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A4QXX4

- SSN3_MAGO7

UniProt

A4QXX4 - SSN3_MAGO7

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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911ATPPROSITE-ProRule annotation
Active sitei193 – 1931Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 759ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
ORF Names:MGG_13931
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 4

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Serine/threonine-protein kinase SSN3PRO_0000312947Add
BLAST

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi148305.A4QXX4.

Structurei

3D structure databases

ProteinModelPortaliA4QXX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 442382Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiA4QXX4.
KOiK02208.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QXX4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHSNPPTGA SGGPGSASAS AAPARGYYSL KRSIQTAFND PLDRGLGPPA
60 70 80 90 100
YQSKVRVMDK YQVIGFISSG TYGRVYKARG RQGQPGEFAI KKFKPDKEGE
110 120 130 140 150
QITYTGISQS AIREMALCSE LRHPNVIRLV ETILEDKAIF MVFEYAEHDL
160 170 180 190 200
LQIIHHHTQQ PKHPIPPQTI KSIMFQLLNG CQYLHTNWVL HRDLKPANIM
210 220 230 240 250
VTSSGEVKVG DLGLARIFWK PVRTLMQGDK VVVTIWYRAP ELLMGSHHYT
260 270 280 290 300
PAVDMWAVGC IFAELLSLRP IFKGEEAKMD NTKKGGSRDM PFQRHQMQKI
310 320 330 340 350
VDIMGMPTKE RWPLLTSMPD YDKLPLLQPP LSASGYSQQP AHSHHHHQHY
360 370 380 390 400
NQGPQYGGRA GGPTSSSSAN SSSAAAAASQ SHLDKWYYHT VSQGQTAGPM
410 420 430 440 450
PHAPPGSLAS LGVEGYKLLA GLLEYDPEKR LTAAAALQHN FFSTGDRVSA
460 470 480 490
NCFEGCKAEY PHRRVSQEDN DIRTGSVPGT KRSGMPDDSM GRPGKRVKE
Length:499
Mass (Da):55,094
Last modified:January 15, 2008 - v2
Checksum:i4D6D22BA3A00FAA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001234 Genomic DNA. Translation: EHA49585.1.
RefSeqiXP_003715904.1. XM_003715856.1.

Genome annotation databases

EnsemblFungiiMGG_13931T0; MGG_13931T0; MGG_13931.
GeneIDi5049253.
KEGGimgr:MGG_13931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001234 Genomic DNA. Translation: EHA49585.1 .
RefSeqi XP_003715904.1. XM_003715856.1.

3D structure databases

ProteinModelPortali A4QXX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 148305.A4QXX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_13931T0 ; MGG_13931T0 ; MGG_13931 .
GeneIDi 5049253.
KEGGi mgr:MGG_13931.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi A4QXX4.
KOi K02208.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiSSN3_MAGO7
AccessioniPrimary (citable) accession number: A4QXX4
Secondary accession number(s): G4N9S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3