Reviewed, UniProtKB/Swiss-Prot A4QVH4 (CCPR_MAGGR)

Names and origin

Protein names

Recommended name:
    Cytochrome c peroxidase, mitochondrial
      Short name=CCP
    EC=1.11.1.5

Gene names

Name:	CCP1
ORF Names:	MGG_04545

Organism

Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) [Complete proteome]

Taxonomic identifier

148305 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Magnaporthales › Magnaporthaceae › Magnaporthe

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Subunit structure	Forms a one-to-one complex with cytochrome c By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cytochrome-c peroxidase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 40	40	Mitochondrion Potential
	Chain	41 – 362	322	Cytochrome c peroxidase, mitochondrial		PRO_0000363407
Regions
	Compositional bias	58 – 68	11	Poly-Ala
Sites
	Active site	121	1	Proton acceptor By similarity
	Active site	260	1	Tryptophan radical intermediate By similarity
	Metal binding	244	1	Iron (heme axial ligand) By similarity
	Site	117	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4QVH4-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 3E51FC022B61220A	FASTA	362	39,861
	10 20 30 40 50 60 MASASRQILR AASRASTRTA FAPAASRGLA ARTIAGRRFY SSSSEPAKAS SSNLGWIAGA 70 80 90 100 110 120 LAAAAAGAGY WYTQNGGAAT LTKPEFKDYQ TVYNDIASRL EENPDYDDGS YGPVLVRLAW 130 140 150 160 170 180 HASGTYDKET GTGGSNGATM RFSPEGGHGA NAGLKAARDF LEPIKAKYPW ITYSDLWILG 190 200 210 220 230 240 GVCAIQEMLG PKIPYRPGRS DKDAAACTPD GRLPDAAQRQ DHVRNIFYRM GFNDQEIVAL 250 260 270 280 290 300 AGAHALGRCH TDRSGFDGPW TFSPTVLTND YFKLLLNEKW EYKKWDGPKQ YVDSKTKSLM 310 320 330 340 350 360 MLPADMCLIE DKKFKEWTKK YADDNDLFFK DFSAAVLKLF ELGVPFAEGT ENQRWIFKPT SE

References

[1]

"The genome sequence of the rice blast fungus Magnaporthe grisea." Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., Soanes D.M. , Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W. Nature 434:980-986(2005) [PubMed: 15846337] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 70-15 / FGSC 8958.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH476822 Genomic DNA. Translation: EDJ96036.1.
RefSeq	XP_362100.2.
UniGene	Mgr.14694
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2677767.
KEGG	mgr:MGG_04545.
NMPDR	fig|242507.1.peg.3840.
Phylogenomic databases
OMA	HALGKTH.
Family and domain databases
InterPro	IPR002207. Asc_perxdse. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR_MAGGR

Accession

Primary (citable) accession number: A4QVH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 15, 2007
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)