SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4QPB2

- LRP5L_HUMAN

UniProt

A4QPB2 - LRP5L_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Low-density lipoprotein receptor-related protein 5-like protein

Gene
LRP5L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Wnt-activated receptor activity Source: RefGenome
  2. Wnt-protein binding Source: RefGenome

GO - Biological processi

  1. canonical Wnt signaling pathway Source: RefGenome
  2. Wnt signaling pathway involved in dorsal/ventral axis specification Source: RefGenome
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 5-like protein
Short name:
LRP-5-like
Gene namesi
Name:LRP5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:25323. LRP5L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671533.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Low-density lipoprotein receptor-related protein 5-like proteinPRO_0000294474Add
BLAST

Proteomic databases

PaxDbiA4QPB2.
PRIDEiA4QPB2.

Expressioni

Gene expression databases

ArrayExpressiA4QPB2.
BgeeiA4QPB2.
CleanExiHS_LRP5L.
GenevestigatoriA4QPB2.

Organism-specific databases

HPAiHPA028717.

Interactioni

Protein-protein interaction databases

BioGridi124819. 2 interactions.
IntActiA4QPB2. 2 interactions.
MINTiMINT-8247433.
STRINGi9606.ENSP00000215872.

Structurei

3D structure databases

ProteinModelPortaliA4QPB2.
SMRiA4QPB2. Positions 1-246.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati3 – 4543LDL-receptor class B 1Add
BLAST
Repeati46 – 8843LDL-receptor class B 2Add
BLAST
Repeati89 – 13244LDL-receptor class B 3Add
BLAST
Repeati133 – 17543LDL-receptor class B 4Add
BLAST
Repeati176 – 21843LDL-receptor class B 5Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG121718.
HOGENOMiHOG000113388.
InParanoidiA4QPB2.
OMAiWIDWGEN.
OrthoDBiEOG7M0NQN.
PhylomeDBiA4QPB2.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 3 hits.
[Graphical view]
SMARTiSM00135. LY. 4 hits.
[Graphical view]
PROSITEiPS51120. LDLRB. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A4QPB2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEGHVYWTDD EVWAIRRAYL DGSGAQTLIN TKINDPDDIA VNWVARSLYW    50
THTGTEHIEV TCLNSTSHKI LVSEDMDEPR AIALHPEMGL TYWIDWGENP 100
EIKRANLDRQ ELRVLVNASL GWPNGLALDL QEGKLYWGDA KTDKIEAISV 150
DETKRQTLLK DKLPHIFRFT LLGDFIYWTA WQHHSIKRVH KVKANRDVII 200
DQLPDLMGLK AVNVDKVVGT NPHADRNGGA ATCASSRPTQ PGLAAPSRAW 250
NC 252
Length:252
Mass (Da):28,483
Last modified:July 10, 2007 - v2
Checksum:i20ACE726A1FF7C5A
GO
Isoform 2 (identifier: A4QPB2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-224: TNPHA → PGTAE
     225-252: Missing.

Note: No experimental confirmation available.

Show »
Length:224
Mass (Da):25,620
Checksum:i5CFCFB99517D359A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611T → M.
Corresponds to variant rs17616994 [ dbSNP | Ensembl ].
VAR_033191

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei220 – 2245TNPHA → PGTAE in isoform 2. VSP_026667
Alternative sequencei225 – 25228Missing in isoform 2. VSP_026668Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL137651 mRNA. No translation available.
AL022324 Genomic DNA. Translation: CAQ06630.1.
AL022324 Genomic DNA. Translation: CAQ06631.1.
BC137460 mRNA. Translation: AAI37461.1.
BC137463 mRNA. Translation: AAI37464.1.
BC139736 mRNA. Translation: AAI39737.1.
CCDSiCCDS33626.1. [A4QPB2-1]
RefSeqiNP_001129244.1. NM_001135772.1. [A4QPB2-1]
NP_872298.1. NM_182492.2. [A4QPB2-1]
XP_006724435.1. XM_006724372.1. [A4QPB2-2]
UniGeneiHs.634058.

Genome annotation databases

EnsembliENST00000402785; ENSP00000384562; ENSG00000100068. [A4QPB2-1]
ENST00000402859; ENSP00000384291; ENSG00000100068. [A4QPB2-1]
ENST00000444995; ENSP00000407283; ENSG00000100068. [A4QPB2-2]
GeneIDi91355.
KEGGihsa:91355.
UCSCiuc003abs.3. human. [A4QPB2-1]
uc010guw.1. human. [A4QPB2-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL137651 mRNA. No translation available.
AL022324 Genomic DNA. Translation: CAQ06630.1 .
AL022324 Genomic DNA. Translation: CAQ06631.1 .
BC137460 mRNA. Translation: AAI37461.1 .
BC137463 mRNA. Translation: AAI37464.1 .
BC139736 mRNA. Translation: AAI39737.1 .
CCDSi CCDS33626.1. [A4QPB2-1 ]
RefSeqi NP_001129244.1. NM_001135772.1. [A4QPB2-1 ]
NP_872298.1. NM_182492.2. [A4QPB2-1 ]
XP_006724435.1. XM_006724372.1. [A4QPB2-2 ]
UniGenei Hs.634058.

3D structure databases

ProteinModelPortali A4QPB2.
SMRi A4QPB2. Positions 1-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124819. 2 interactions.
IntActi A4QPB2. 2 interactions.
MINTi MINT-8247433.
STRINGi 9606.ENSP00000215872.

Proteomic databases

PaxDbi A4QPB2.
PRIDEi A4QPB2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000402785 ; ENSP00000384562 ; ENSG00000100068 . [A4QPB2-1 ]
ENST00000402859 ; ENSP00000384291 ; ENSG00000100068 . [A4QPB2-1 ]
ENST00000444995 ; ENSP00000407283 ; ENSG00000100068 . [A4QPB2-2 ]
GeneIDi 91355.
KEGGi hsa:91355.
UCSCi uc003abs.3. human. [A4QPB2-1 ]
uc010guw.1. human. [A4QPB2-2 ]

Organism-specific databases

CTDi 91355.
GeneCardsi GC22M025747.
HGNCi HGNC:25323. LRP5L.
HPAi HPA028717.
neXtProti NX_A4QPB2.
PharmGKBi PA142671533.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG121718.
HOGENOMi HOG000113388.
InParanoidi A4QPB2.
OMAi WIDWGEN.
OrthoDBi EOG7M0NQN.
PhylomeDBi A4QPB2.

Miscellaneous databases

ChiTaRSi LRP5L. human.
GenomeRNAii 91355.
NextBioi 77199.
PROi A4QPB2.

Gene expression databases

ArrayExpressi A4QPB2.
Bgeei A4QPB2.
CleanExi HS_LRP5L.
Genevestigatori A4QPB2.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000033. LDLR_classB_rpt.
[Graphical view ]
Pfami PF00058. Ldl_recept_b. 3 hits.
[Graphical view ]
SMARTi SM00135. LY. 4 hits.
[Graphical view ]
PROSITEi PS51120. LDLRB. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiLRP5L_HUMAN
AccessioniPrimary (citable) accession number: A4QPB2
Secondary accession number(s): B0QYF3, B0QYF4, B2RPI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 9, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi