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A4QVZ8

- NTE1_MAGO7

UniProt

A4QVZ8 - NTE1_MAGO7

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Protein

Lysophospholipase NTE1

Gene
NTE1, MGG_06143
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1233 – 12331 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi658 – 777120cNMP 1Add
BLAST
Nucleotide bindingi821 – 941121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:MGG_06143
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Cytoplasmic By similarityAdd
BLAST
Transmembranei26 – 4621Helical; Reviewed predictionAdd
BLAST
Topological domaini47 – 7125Lumenal By similarityAdd
BLAST
Transmembranei72 – 9221Helical; Reviewed predictionAdd
BLAST
Topological domaini93 – 15031411Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15031503Lysophospholipase NTE1PRO_0000295324Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi148305.A4QVZ8.

Structurei

3D structure databases

ProteinModelPortaliA4QVZ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1200 – 1364165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1231 – 12355GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QVZ8-1 [UniParc]FASTAAdd to Basket

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MDSSTAALAT ASAKLDAVAQ QGSSSWIGFF ANIILGIISL VYSILYSVLK     50
LTTFSIPSLL YTLFSTSLTV TMNATTLMLI IVLVFSLVSW FVRYRYLNMY 100
SRLPPEPQRK EPDVDLFPDT HPGGSKPGLS NYLDEFLSAI KIFGYLERPV 150
FHELTRSMQT RKLIAGETFN LEEEKGFCMV VDGLVEIFVK SARTGQHPVG 200
ESCSIDSDGS DEHEEYQAGN QRYQLLTEVH NGAPMSSLFS IMSLFTEDIK 250
LRHGGDEGGE PTSATETYTS SRYGLGNDFS DQRESTVSVP TTPQLERSSS 300
HGPTLHDGDA NPSMGGRVPA SIPPMSLDPP LQSRPKRPTT SRHATTSVHP 350
DIIARATVDT TIAIIPASAF RRLIQIYPKY TAHIVHVILS RFQRVTLATA 400
YNYLGLTSEV LHIEKSMIDN ATCQLPNFLR GDALTRLKEK FNHERERIGE 450
KDCTKGIALH NSSTGRRRKS TASLRKEAAL QAITHGQRPS SVTASPPLQP 500
RESGNKHTSN SGDLLMNIQL SRNGGRRSTS NMDPLTRQST LLGSLETEVV 550
SPLSQRTSNP FETRRHAHIS LNKRETRDED GLFRESILEC MFKAIGLTAN 600
GTGAREPDSA DASPRLTSYD QIRRGGYSSH NAFGFIDPYG GSVDGDADSI 650
TSGGTGPGLP VNPHALAHDM RDEVEIVFFP SGSVLVEQGE RNPGLYYVVD 700
GFLDVCMSAA DESSGDILKA SKNESSLNIG PGNQQGSAGR DRFMDANLGQ 750
SSSRKRASNV RRNVALIKPG GLAGYVGSIS SHRSFIDVVA KTDVYVGFLP 800
RQSLERIVDR YPIVLLTMAK RLTNLLPKLI LHIDFALEWL QVNAGEVIFH 850
GGEESEAIYI VLNGRLRLVE DRQEGGVDVR GEFGQGESIG ELEVLTESAR 900
SGTLHAIRNT ELVKFPRTLF NSLAQEHPNI TIKISKIIAS RMRKVVDDPS 950
TFVGKEGALK ASLNKSSSTL NLRTVAILPV TSGVPVVEFG NRLMGALTQV 1000
GTPNGATSLS QSAILNHLGR HAFNKMGKLK LSQYLADLEE KYGLVMYVAD 1050
TNVNSPWTQT CITQADCILL VGLAEGSPEI GEYERFMLGM KSTARKVLVL 1100
LHADRYAEPG LTRSWLRNRM WINGGHHHVQ MAFRTQSVPI NPTAKRTGPS 1150
LKERVQILQA EIQKYTSRKV RHSPFYSPDA PFKGDFHRLA RRLCGKSVGL 1200
VLGGGGARGL AHIGIIRAME ESGIPIDIVG GTSIGSFVGA LYARHADVVP 1250
IFGLSKKFAG RMASVWRFAL DLTYPSASYT TGHEFNRGIF KTFGKAQIED 1300
FWLEFYCNTT NISKSRQEIH TSGYAWRYVR ASMSLAGLLP PLCDEGSMLL 1350
DGGYIDNLTV SHMKSLGVDI IFAVDVGSLD DDVPQAYGDT LSGLWAFVNR 1400
WNPLSSTPNP PTLAEIQARL AYVSSVDALE RAKMTPGCVY MRPPIDEYGT 1450
LEFGRFDEIV QVGYKYGLEF LQKLRDEGAL PVVEETEAKK ALRRTMAPRR 1500
ASI 1503
Length:1,503
Mass (Da):165,037
Last modified:July 24, 2007 - v2
Checksum:i3CC03B000E44724B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001233 Genomic DNA. Translation: EHA52211.1.
RefSeqiXP_003712018.1. XM_003711970.1.

Genome annotation databases

EnsemblFungiiMGG_06143T0; MGG_06143T0; MGG_06143.
GeneIDi2684255.
KEGGimgr:MGG_06143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001233 Genomic DNA. Translation: EHA52211.1 .
RefSeqi XP_003712018.1. XM_003711970.1.

3D structure databases

ProteinModelPortali A4QVZ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 148305.A4QVZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_06143T0 ; MGG_06143T0 ; MGG_06143 .
GeneIDi 2684255.
KEGGi mgr:MGG_06143.

Phylogenomic databases

eggNOGi COG0664.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiNTE1_MAGO7
AccessioniPrimary (citable) accession number: A4QVZ8
Secondary accession number(s): G4N5L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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