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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1233 – 12331By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi658 – 777120cNMP 1Add
BLAST
Nucleotide bindingi821 – 941121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phosphatidylcholine catabolic process Source: EnsemblFungi
  2. regulation of phospholipid biosynthetic process Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:MGG_06143
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicBy similarityAdd
BLAST
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Topological domaini47 – 7125LumenalBy similarityAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Topological domaini93 – 15031411CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15031503Lysophospholipase NTE1PRO_0000295324Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi148305.A4QVZ8.

Structurei

3D structure databases

ProteinModelPortaliA4QVZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1200 – 1364165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1231 – 12355GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiA4QVZ8.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QVZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSTAALAT ASAKLDAVAQ QGSSSWIGFF ANIILGIISL VYSILYSVLK
60 70 80 90 100
LTTFSIPSLL YTLFSTSLTV TMNATTLMLI IVLVFSLVSW FVRYRYLNMY
110 120 130 140 150
SRLPPEPQRK EPDVDLFPDT HPGGSKPGLS NYLDEFLSAI KIFGYLERPV
160 170 180 190 200
FHELTRSMQT RKLIAGETFN LEEEKGFCMV VDGLVEIFVK SARTGQHPVG
210 220 230 240 250
ESCSIDSDGS DEHEEYQAGN QRYQLLTEVH NGAPMSSLFS IMSLFTEDIK
260 270 280 290 300
LRHGGDEGGE PTSATETYTS SRYGLGNDFS DQRESTVSVP TTPQLERSSS
310 320 330 340 350
HGPTLHDGDA NPSMGGRVPA SIPPMSLDPP LQSRPKRPTT SRHATTSVHP
360 370 380 390 400
DIIARATVDT TIAIIPASAF RRLIQIYPKY TAHIVHVILS RFQRVTLATA
410 420 430 440 450
YNYLGLTSEV LHIEKSMIDN ATCQLPNFLR GDALTRLKEK FNHERERIGE
460 470 480 490 500
KDCTKGIALH NSSTGRRRKS TASLRKEAAL QAITHGQRPS SVTASPPLQP
510 520 530 540 550
RESGNKHTSN SGDLLMNIQL SRNGGRRSTS NMDPLTRQST LLGSLETEVV
560 570 580 590 600
SPLSQRTSNP FETRRHAHIS LNKRETRDED GLFRESILEC MFKAIGLTAN
610 620 630 640 650
GTGAREPDSA DASPRLTSYD QIRRGGYSSH NAFGFIDPYG GSVDGDADSI
660 670 680 690 700
TSGGTGPGLP VNPHALAHDM RDEVEIVFFP SGSVLVEQGE RNPGLYYVVD
710 720 730 740 750
GFLDVCMSAA DESSGDILKA SKNESSLNIG PGNQQGSAGR DRFMDANLGQ
760 770 780 790 800
SSSRKRASNV RRNVALIKPG GLAGYVGSIS SHRSFIDVVA KTDVYVGFLP
810 820 830 840 850
RQSLERIVDR YPIVLLTMAK RLTNLLPKLI LHIDFALEWL QVNAGEVIFH
860 870 880 890 900
GGEESEAIYI VLNGRLRLVE DRQEGGVDVR GEFGQGESIG ELEVLTESAR
910 920 930 940 950
SGTLHAIRNT ELVKFPRTLF NSLAQEHPNI TIKISKIIAS RMRKVVDDPS
960 970 980 990 1000
TFVGKEGALK ASLNKSSSTL NLRTVAILPV TSGVPVVEFG NRLMGALTQV
1010 1020 1030 1040 1050
GTPNGATSLS QSAILNHLGR HAFNKMGKLK LSQYLADLEE KYGLVMYVAD
1060 1070 1080 1090 1100
TNVNSPWTQT CITQADCILL VGLAEGSPEI GEYERFMLGM KSTARKVLVL
1110 1120 1130 1140 1150
LHADRYAEPG LTRSWLRNRM WINGGHHHVQ MAFRTQSVPI NPTAKRTGPS
1160 1170 1180 1190 1200
LKERVQILQA EIQKYTSRKV RHSPFYSPDA PFKGDFHRLA RRLCGKSVGL
1210 1220 1230 1240 1250
VLGGGGARGL AHIGIIRAME ESGIPIDIVG GTSIGSFVGA LYARHADVVP
1260 1270 1280 1290 1300
IFGLSKKFAG RMASVWRFAL DLTYPSASYT TGHEFNRGIF KTFGKAQIED
1310 1320 1330 1340 1350
FWLEFYCNTT NISKSRQEIH TSGYAWRYVR ASMSLAGLLP PLCDEGSMLL
1360 1370 1380 1390 1400
DGGYIDNLTV SHMKSLGVDI IFAVDVGSLD DDVPQAYGDT LSGLWAFVNR
1410 1420 1430 1440 1450
WNPLSSTPNP PTLAEIQARL AYVSSVDALE RAKMTPGCVY MRPPIDEYGT
1460 1470 1480 1490 1500
LEFGRFDEIV QVGYKYGLEF LQKLRDEGAL PVVEETEAKK ALRRTMAPRR

ASI
Length:1,503
Mass (Da):165,037
Last modified:July 23, 2007 - v2
Checksum:i3CC03B000E44724B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001233 Genomic DNA. Translation: EHA52211.1.
RefSeqiXP_003712018.1. XM_003711970.1.

Genome annotation databases

EnsemblFungiiMGG_06143T0; MGG_06143T0; MGG_06143.
GeneIDi2684255.
KEGGimgr:MGG_06143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001233 Genomic DNA. Translation: EHA52211.1.
RefSeqiXP_003712018.1. XM_003711970.1.

3D structure databases

ProteinModelPortaliA4QVZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi148305.A4QVZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiMGG_06143T0; MGG_06143T0; MGG_06143.
GeneIDi2684255.
KEGGimgr:MGG_06143.

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiA4QVZ8.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiNTE1_MAGO7
AccessioniPrimary (citable) accession number: A4QVZ8
Secondary accession number(s): G4N5L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 23, 2007
Last sequence update: July 23, 2007
Last modified: March 31, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.