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Protein

Low-density lipoprotein receptor-related protein 5-like protein

Gene

LRP5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Wnt-activated receptor activity Source: GO_Central
  2. Wnt-protein binding Source: GO_Central

GO - Biological processi

  1. canonical Wnt signaling pathway Source: GO_Central
  2. Wnt signaling pathway involved in dorsal/ventral axis specification Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 5-like protein
Short name:
LRP-5-like
Gene namesi
Name:LRP5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:25323. LRP5L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671533.

Polymorphism and mutation databases

BioMutaiLRP5L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Low-density lipoprotein receptor-related protein 5-like proteinPRO_0000294474Add
BLAST

Proteomic databases

PaxDbiA4QPB2.
PRIDEiA4QPB2.

Expressioni

Gene expression databases

BgeeiA4QPB2.
CleanExiHS_LRP5L.
ExpressionAtlasiA4QPB2. baseline and differential.
GenevestigatoriA4QPB2.

Organism-specific databases

HPAiHPA028717.

Interactioni

Protein-protein interaction databases

BioGridi124819. 2 interactions.
IntActiA4QPB2. 2 interactions.
MINTiMINT-8247433.
STRINGi9606.ENSP00000215872.

Structurei

3D structure databases

ProteinModelPortaliA4QPB2.
SMRiA4QPB2. Positions 1-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati3 – 4543LDL-receptor class B 1Add
BLAST
Repeati46 – 8843LDL-receptor class B 2Add
BLAST
Repeati89 – 13244LDL-receptor class B 3Add
BLAST
Repeati133 – 17543LDL-receptor class B 4Add
BLAST
Repeati176 – 21843LDL-receptor class B 5Add
BLAST

Sequence similaritiesi

Contains 5 LDL-receptor class B repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG121718.
GeneTreeiENSGT00760000118968.
HOGENOMiHOG000113388.
InParanoidiA4QPB2.
OMAiWIDWGEN.
OrthoDBiEOG7M0NQN.
PhylomeDBiA4QPB2.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 3 hits.
[Graphical view]
SMARTiSM00135. LY. 4 hits.
[Graphical view]
PROSITEiPS51120. LDLRB. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4QPB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGHVYWTDD EVWAIRRAYL DGSGAQTLIN TKINDPDDIA VNWVARSLYW
60 70 80 90 100
THTGTEHIEV TCLNSTSHKI LVSEDMDEPR AIALHPEMGL TYWIDWGENP
110 120 130 140 150
EIKRANLDRQ ELRVLVNASL GWPNGLALDL QEGKLYWGDA KTDKIEAISV
160 170 180 190 200
DETKRQTLLK DKLPHIFRFT LLGDFIYWTA WQHHSIKRVH KVKANRDVII
210 220 230 240 250
DQLPDLMGLK AVNVDKVVGT NPHADRNGGA ATCASSRPTQ PGLAAPSRAW

NC
Length:252
Mass (Da):28,483
Last modified:July 10, 2007 - v2
Checksum:i20ACE726A1FF7C5A
GO
Isoform 2 (identifier: A4QPB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-224: TNPHA → PGTAE
     225-252: Missing.

Note: No experimental confirmation available.

Show »
Length:224
Mass (Da):25,620
Checksum:i5CFCFB99517D359A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611T → M.
Corresponds to variant rs17616994 [ dbSNP | Ensembl ].
VAR_033191

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei220 – 2245TNPHA → PGTAE in isoform 2. 1 PublicationVSP_026667
Alternative sequencei225 – 25228Missing in isoform 2. 1 PublicationVSP_026668Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137651 mRNA. No translation available.
AL022324 Genomic DNA. Translation: CAQ06630.1.
AL022324 Genomic DNA. Translation: CAQ06631.1.
BC137460 mRNA. Translation: AAI37461.1.
BC137463 mRNA. Translation: AAI37464.1.
BC139736 mRNA. Translation: AAI39737.1.
CCDSiCCDS33626.1. [A4QPB2-1]
RefSeqiNP_001129244.1. NM_001135772.1. [A4QPB2-1]
NP_872298.1. NM_182492.2. [A4QPB2-1]
XP_006724435.1. XM_006724372.2. [A4QPB2-2]
UniGeneiHs.634058.

Genome annotation databases

EnsembliENST00000402785; ENSP00000384562; ENSG00000100068. [A4QPB2-1]
ENST00000402859; ENSP00000384291; ENSG00000100068. [A4QPB2-1]
ENST00000444995; ENSP00000407283; ENSG00000100068. [A4QPB2-2]
ENST00000610821; ENSP00000482378; ENSG00000100068. [A4QPB2-1]
GeneIDi91355.
KEGGihsa:91355.
UCSCiuc003abs.3. human. [A4QPB2-1]
uc010guw.1. human. [A4QPB2-2]

Polymorphism and mutation databases

BioMutaiLRP5L.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137651 mRNA. No translation available.
AL022324 Genomic DNA. Translation: CAQ06630.1.
AL022324 Genomic DNA. Translation: CAQ06631.1.
BC137460 mRNA. Translation: AAI37461.1.
BC137463 mRNA. Translation: AAI37464.1.
BC139736 mRNA. Translation: AAI39737.1.
CCDSiCCDS33626.1. [A4QPB2-1]
RefSeqiNP_001129244.1. NM_001135772.1. [A4QPB2-1]
NP_872298.1. NM_182492.2. [A4QPB2-1]
XP_006724435.1. XM_006724372.2. [A4QPB2-2]
UniGeneiHs.634058.

3D structure databases

ProteinModelPortaliA4QPB2.
SMRiA4QPB2. Positions 1-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124819. 2 interactions.
IntActiA4QPB2. 2 interactions.
MINTiMINT-8247433.
STRINGi9606.ENSP00000215872.

Polymorphism and mutation databases

BioMutaiLRP5L.

Proteomic databases

PaxDbiA4QPB2.
PRIDEiA4QPB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402785; ENSP00000384562; ENSG00000100068. [A4QPB2-1]
ENST00000402859; ENSP00000384291; ENSG00000100068. [A4QPB2-1]
ENST00000444995; ENSP00000407283; ENSG00000100068. [A4QPB2-2]
ENST00000610821; ENSP00000482378; ENSG00000100068. [A4QPB2-1]
GeneIDi91355.
KEGGihsa:91355.
UCSCiuc003abs.3. human. [A4QPB2-1]
uc010guw.1. human. [A4QPB2-2]

Organism-specific databases

CTDi91355.
GeneCardsiGC22M025747.
HGNCiHGNC:25323. LRP5L.
HPAiHPA028717.
neXtProtiNX_A4QPB2.
PharmGKBiPA142671533.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG121718.
GeneTreeiENSGT00760000118968.
HOGENOMiHOG000113388.
InParanoidiA4QPB2.
OMAiWIDWGEN.
OrthoDBiEOG7M0NQN.
PhylomeDBiA4QPB2.

Miscellaneous databases

ChiTaRSiLRP5L. human.
GenomeRNAii91355.
NextBioi77199.
PROiA4QPB2.

Gene expression databases

BgeeiA4QPB2.
CleanExiHS_LRP5L.
ExpressionAtlasiA4QPB2. baseline and differential.
GenevestigatoriA4QPB2.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 3 hits.
[Graphical view]
SMARTiSM00135. LY. 4 hits.
[Graphical view]
PROSITEiPS51120. LDLRB. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiLRP5L_HUMAN
AccessioniPrimary (citable) accession number: A4QPB2
Secondary accession number(s): B0QYF3, B0QYF4, B2RPI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 29, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.