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Protein

Putative phosphatidylinositol 4-kinase alpha-like protein P2

Gene

PI4KAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphatidylinositol 4-kinase alpha-like protein P2
Gene namesi
Name:PI4KAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:33577. PI4KAP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592Putative phosphatidylinositol 4-kinase alpha-like protein P2PRO_0000321963Add
BLAST

Proteomic databases

EPDiA4QPH2.
MaxQBiA4QPH2.
PaxDbiA4QPH2.
PRIDEiA4QPH2.

PTM databases

iPTMnetiA4QPH2.
PhosphoSiteiA4QPH2.

Interactioni

Protein-protein interaction databases

IntActiA4QPH2. 1 interaction.
MINTiMINT-1475709.
STRINGi9606.ENSP00000458238.

Structurei

3D structure databases

ProteinModelPortaliA4QPH2.
SMRiA4QPH2. Positions 178-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini312 – 592281PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 318139Pleckstrin homology (PH) domain conferring phosphoinositide binding specificityBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0902. Eukaryota.
COG5032. LUCA.
HOVERGENiHBG103255.
InParanoidiA4QPH2.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 3 hits.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4QPH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVEQKFGLF SAEIKEADPL AASEASQPKP CPPEVTPHYI WIDFLVQRFE
60 70 80 90 100
IAKYCSSDQV EIFSSLLQRS MSLNIGRAKG SMNRHVAAIG PRFKLLTLGL
110 120 130 140 150
SLLHADVVPN ATIRNVLREK IYSTAFDYFS CPPKFPTQGE KRLREDISIM
160 170 180 190 200
IKFWTAMFSD KKYLTASQLV PPADIGDLLE QLVEENTGSL SGPAKDFYQR
210 220 230 240 250
GFDFFNKITN VSAVIKPYPK GDERKKACLS ALSEVTVQPG CSLPSNPEAI
260 270 280 290 300
VLDVDYKSGT PMQSAAKAPY LAKFKVKRCG VSELEKEGLR CRSDSEDECS
310 320 330 340 350
TQEADGQKIS WQAAIFKLGD DCRQKSYWGA RMPTDRILRL PASQDMLALQ
360 370 380 390 400
IIDLFKNIFQ LVGLDLFVFP YRVVATAPGC GVIECIPDCT SRDQLGRQTD
410 420 430 440 450
FGMYDYFTRQ YGDESTLAFQ QARYNFIRSM AAYSLLLFLL QIKDRHNGNI
460 470 480 490 500
MLDKKGHIIH IDFGFMFESS PGGNLGWEPD IKLTDEMVMI MGGKMEATPF
510 520 530 540 550
KWFMEMCVQA TWLCGEPGPY MDVVVSLVTI MLDTGLPCFR GQTIKLLKHR
560 570 580 590
FSPNMTEREA ANFIMKVIQS CFLSNRSRTY NMIQYYQNDI PY
Length:592
Mass (Da):66,944
Last modified:April 29, 2015 - v3
Checksum:i49C0ED1C2575676D
GO
Isoform 2 (identifier: A4QPH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-344: Missing.
     422-459: ARYNFIRSMA...IMLDKKGHII → VARVATGRGK...CSPQSSFVKG
     460-592: Missing.

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):48,715
Checksum:iB69650A4FB08D377
GO
Isoform 3 (identifier: A4QPH2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-344: Missing.
     516-521: EPGPYM → TGLAPT
     522-592: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):56,178
Checksum:iA42AE47CDA9DE8A0
GO

Sequence cautioni

The sequence AAI39842.2 differs from that shown.Contaminating sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011G → E in CAG30264 (PubMed:15461802).Curated
Sequence conflicti201 – 2011G → E in BAC86726 (PubMed:14702039).Curated
Sequence conflicti201 – 2011G → E in AAI39842 (PubMed:15489334).Curated
Sequence conflicti201 – 2011G → E in BC020225 (PubMed:15489334).Curated
Sequence conflicti214 – 2141V → I in CAG30264 (PubMed:15461802).Curated
Sequence conflicti214 – 2141V → I in BAC86726 (PubMed:14702039).Curated
Sequence conflicti214 – 2141V → I in AAI39842 (PubMed:15489334).Curated
Sequence conflicti214 – 2141V → I in BC020225 (PubMed:15489334).Curated
Sequence conflicti332 – 3321M → T in CAG30264 (PubMed:15461802).Curated
Sequence conflicti332 – 3321M → T in AAI39842 (PubMed:15489334).Curated
Sequence conflicti423 – 4231R → C in CAG30264 (PubMed:15461802).Curated
Sequence conflicti423 – 4231R → C in AAI39842 (PubMed:15489334).Curated
Sequence conflicti546 – 5461L → F in CAG30264 (PubMed:15461802).Curated
Sequence conflicti546 – 5461L → F in AAI39842 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti223 – 2231E → Q.
Corresponds to variant rs2930770 [ dbSNP | Ensembl ].
VAR_039391

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 34420Missing in isoform 2 and isoform 3. 2 PublicationsVSP_031848Add
BLAST
Alternative sequencei422 – 45938ARYNF…KGHII → VARVATGRGKSCVLHPTPAT HTQPLPTPCSPQSSFVKG in isoform 2. 1 PublicationVSP_031849Add
BLAST
Alternative sequencei460 – 592133Missing in isoform 2. 1 PublicationVSP_031850Add
BLAST
Alternative sequencei516 – 5216EPGPYM → TGLAPT in isoform 3. CuratedVSP_057629
Alternative sequencei522 – 59271Missing in isoform 3. CuratedVSP_057630Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456378 mRNA. Translation: CAG30264.1.
AK126860 mRNA. Translation: BAC86726.1.
AP000557 Genomic DNA. No translation available.
BC020225 mRNA. No translation available.
BC139841 mRNA. Translation: AAI39842.2. Sequence problems.
UniGeneiHs.448225.
Hs.592456.
Hs.743559.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456378 mRNA. Translation: CAG30264.1.
AK126860 mRNA. Translation: BAC86726.1.
AP000557 Genomic DNA. No translation available.
BC020225 mRNA. No translation available.
BC139841 mRNA. Translation: AAI39842.2. Sequence problems.
UniGeneiHs.448225.
Hs.592456.
Hs.743559.

3D structure databases

ProteinModelPortaliA4QPH2.
SMRiA4QPH2. Positions 178-574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA4QPH2. 1 interaction.
MINTiMINT-1475709.
STRINGi9606.ENSP00000458238.

PTM databases

iPTMnetiA4QPH2.
PhosphoSiteiA4QPH2.

Proteomic databases

EPDiA4QPH2.
MaxQBiA4QPH2.
PaxDbiA4QPH2.
PRIDEiA4QPH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPI4KAP2.
HGNCiHGNC:33577. PI4KAP2.
neXtProtiNX_A4QPH2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0902. Eukaryota.
COG5032. LUCA.
HOVERGENiHBG103255.
InParanoidiA4QPH2.

Miscellaneous databases

ChiTaRSiPI4KAP2. human.
PROiA4QPH2.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 3 hits.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: B-cell.

Entry informationi

Entry nameiPI4P2_HUMAN
AccessioniPrimary (citable) accession number: A4QPH2
Secondary accession number(s): Q6ICJ0, Q6ZT68, Q8WUK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 29, 2015
Last modified: April 13, 2016
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.