Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Pms2 protein

Gene

Pms2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATPase activity Source: GO_Central
  2. ATP binding Source: InterPro
  3. DNA binding Source: MGI
  4. single base insertion or deletion binding Source: MGI
  5. single-stranded DNA binding Source: GO_Central

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: MGI
  2. DNA repair Source: MGI
  3. meiotic nuclear division Source: MGI
  4. mismatch repair Source: MGI
  5. response to drug Source: Ensembl
  6. somatic hypermutation of immunoglobulin genes Source: MGI
  7. somatic recombination of immunoglobulin gene segments Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_240368. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
REACT_246095. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).

Names & Taxonomyi

Protein namesi
Submitted name:
Pms2 proteinImported
Gene namesi
Name:Pms2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:104288. Pms2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. microtubule cytoskeleton Source: MGI
  3. MutLalpha complex Source: MGI
  4. nucleoplasm Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiA4QPD7.
ExpressionAtlasiA4QPD7. baseline and differential.
GenevestigatoriA4QPD7.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000165474.

Family and domain databases

InterProiIPR014790. MutL_C.
IPR028831. Pms1/Pms2/PMS2L.
[Graphical view]
PANTHERiPTHR10073:SF9. PTHR10073:SF9. 1 hit.
PfamiPF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM00853. MutL_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QPD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAEMEILGQ FNLGFIVTKL KEDLFLVDQH AADEKYNFEM LQQHTVLQAQ
60 70 80 90 100
RLITPQTLNL TAVNEAVLIE NLEIFRKNGF DFVIDEDAPV TERAKLISLP
110 120 130 140 150
TSKNWTFGPQ DIDELIFMLS DSPGVMCRPS RVRQMFASRA CRKSVMIGTA
160 170 180 190
LNASEMKKLI THMGEMDHPW NCPHGRPTMR HVANLDVISQ N
Length:191
Mass (Da):21,792
Last modified:May 15, 2007 - v1
Checksum:iBCA4971E53EDAEE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139774 mRNA. Translation: AAI39775.1.
UniGeneiMm.2950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139774 mRNA. Translation: AAI39775.1.
UniGeneiMm.2950.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104288. Pms2.

Phylogenomic databases

HOGENOMiHOG000165474.

Enzyme and pathway databases

ReactomeiREACT_240368. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
REACT_246095. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).

Miscellaneous databases

ChiTaRSiPms2. mouse.
NextBioi35544799.
SOURCEiSearch...

Gene expression databases

BgeeiA4QPD7.
ExpressionAtlasiA4QPD7. baseline and differential.
GenevestigatoriA4QPD7.

Family and domain databases

InterProiIPR014790. MutL_C.
IPR028831. Pms1/Pms2/PMS2L.
[Graphical view]
PANTHERiPTHR10073:SF9. PTHR10073:SF9. 1 hit.
PfamiPF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM00853. MutL_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.

Entry informationi

Entry nameiA4QPD7_MOUSE
AccessioniPrimary (citable) accession number: A4QPD7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: March 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.