ID   EIF3B_PYRO7             Reviewed;         746 AA.
AC   A4QZL9; G4MMB8;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE            Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE   AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE            Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE   AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN   Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=MGG_01978;
OS   Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Magnaporthe oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC       Rule:MF_03001}.
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DR   EMBL; CM001231; EHA56104.1; -; Genomic_DNA.
DR   RefSeq; XP_003708716.1; XM_003708668.1.
DR   AlphaFoldDB; A4QZL9; -.
DR   SMR; A4QZL9; -.
DR   STRING; 242507.A4QZL9; -.
DR   EnsemblFungi; MGG_01978T0; MGG_01978T0; MGG_01978.
DR   GeneID; 2681097; -.
DR   KEGG; mgr:MGG_01978; -.
DR   VEuPathDB; FungiDB:MGG_01978; -.
DR   eggNOG; KOG2314; Eukaryota.
DR   HOGENOM; CLU_011152_4_0_1; -.
DR   InParanoid; A4QZL9; -.
DR   OMA; LWGGPQF; -.
DR   OrthoDB; 5479191at2759; -.
DR   Proteomes; UP000009058; Chromosome 1.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR   GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd12278; RRM_eIF3B; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   HAMAP; MF_03001; eIF3b; 1.
DR   InterPro; IPR011400; EIF3B.
DR   InterPro; IPR034363; eIF3B_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR14068; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED; 1.
DR   PANTHER; PTHR14068:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   PIRSF; PIRSF036424; eIF3b; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; RNA-binding; WD repeat.
FT   CHAIN           1..746
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   B"
FT                   /id="PRO_0000363821"
FT   DOMAIN          42..128
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT   REPEAT          195..234
FT                   /note="WD 1"
FT   REPEAT          247..294
FT                   /note="WD 2"
FT   REPEAT          307..346
FT                   /note="WD 3"
FT   REPEAT          349..386
FT                   /note="WD 4"
FT   REPEAT          458..500
FT                   /note="WD 5"
FT   REPEAT          517..560
FT                   /note="WD 6"
FT   REPEAT          575..620
FT                   /note="WD 7"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   746 AA;  85759 MW;  6EC70B567FECD6C9 CRC64;
     MAPSYEHLRE ADLDEDEFDE DEVDVSDLRE KFEVQLEQGF DTFVVIDGLP EVTEEQKPKL
     VKFLLKKLTS VGKTKEDMID MPMGPDGKSL RFAFVEYSSP GEAAAAVRQL DRVPLDKKHT
     LRVNKLMDVD RFGREGRIDD EYQPPHIDEF HPRDHLRSFM ADPSGRGRDQ FVMFRGDHVG
     VFWNNEKDTP ENIVDRPNWT ESFVQWSPLG TYLLSMHMQG VQLWGGPKWD RLGRFPHPFV
     NMAAFSPQEN YLVTWSNRPI SIPDEGHPAL SMDDDGKNYV IWDIATGKPL RSFANLDLPP
     DDPNKPPRKH PWPAFKWSSD DKYVARLTQG QSISVYELPR MNLLDKTTIK VEGVQDFEWA
     PSRPQRDGVK TYEQMFCYWT PEIGSNPAKV GLMSIPSKEV VRSLNLFSVS DVKLHWQSEG
     AYLCVKVDRH SKSKKSQATT LEIFRVKEKG VPVEVVDTIK DTVINFAWEP KGDRFLIITT
     VTPTGEVAVQ PKTAISFFCP EKSKGSTVGN FKHLRTLDKR NSNAIYWSPK GRFVVVATVH
     NQNSSDLDFF DLDFEGEKPE GEKDLTANLQ LMNTADHYGI TDVEWDPSGR FVATWASAWK
     HTMENGYHMY DFKGEQLREE AVEKFKQLQW RPRPPTLLAK EEQKQIRKNL REYSRVFEQE
     DAERIAGADQ EVVDNRRRIL EDWYEWRESV DVEVDEESAA MGVSSNPAEE LLKAKTAEIL
     ASGQEEEQVI EEIVEEVLEE SEEIVS
//