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A4QQN1

- M2DH_MAGO7

UniProt

A4QQN1 - M2DH_MAGO7

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Protein

Mannitol 2-dehydrogenase

Gene
MGCH7_ch7g1113, MGG_10334
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 4612NAD By similarityAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol 2-dehydrogenase (EC:1.1.1.67)
Short name:
M2DH
Short name:
MDH
Gene namesi
ORF Names:MGCH7_ch7g1113, MGG_10334
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371545Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi148305.A4QQN1.

Structurei

3D structure databases

ProteinModelPortaliA4QQN1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0246.
KOiK00045.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

A4QQN1-1 [UniParc]FASTAAdd to Basket

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MAFKLSTKHL ADIGAQTEKS IRIPSYDRND VKEGIVHVGV GGFHRAHLAV    50
YVDKLMQSHG VRDYAICGVG LQPADASMRD VLASQDHMYT VIERSAAGST 100
AHVVGSIRNF LFAPDDREAV IAKMAHPDTH IVSLTITESG YYYNENTHEL 150
QSEHPDIQHD LDPANAAKPK TTFGFLYAAM VRRREQGLKP FTVLSCDNML 200
KNGSITRNML QSFAKLKDPS MADWIAQYGG FPNAMVDRIT PRTSDPDIKE 250
LADKFKIDDA WPVVTEPFMQ WVVEDKFADG RPPFDLVGVQ VVKDVKDVEQ 300
FEKHKLRLLN ASHSAMGYPG QLAGFKYVHE VMEHPLYRKF IWQMMQEEVK 350
PLLPEIPGVD IDAYCNTLME RFSNPTIMDQ LPRIALNSSG KMPQFVMPSI 400
AEAIWVTGPF RRLVFVAACW FRYVLGVDDK GNKFEVDDPM REELQSKAQA 450
GGTKPHEILS IKSLFGDDLR GDERFLKEVT QAMEDIARDG VMATMPKFVN 500
DA 502
Length:502
Mass (Da):56,499
Last modified:May 15, 2007 - v1
Checksum:iF1D96C12DBDB7858
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000230 Genomic DNA. Translation: EAQ71706.1.
CM001237 Genomic DNA. Translation: EHA45740.1.
RefSeqiXP_003720483.1. XM_003720435.1.

Genome annotation databases

EnsemblFungiiMGG_10334T0; MGG_10334T0; MGG_10334.
GeneIDi2681909.
KEGGimgr:MGG_10334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000230 Genomic DNA. Translation: EAQ71706.1 .
CM001237 Genomic DNA. Translation: EHA45740.1 .
RefSeqi XP_003720483.1. XM_003720435.1.

3D structure databases

ProteinModelPortali A4QQN1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 148305.A4QQN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_10334T0 ; MGG_10334T0 ; MGG_10334 .
GeneIDi 2681909.
KEGGi mgr:MGG_10334.

Phylogenomic databases

eggNOGi COG0246.
KOi K00045.
OrthoDBi EOG7PCJRT.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view ]
PRINTSi PR00084. MTLDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The sequence of Magnaporthe grisea chromosome 7."
    Thon M.R., Pan H., Diener A., Papalas J., Taro A., Mitchell T.K., Dean R.A.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiM2DH_MAGO7
AccessioniPrimary (citable) accession number: A4QQN1
Secondary accession number(s): G4NJS3, Q2KEC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 15, 2007
Last modified: November 13, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi