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A4QXX4

- SSN3_MAGO7

UniProt

A4QXX4 - SSN3_MAGO7

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Protein
Serine/threonine-protein kinase SSN3
Gene
SSN3, CDK8, MGG_13931
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911ATP By similarity
Active sitei193 – 1931Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 759ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
ORF Names:MGG_13931
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 4

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Serine/threonine-protein kinase SSN3
PRO_0000312947Add
BLAST

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Protein-protein interaction databases

STRINGi148305.A4QXX4.

Structurei

3D structure databases

ProteinModelPortaliA4QXX4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 442382Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
KOiK02208.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QXX4-1 [UniParc]FASTAAdd to Basket

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MSHSNPPTGA SGGPGSASAS AAPARGYYSL KRSIQTAFND PLDRGLGPPA    50
YQSKVRVMDK YQVIGFISSG TYGRVYKARG RQGQPGEFAI KKFKPDKEGE 100
QITYTGISQS AIREMALCSE LRHPNVIRLV ETILEDKAIF MVFEYAEHDL 150
LQIIHHHTQQ PKHPIPPQTI KSIMFQLLNG CQYLHTNWVL HRDLKPANIM 200
VTSSGEVKVG DLGLARIFWK PVRTLMQGDK VVVTIWYRAP ELLMGSHHYT 250
PAVDMWAVGC IFAELLSLRP IFKGEEAKMD NTKKGGSRDM PFQRHQMQKI 300
VDIMGMPTKE RWPLLTSMPD YDKLPLLQPP LSASGYSQQP AHSHHHHQHY 350
NQGPQYGGRA GGPTSSSSAN SSSAAAAASQ SHLDKWYYHT VSQGQTAGPM 400
PHAPPGSLAS LGVEGYKLLA GLLEYDPEKR LTAAAALQHN FFSTGDRVSA 450
NCFEGCKAEY PHRRVSQEDN DIRTGSVPGT KRSGMPDDSM GRPGKRVKE 499
Length:499
Mass (Da):55,094
Last modified:January 15, 2008 - v2
Checksum:i4D6D22BA3A00FAA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001234 Genomic DNA. Translation: EHA49585.1.
RefSeqiXP_003715904.1. XM_003715856.1.

Genome annotation databases

EnsemblFungiiMGG_13931T0; MGG_13931T0; MGG_13931.
GeneIDi5049253.
KEGGimgr:MGG_13931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001234 Genomic DNA. Translation: EHA49585.1 .
RefSeqi XP_003715904.1. XM_003715856.1.

3D structure databases

ProteinModelPortali A4QXX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 148305.A4QXX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_13931T0 ; MGG_13931T0 ; MGG_13931 .
GeneIDi 5049253.
KEGGi mgr:MGG_13931.

Phylogenomic databases

eggNOGi COG0515.
KOi K02208.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiSSN3_MAGO7
AccessioniPrimary (citable) accession number: A4QXX4
Secondary accession number(s): G4N9S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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