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Protein

Mannitol 2-dehydrogenase

Gene

MGCH7_ch7g1113

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 4612NADBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol 2-dehydrogenase (EC:1.1.1.67)
Short name:
M2DH
Short name:
MDH
Gene namesi
ORF Names:MGCH7_ch7g1113, MGG_10334
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058 Componenti: Chromosome 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371545Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi148305.A4QQN1.

Structurei

3D structure databases

ProteinModelPortaliA4QQN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0246.
InParanoidiA4QQN1.
KOiK00045.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

A4QQN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFKLSTKHL ADIGAQTEKS IRIPSYDRND VKEGIVHVGV GGFHRAHLAV
60 70 80 90 100
YVDKLMQSHG VRDYAICGVG LQPADASMRD VLASQDHMYT VIERSAAGST
110 120 130 140 150
AHVVGSIRNF LFAPDDREAV IAKMAHPDTH IVSLTITESG YYYNENTHEL
160 170 180 190 200
QSEHPDIQHD LDPANAAKPK TTFGFLYAAM VRRREQGLKP FTVLSCDNML
210 220 230 240 250
KNGSITRNML QSFAKLKDPS MADWIAQYGG FPNAMVDRIT PRTSDPDIKE
260 270 280 290 300
LADKFKIDDA WPVVTEPFMQ WVVEDKFADG RPPFDLVGVQ VVKDVKDVEQ
310 320 330 340 350
FEKHKLRLLN ASHSAMGYPG QLAGFKYVHE VMEHPLYRKF IWQMMQEEVK
360 370 380 390 400
PLLPEIPGVD IDAYCNTLME RFSNPTIMDQ LPRIALNSSG KMPQFVMPSI
410 420 430 440 450
AEAIWVTGPF RRLVFVAACW FRYVLGVDDK GNKFEVDDPM REELQSKAQA
460 470 480 490 500
GGTKPHEILS IKSLFGDDLR GDERFLKEVT QAMEDIARDG VMATMPKFVN

DA
Length:502
Mass (Da):56,499
Last modified:May 15, 2007 - v1
Checksum:iF1D96C12DBDB7858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000230 Genomic DNA. Translation: EAQ71706.1.
CM001237 Genomic DNA. Translation: EHA45740.1.
RefSeqiXP_003720483.1. XM_003720435.1.

Genome annotation databases

EnsemblFungiiMGG_10334T0; MGG_10334T0; MGG_10334.
GeneIDi2681909.
KEGGimgr:MGG_10334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000230 Genomic DNA. Translation: EAQ71706.1.
CM001237 Genomic DNA. Translation: EHA45740.1.
RefSeqiXP_003720483.1. XM_003720435.1.

3D structure databases

ProteinModelPortaliA4QQN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi148305.A4QQN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiMGG_10334T0; MGG_10334T0; MGG_10334.
GeneIDi2681909.
KEGGimgr:MGG_10334.

Phylogenomic databases

eggNOGiCOG0246.
InParanoidiA4QQN1.
KOiK00045.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The sequence of Magnaporthe grisea chromosome 7."
    Thon M.R., Pan H., Diener A., Papalas J., Taro A., Mitchell T.K., Dean R.A.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiM2DH_MAGO7
AccessioniPrimary (citable) accession number: A4QQN1
Secondary accession number(s): G4NJS3, Q2KEC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 15, 2007
Last modified: May 27, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.