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A4QQN1 (M2DH_MAGO7) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol 2-dehydrogenase

Short name=M2DH
Short name=MDH
EC=1.1.1.67
Gene names
ORF Names:MGCH7_ch7g1113, MGG_10334
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome]
Taxonomic identifier242507 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol + NAD+ = D-fructose + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Mannitol 2-dehydrogenase
PRO_0000371545

Regions

Nucleotide binding35 – 4612NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QQN1 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: F1D96C12DBDB7858

FASTA50256,499
        10         20         30         40         50         60 
MAFKLSTKHL ADIGAQTEKS IRIPSYDRND VKEGIVHVGV GGFHRAHLAV YVDKLMQSHG 

        70         80         90        100        110        120 
VRDYAICGVG LQPADASMRD VLASQDHMYT VIERSAAGST AHVVGSIRNF LFAPDDREAV 

       130        140        150        160        170        180 
IAKMAHPDTH IVSLTITESG YYYNENTHEL QSEHPDIQHD LDPANAAKPK TTFGFLYAAM 

       190        200        210        220        230        240 
VRRREQGLKP FTVLSCDNML KNGSITRNML QSFAKLKDPS MADWIAQYGG FPNAMVDRIT 

       250        260        270        280        290        300 
PRTSDPDIKE LADKFKIDDA WPVVTEPFMQ WVVEDKFADG RPPFDLVGVQ VVKDVKDVEQ 

       310        320        330        340        350        360 
FEKHKLRLLN ASHSAMGYPG QLAGFKYVHE VMEHPLYRKF IWQMMQEEVK PLLPEIPGVD 

       370        380        390        400        410        420 
IDAYCNTLME RFSNPTIMDQ LPRIALNSSG KMPQFVMPSI AEAIWVTGPF RRLVFVAACW 

       430        440        450        460        470        480 
FRYVLGVDDK GNKFEVDDPM REELQSKAQA GGTKPHEILS IKSLFGDDLR GDERFLKEVT 

       490        500 
QAMEDIARDG VMATMPKFVN DA 

« Hide

References

[1]"The sequence of Magnaporthe grisea chromosome 7."
Thon M.R., Pan H., Diener A., Papalas J., Taro A., Mitchell T.K., Dean R.A.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.
[2]"The genome sequence of the rice blast fungus Magnaporthe grisea."
Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., Soanes D.M. expand/collapse author list , Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.
Nature 434:980-986(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000230 Genomic DNA. Translation: EAQ71706.1.
CM001237 Genomic DNA. Translation: EHA45740.1.
RefSeqXP_003720483.1. XM_003720435.1.

3D structure databases

ProteinModelPortalA4QQN1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING148305.A4QQN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiMGG_10334T0; MGG_10334T0; MGG_10334.
GeneID2681909.
KEGGmgr:MGG_10334.

Phylogenomic databases

eggNOGCOG0246.
KOK00045.
OrthoDBEOG7PCJRT.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameM2DH_MAGO7
AccessionPrimary (citable) accession number: A4QQN1
Secondary accession number(s): G4NJS3, Q2KEC3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 15, 2007
Last modified: November 13, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families