TGIREAGIDA RLGEIGEAIQ ETMESYEVEI DGETYPVKPI RNLNGHTIDR 300
    YTIHGGKSVP IVKSADQTKM EEGEIYAIET FGSTGLGYVR DEGEVSHYAK 350
    RADAPNVALR LTSAQKILNV INKNFGTLPF CRRYLDRLGQ DKYLLGLNNL 400
    VSNGIVEAYP PLVDKKGSYT AQYEHTILLR PTVKEVISRG DDY 443
    Length:443
    Mass (Da):48,388
    Last modified:May 15, 2007 - v1
    Checksum:i1C082CDAC42FC28A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48400.1.
    RefSeqiXP_003717984.1. XM_003717936.1.

    Genome annotation databases

    EnsemblFungiiMGG_00966T0; MGG_00966T0; MGG_00966.
    GeneIDi2674877.
    KEGGimgr:MGG_00966.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48400.1 .
    RefSeqi XP_003717984.1. XM_003717936.1.

    3D structure databases

    ProteinModelPortali A4RDI6.
    SMRi A4RDI6. Positions 76-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 148305.A4RDI6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_00966T0 ; MGG_00966T0 ; MGG_00966 .
    GeneIDi 2674877.
    KEGGi mgr:MGG_00966.

    Phylogenomic databases

    eggNOGi COG0024.
    KOi K01265.
    OrthoDBi EOG7BGHW3.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.90.230.10. 2 hits.
    HAMAPi MF_03175. MetAP_2_euk.
    InterProi IPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002468. Pept_M24A_MAP2.
    IPR018349. Pept_M24A_MAP2_BS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
    Pfami PF00557. Peptidase_M24. 1 hit.
    [Graphical view ]
    PRINTSi PR00599. MAPEPTIDASE.
    SUPFAMi SSF55920. SSF55920. 2 hits.
    TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
    PROSITEi PS01202. MAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

    Entry informationi

    Entry nameiMAP2_MAGO7
    AccessioniPrimary (citable) accession number: A4RDI6
    Secondary accession number(s): G4ND58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3