Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4QVZ8 (NTE1_MAGO7) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
ORF Names:MGG_06143
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome]
Taxonomic identifier242507 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe

Protein attributes

Sequence length1503 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15031503Lysophospholipase NTE1
PRO_0000295324

Regions

Topological domain1 – 2525Cytoplasmic By similarity
Transmembrane26 – 4621Helical; Potential
Topological domain47 – 7125Lumenal By similarity
Transmembrane72 – 9221Helical; Potential
Topological domain93 – 15031411Cytoplasmic By similarity
Domain1200 – 1364165Patatin
Nucleotide binding658 – 777120cNMP 1
Nucleotide binding821 – 941121cNMP 2
Motif1231 – 12355GXSXG

Sites

Active site12331 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QVZ8 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 3CC03B000E44724B

FASTA1,503165,037
        10         20         30         40         50         60 
MDSSTAALAT ASAKLDAVAQ QGSSSWIGFF ANIILGIISL VYSILYSVLK LTTFSIPSLL 

        70         80         90        100        110        120 
YTLFSTSLTV TMNATTLMLI IVLVFSLVSW FVRYRYLNMY SRLPPEPQRK EPDVDLFPDT 

       130        140        150        160        170        180 
HPGGSKPGLS NYLDEFLSAI KIFGYLERPV FHELTRSMQT RKLIAGETFN LEEEKGFCMV 

       190        200        210        220        230        240 
VDGLVEIFVK SARTGQHPVG ESCSIDSDGS DEHEEYQAGN QRYQLLTEVH NGAPMSSLFS 

       250        260        270        280        290        300 
IMSLFTEDIK LRHGGDEGGE PTSATETYTS SRYGLGNDFS DQRESTVSVP TTPQLERSSS 

       310        320        330        340        350        360 
HGPTLHDGDA NPSMGGRVPA SIPPMSLDPP LQSRPKRPTT SRHATTSVHP DIIARATVDT 

       370        380        390        400        410        420 
TIAIIPASAF RRLIQIYPKY TAHIVHVILS RFQRVTLATA YNYLGLTSEV LHIEKSMIDN 

       430        440        450        460        470        480 
ATCQLPNFLR GDALTRLKEK FNHERERIGE KDCTKGIALH NSSTGRRRKS TASLRKEAAL 

       490        500        510        520        530        540 
QAITHGQRPS SVTASPPLQP RESGNKHTSN SGDLLMNIQL SRNGGRRSTS NMDPLTRQST 

       550        560        570        580        590        600 
LLGSLETEVV SPLSQRTSNP FETRRHAHIS LNKRETRDED GLFRESILEC MFKAIGLTAN 

       610        620        630        640        650        660 
GTGAREPDSA DASPRLTSYD QIRRGGYSSH NAFGFIDPYG GSVDGDADSI TSGGTGPGLP 

       670        680        690        700        710        720 
VNPHALAHDM RDEVEIVFFP SGSVLVEQGE RNPGLYYVVD GFLDVCMSAA DESSGDILKA 

       730        740        750        760        770        780 
SKNESSLNIG PGNQQGSAGR DRFMDANLGQ SSSRKRASNV RRNVALIKPG GLAGYVGSIS 

       790        800        810        820        830        840 
SHRSFIDVVA KTDVYVGFLP RQSLERIVDR YPIVLLTMAK RLTNLLPKLI LHIDFALEWL 

       850        860        870        880        890        900 
QVNAGEVIFH GGEESEAIYI VLNGRLRLVE DRQEGGVDVR GEFGQGESIG ELEVLTESAR 

       910        920        930        940        950        960 
SGTLHAIRNT ELVKFPRTLF NSLAQEHPNI TIKISKIIAS RMRKVVDDPS TFVGKEGALK 

       970        980        990       1000       1010       1020 
ASLNKSSSTL NLRTVAILPV TSGVPVVEFG NRLMGALTQV GTPNGATSLS QSAILNHLGR 

      1030       1040       1050       1060       1070       1080 
HAFNKMGKLK LSQYLADLEE KYGLVMYVAD TNVNSPWTQT CITQADCILL VGLAEGSPEI 

      1090       1100       1110       1120       1130       1140 
GEYERFMLGM KSTARKVLVL LHADRYAEPG LTRSWLRNRM WINGGHHHVQ MAFRTQSVPI 

      1150       1160       1170       1180       1190       1200 
NPTAKRTGPS LKERVQILQA EIQKYTSRKV RHSPFYSPDA PFKGDFHRLA RRLCGKSVGL 

      1210       1220       1230       1240       1250       1260 
VLGGGGARGL AHIGIIRAME ESGIPIDIVG GTSIGSFVGA LYARHADVVP IFGLSKKFAG 

      1270       1280       1290       1300       1310       1320 
RMASVWRFAL DLTYPSASYT TGHEFNRGIF KTFGKAQIED FWLEFYCNTT NISKSRQEIH 

      1330       1340       1350       1360       1370       1380 
TSGYAWRYVR ASMSLAGLLP PLCDEGSMLL DGGYIDNLTV SHMKSLGVDI IFAVDVGSLD 

      1390       1400       1410       1420       1430       1440 
DDVPQAYGDT LSGLWAFVNR WNPLSSTPNP PTLAEIQARL AYVSSVDALE RAKMTPGCVY 

      1450       1460       1470       1480       1490       1500 
MRPPIDEYGT LEFGRFDEIV QVGYKYGLEF LQKLRDEGAL PVVEETEAKK ALRRTMAPRR 


ASI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM001233 Genomic DNA. Translation: EHA52211.1.
RefSeqXP_003712018.1. XM_003711970.1.

3D structure databases

ProteinModelPortalA4QVZ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING148305.A4QVZ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiMGG_06143T0; MGG_06143T0; MGG_06143.
GeneID2684255.
KEGGmgr:MGG_06143.

Phylogenomic databases

eggNOGCOG0664.
KOK14676.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_MAGO7
AccessionPrimary (citable) accession number: A4QVZ8
Secondary accession number(s): G4N5L8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families