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A4QQN1

- M2DH_MAGO7

UniProt

A4QQN1 - M2DH_MAGO7

Protein

Mannitol 2-dehydrogenase

Gene

MGCH7_ch7g1113

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

    Catalytic activityi

    D-mannitol + NAD+ = D-fructose + NADH.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi35 – 4612NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannitol 2-dehydrogenase (EC:1.1.1.67)
    Short name:
    M2DH
    Short name:
    MDH
    Gene namesi
    ORF Names:MGCH7_ch7g1113, MGG_10334
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 7

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371545Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi148305.A4QQN1.

    Structurei

    3D structure databases

    ProteinModelPortaliA4QQN1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannitol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0246.
    KOiK00045.
    OrthoDBiEOG7PCJRT.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4QQN1-1 [UniParc]FASTAAdd to Basket

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    MAFKLSTKHL ADIGAQTEKS IRIPSYDRND VKEGIVHVGV GGFHRAHLAV    50
    YVDKLMQSHG VRDYAICGVG LQPADASMRD VLASQDHMYT VIERSAAGST 100
    AHVVGSIRNF LFAPDDREAV IAKMAHPDTH IVSLTITESG YYYNENTHEL 150
    QSEHPDIQHD LDPANAAKPK TTFGFLYAAM VRRREQGLKP FTVLSCDNML 200
    KNGSITRNML QSFAKLKDPS MADWIAQYGG FPNAMVDRIT PRTSDPDIKE 250
    LADKFKIDDA WPVVTEPFMQ WVVEDKFADG RPPFDLVGVQ VVKDVKDVEQ 300
    FEKHKLRLLN ASHSAMGYPG QLAGFKYVHE VMEHPLYRKF IWQMMQEEVK 350
    PLLPEIPGVD IDAYCNTLME RFSNPTIMDQ LPRIALNSSG KMPQFVMPSI 400
    AEAIWVTGPF RRLVFVAACW FRYVLGVDDK GNKFEVDDPM REELQSKAQA 450
    GGTKPHEILS IKSLFGDDLR GDERFLKEVT QAMEDIARDG VMATMPKFVN 500
    DA 502
    Length:502
    Mass (Da):56,499
    Last modified:May 15, 2007 - v1
    Checksum:iF1D96C12DBDB7858
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000230 Genomic DNA. Translation: EAQ71706.1.
    CM001237 Genomic DNA. Translation: EHA45740.1.
    RefSeqiXP_003720483.1. XM_003720435.1.

    Genome annotation databases

    EnsemblFungiiMGG_10334T0; MGG_10334T0; MGG_10334.
    GeneIDi2681909.
    KEGGimgr:MGG_10334.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000230 Genomic DNA. Translation: EAQ71706.1 .
    CM001237 Genomic DNA. Translation: EHA45740.1 .
    RefSeqi XP_003720483.1. XM_003720435.1.

    3D structure databases

    ProteinModelPortali A4QQN1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 148305.A4QQN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_10334T0 ; MGG_10334T0 ; MGG_10334 .
    GeneIDi 2681909.
    KEGGi mgr:MGG_10334.

    Phylogenomic databases

    eggNOGi COG0246.
    KOi K00045.
    OrthoDBi EOG7PCJRT.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of Magnaporthe grisea chromosome 7."
      Thon M.R., Pan H., Diener A., Papalas J., Taro A., Mitchell T.K., Dean R.A.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

    Entry informationi

    Entry nameiM2DH_MAGO7
    AccessioniPrimary (citable) accession number: A4QQN1
    Secondary accession number(s): G4NJS3, Q2KEC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3