Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative phosphatidylinositol 4-kinase alpha-like protein P2

Gene

PI4KAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Enzyme and pathway databases

BioCyciZFISH:G66-31475-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphatidylinositol 4-kinase alpha-like protein P2
Gene namesi
Name:PI4KAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:33577. PI4KAP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219631 – 592Putative phosphatidylinositol 4-kinase alpha-like protein P2Add BLAST592

Proteomic databases

MaxQBiA4QPH2.
PaxDbiA4QPH2.
PRIDEiA4QPH2.

PTM databases

iPTMnetiA4QPH2.
PhosphoSitePlusiA4QPH2.

Interactioni

Protein-protein interaction databases

IntActiA4QPH2. 1 interactor.
MINTiMINT-1475709.
STRINGi9606.ENSP00000458238.

Structurei

3D structure databases

ProteinModelPortaliA4QPH2.
SMRiA4QPH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini312 – 592PI3K/PI4KPROSITE-ProRule annotationAdd BLAST281

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 318Pleckstrin homology (PH) domain conferring phosphoinositide binding specificityBy similarityAdd BLAST139

Sequence similaritiesi

Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0902. Eukaryota.
COG5032. LUCA.
HOVERGENiHBG103255.
InParanoidiA4QPH2.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 3 hits.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4QPH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVEQKFGLF SAEIKEADPL AASEASQPKP CPPEVTPHYI WIDFLVQRFE
60 70 80 90 100
IAKYCSSDQV EIFSSLLQRS MSLNIGRAKG SMNRHVAAIG PRFKLLTLGL
110 120 130 140 150
SLLHADVVPN ATIRNVLREK IYSTAFDYFS CPPKFPTQGE KRLREDISIM
160 170 180 190 200
IKFWTAMFSD KKYLTASQLV PPADIGDLLE QLVEENTGSL SGPAKDFYQR
210 220 230 240 250
GFDFFNKITN VSAVIKPYPK GDERKKACLS ALSEVTVQPG CSLPSNPEAI
260 270 280 290 300
VLDVDYKSGT PMQSAAKAPY LAKFKVKRCG VSELEKEGLR CRSDSEDECS
310 320 330 340 350
TQEADGQKIS WQAAIFKLGD DCRQKSYWGA RMPTDRILRL PASQDMLALQ
360 370 380 390 400
IIDLFKNIFQ LVGLDLFVFP YRVVATAPGC GVIECIPDCT SRDQLGRQTD
410 420 430 440 450
FGMYDYFTRQ YGDESTLAFQ QARYNFIRSM AAYSLLLFLL QIKDRHNGNI
460 470 480 490 500
MLDKKGHIIH IDFGFMFESS PGGNLGWEPD IKLTDEMVMI MGGKMEATPF
510 520 530 540 550
KWFMEMCVQA TWLCGEPGPY MDVVVSLVTI MLDTGLPCFR GQTIKLLKHR
560 570 580 590
FSPNMTEREA ANFIMKVIQS CFLSNRSRTY NMIQYYQNDI PY
Length:592
Mass (Da):66,944
Last modified:April 29, 2015 - v3
Checksum:i49C0ED1C2575676D
GO
Isoform 2 (identifier: A4QPH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-344: Missing.
     422-459: ARYNFIRSMA...IMLDKKGHII → VARVATGRGK...CSPQSSFVKG
     460-592: Missing.

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):48,715
Checksum:iB69650A4FB08D377
GO
Isoform 3 (identifier: A4QPH2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-344: Missing.
     516-521: EPGPYM → TGLAPT
     522-592: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):56,178
Checksum:iA42AE47CDA9DE8A0
GO

Sequence cautioni

The sequence AAI39842 differs from that shown. Contaminating sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201G → E in CAG30264 (PubMed:15461802).Curated1
Sequence conflicti201G → E in BAC86726 (PubMed:14702039).Curated1
Sequence conflicti201G → E in AAI39842 (PubMed:15489334).Curated1
Sequence conflicti201G → E in BC020225 (PubMed:15489334).Curated1
Sequence conflicti214V → I in CAG30264 (PubMed:15461802).Curated1
Sequence conflicti214V → I in BAC86726 (PubMed:14702039).Curated1
Sequence conflicti214V → I in AAI39842 (PubMed:15489334).Curated1
Sequence conflicti214V → I in BC020225 (PubMed:15489334).Curated1
Sequence conflicti332M → T in CAG30264 (PubMed:15461802).Curated1
Sequence conflicti332M → T in AAI39842 (PubMed:15489334).Curated1
Sequence conflicti423R → C in CAG30264 (PubMed:15461802).Curated1
Sequence conflicti423R → C in AAI39842 (PubMed:15489334).Curated1
Sequence conflicti546L → F in CAG30264 (PubMed:15461802).Curated1
Sequence conflicti546L → F in AAI39842 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039391223E → Q.Corresponds to variant rs2930770dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031848325 – 344Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_031849422 – 459ARYNF…KGHII → VARVATGRGKSCVLHPTPAT HTQPLPTPCSPQSSFVKG in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_031850460 – 592Missing in isoform 2. 1 PublicationAdd BLAST133
Alternative sequenceiVSP_057629516 – 521EPGPYM → TGLAPT in isoform 3. Curated6
Alternative sequenceiVSP_057630522 – 592Missing in isoform 3. CuratedAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456378 mRNA. Translation: CAG30264.1.
AK126860 mRNA. Translation: BAC86726.1.
AP000557 Genomic DNA. No translation available.
BC020225 mRNA. No translation available.
BC139841 mRNA. Translation: AAI39842.2. Sequence problems.
UniGeneiHs.448225.
Hs.592456.
Hs.743559.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456378 mRNA. Translation: CAG30264.1.
AK126860 mRNA. Translation: BAC86726.1.
AP000557 Genomic DNA. No translation available.
BC020225 mRNA. No translation available.
BC139841 mRNA. Translation: AAI39842.2. Sequence problems.
UniGeneiHs.448225.
Hs.592456.
Hs.743559.

3D structure databases

ProteinModelPortaliA4QPH2.
SMRiA4QPH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA4QPH2. 1 interactor.
MINTiMINT-1475709.
STRINGi9606.ENSP00000458238.

PTM databases

iPTMnetiA4QPH2.
PhosphoSitePlusiA4QPH2.

Proteomic databases

MaxQBiA4QPH2.
PaxDbiA4QPH2.
PRIDEiA4QPH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPI4KAP2.
HGNCiHGNC:33577. PI4KAP2.
neXtProtiNX_A4QPH2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0902. Eukaryota.
COG5032. LUCA.
HOVERGENiHBG103255.
InParanoidiA4QPH2.

Enzyme and pathway databases

BioCyciZFISH:G66-31475-MONOMER.

Miscellaneous databases

ChiTaRSiPI4KAP2. human.
PROiA4QPH2.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 3 hits.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI4P2_HUMAN
AccessioniPrimary (citable) accession number: A4QPH2
Secondary accession number(s): Q6ICJ0, Q6ZT68, Q8WUK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 29, 2015
Last modified: November 2, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.