A4R8D7 (MCES_MAGO7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
mRNA cap guanine-N7 methyltransferase
EC=2.1.1.56

Alternative name(s):
mRNA (guanine-N(7)-)-methyltransferase
mRNA cap methyltransferase

Gene names

Name:	ABD1
ORF Names:	MGG_06505

Organism

Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome]

Taxonomic identifier

242507 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Magnaporthales › Magnaporthaceae › Magnaporthe

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	mRNA cap guanine-N7 methyltransferase		PRO_0000303911

Sequences

	Sequence		Length	Mass (Da)
	A4R8D7 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: E7A892734D826EFC	FASTA	486	54,649
	10 20 30 40 50 60 MAGGADLDEP PRQSDSTTDR KRPADSTHEI GSADVPRDRA GNKTYDISKL EPARKRQRSK 70 80 90 100 110 120 SPSGEAAPRK LKRPGARATI SEADRKAARE RALERERLAR EAATADEERQ QINDVVKAHY 130 140 150 160 170 180 NAVPERGRDW RKTDSRIKGL RSFNNWIKSC IIQKFSPDED HQPGRGGGPS ILVLDMGCGK 190 200 210 220 230 240 GGDLGKWQQA PQHVELYVGM DPADVSIDQA RDRYRSMSSR GGRGGRGGRG GGRGPARLFE 250 260 270 280 290 300 ARFHVKDCFG EPISDIDIIR QVGFESGPHG GGRGFDVVSM MFCMHYAFET EQKARQMLKN 310 320 330 340 350 360 VAGALRKGGR LIGAIPNSDV ISTKVREHNE RMVEMKKKQA EAGDGSKKDD GGDAEEGELD 370 380 390 400 410 420 EPEVEKSAEW GNDIYRVRFP GKTPEDGIFR PPFGWKYNFF LHEAVEEVPE YVVPWEAFRA 430 440 450 460 470 480 LAEDYNLELQ WHRSFKEIWD QEKDDRTLGP LSERMHVRDR NTGELLVSPE ELEAANFYVG FCFYKV

References

[1]

"The genome sequence of the rice blast fungus Magnaporthe grisea." Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., Soanes D.M. , Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W. Nature 434:980-986(2005) [PubMed: 15846337] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CM001234 Genomic DNA. Translation: EHA50735.1.
RefSeq	XP_369990.1. XM_369990.1.
3D structure databases
ProteinModelPortal	A4R8D7.
ModBase	Search...
Protein-protein interaction databases
STRING	A4R8D7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2684660.
KEGG	mgr:MGG_06505.
NMPDR	fig|242507.1.peg.10568.
Phylogenomic databases
OrthoDB	EOG4JMBZ5.
Family and domain databases
InterPro	IPR016899. mRNA_G-N7_MeTrfase. IPR004971. Pox_MCEL. [Graphical view]
KO	K00565.
Pfam	PF03291. Pox_MCEL. 2 hits. [Graphical view]
PIRSF	PIRSF028762. ABD1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCES_MAGO7

Accession

Primary (citable) accession number: A4R8D7
Secondary accession number(s): G4N6X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program