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A4QVZ8

- NTE1_MAGO7

UniProt

A4QVZ8 - NTE1_MAGO7

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1233 – 12331By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi658 – 777120cNMP 1Add
    BLAST
    Nucleotide bindingi821 – 941121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    ORF Names:MGG_06143
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15031503Lysophospholipase NTE1PRO_0000295324Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi148305.A4QVZ8.

    Structurei

    3D structure databases

    ProteinModelPortaliA4QVZ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525CytoplasmicBy similarityAdd
    BLAST
    Topological domaini47 – 7125LumenalBy similarityAdd
    BLAST
    Topological domaini93 – 15031411CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1200 – 1364165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1231 – 12355GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    KOiK14676.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4QVZ8-1 [UniParc]FASTAAdd to Basket

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    MDSSTAALAT ASAKLDAVAQ QGSSSWIGFF ANIILGIISL VYSILYSVLK     50
    LTTFSIPSLL YTLFSTSLTV TMNATTLMLI IVLVFSLVSW FVRYRYLNMY 100
    SRLPPEPQRK EPDVDLFPDT HPGGSKPGLS NYLDEFLSAI KIFGYLERPV 150
    FHELTRSMQT RKLIAGETFN LEEEKGFCMV VDGLVEIFVK SARTGQHPVG 200
    ESCSIDSDGS DEHEEYQAGN QRYQLLTEVH NGAPMSSLFS IMSLFTEDIK 250
    LRHGGDEGGE PTSATETYTS SRYGLGNDFS DQRESTVSVP TTPQLERSSS 300
    HGPTLHDGDA NPSMGGRVPA SIPPMSLDPP LQSRPKRPTT SRHATTSVHP 350
    DIIARATVDT TIAIIPASAF RRLIQIYPKY TAHIVHVILS RFQRVTLATA 400
    YNYLGLTSEV LHIEKSMIDN ATCQLPNFLR GDALTRLKEK FNHERERIGE 450
    KDCTKGIALH NSSTGRRRKS TASLRKEAAL QAITHGQRPS SVTASPPLQP 500
    RESGNKHTSN SGDLLMNIQL SRNGGRRSTS NMDPLTRQST LLGSLETEVV 550
    SPLSQRTSNP FETRRHAHIS LNKRETRDED GLFRESILEC MFKAIGLTAN 600
    GTGAREPDSA DASPRLTSYD QIRRGGYSSH NAFGFIDPYG GSVDGDADSI 650
    TSGGTGPGLP VNPHALAHDM RDEVEIVFFP SGSVLVEQGE RNPGLYYVVD 700
    GFLDVCMSAA DESSGDILKA SKNESSLNIG PGNQQGSAGR DRFMDANLGQ 750
    SSSRKRASNV RRNVALIKPG GLAGYVGSIS SHRSFIDVVA KTDVYVGFLP 800
    RQSLERIVDR YPIVLLTMAK RLTNLLPKLI LHIDFALEWL QVNAGEVIFH 850
    GGEESEAIYI VLNGRLRLVE DRQEGGVDVR GEFGQGESIG ELEVLTESAR 900
    SGTLHAIRNT ELVKFPRTLF NSLAQEHPNI TIKISKIIAS RMRKVVDDPS 950
    TFVGKEGALK ASLNKSSSTL NLRTVAILPV TSGVPVVEFG NRLMGALTQV 1000
    GTPNGATSLS QSAILNHLGR HAFNKMGKLK LSQYLADLEE KYGLVMYVAD 1050
    TNVNSPWTQT CITQADCILL VGLAEGSPEI GEYERFMLGM KSTARKVLVL 1100
    LHADRYAEPG LTRSWLRNRM WINGGHHHVQ MAFRTQSVPI NPTAKRTGPS 1150
    LKERVQILQA EIQKYTSRKV RHSPFYSPDA PFKGDFHRLA RRLCGKSVGL 1200
    VLGGGGARGL AHIGIIRAME ESGIPIDIVG GTSIGSFVGA LYARHADVVP 1250
    IFGLSKKFAG RMASVWRFAL DLTYPSASYT TGHEFNRGIF KTFGKAQIED 1300
    FWLEFYCNTT NISKSRQEIH TSGYAWRYVR ASMSLAGLLP PLCDEGSMLL 1350
    DGGYIDNLTV SHMKSLGVDI IFAVDVGSLD DDVPQAYGDT LSGLWAFVNR 1400
    WNPLSSTPNP PTLAEIQARL AYVSSVDALE RAKMTPGCVY MRPPIDEYGT 1450
    LEFGRFDEIV QVGYKYGLEF LQKLRDEGAL PVVEETEAKK ALRRTMAPRR 1500
    ASI 1503
    Length:1,503
    Mass (Da):165,037
    Last modified:July 24, 2007 - v2
    Checksum:i3CC03B000E44724B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001233 Genomic DNA. Translation: EHA52211.1.
    RefSeqiXP_003712018.1. XM_003711970.1.

    Genome annotation databases

    EnsemblFungiiMGG_06143T0; MGG_06143T0; MGG_06143.
    GeneIDi2684255.
    KEGGimgr:MGG_06143.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001233 Genomic DNA. Translation: EHA52211.1 .
    RefSeqi XP_003712018.1. XM_003711970.1.

    3D structure databases

    ProteinModelPortali A4QVZ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 148305.A4QVZ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_06143T0 ; MGG_06143T0 ; MGG_06143 .
    GeneIDi 2684255.
    KEGGi mgr:MGG_06143.

    Phylogenomic databases

    eggNOGi COG0664.
    KOi K14676.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

    Entry informationi

    Entry nameiNTE1_MAGO7
    AccessioniPrimary (citable) accession number: A4QVZ8
    Secondary accession number(s): G4N5L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3