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A4QXX4 (SSN3_MAGO7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
ORF Names:MGG_13931
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome]
Taxonomic identifier242507 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Serine/threonine-protein kinase SSN3
PRO_0000312947

Regions

Domain61 – 442382Protein kinase
Nucleotide binding67 – 759ATP By similarity

Sites

Active site1931Proton acceptor By similarity
Binding site911ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QXX4 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 4D6D22BA3A00FAA1

FASTA49955,094
        10         20         30         40         50         60 
MSHSNPPTGA SGGPGSASAS AAPARGYYSL KRSIQTAFND PLDRGLGPPA YQSKVRVMDK 

        70         80         90        100        110        120 
YQVIGFISSG TYGRVYKARG RQGQPGEFAI KKFKPDKEGE QITYTGISQS AIREMALCSE 

       130        140        150        160        170        180 
LRHPNVIRLV ETILEDKAIF MVFEYAEHDL LQIIHHHTQQ PKHPIPPQTI KSIMFQLLNG 

       190        200        210        220        230        240 
CQYLHTNWVL HRDLKPANIM VTSSGEVKVG DLGLARIFWK PVRTLMQGDK VVVTIWYRAP 

       250        260        270        280        290        300 
ELLMGSHHYT PAVDMWAVGC IFAELLSLRP IFKGEEAKMD NTKKGGSRDM PFQRHQMQKI 

       310        320        330        340        350        360 
VDIMGMPTKE RWPLLTSMPD YDKLPLLQPP LSASGYSQQP AHSHHHHQHY NQGPQYGGRA 

       370        380        390        400        410        420 
GGPTSSSSAN SSSAAAAASQ SHLDKWYYHT VSQGQTAGPM PHAPPGSLAS LGVEGYKLLA 

       430        440        450        460        470        480 
GLLEYDPEKR LTAAAALQHN FFSTGDRVSA NCFEGCKAEY PHRRVSQEDN DIRTGSVPGT 

       490 
KRSGMPDDSM GRPGKRVKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM001234 Genomic DNA. Translation: EHA49585.1.
RefSeqXP_003715904.1. XM_003715856.1.

3D structure databases

ProteinModelPortalA4QXX4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING148305.A4QXX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiMGG_13931T0; MGG_13931T0; MGG_13931.
GeneID5049253.
KEGGmgr:MGG_13931.

Phylogenomic databases

eggNOGCOG0515.
KOK02208.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_MAGO7
AccessionPrimary (citable) accession number: A4QXX4
Secondary accession number(s): G4N9S7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families