Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4QPB2 (LRP5L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low-density lipoprotein receptor-related protein 5-like protein

Short name=LRP-5-like
Gene names
Name:LRP5L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 5 LDL-receptor class B repeats.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A4QPB2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A4QPB2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     220-224: TNPHA → PGTAE
     225-252: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Low-density lipoprotein receptor-related protein 5-like protein
PRO_0000294474

Regions

Repeat3 – 4543LDL-receptor class B 1
Repeat46 – 8843LDL-receptor class B 2
Repeat89 – 13244LDL-receptor class B 3
Repeat133 – 17543LDL-receptor class B 4
Repeat176 – 21843LDL-receptor class B 5

Natural variations

Alternative sequence220 – 2245TNPHA → PGTAE in isoform 2.
VSP_026667
Alternative sequence225 – 25228Missing in isoform 2.
VSP_026668
Natural variant611T → M.
Corresponds to variant rs17616994 [ dbSNP | Ensembl ].
VAR_033191

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 20ACE726A1FF7C5A

FASTA25228,483
        10         20         30         40         50         60 
MEGHVYWTDD EVWAIRRAYL DGSGAQTLIN TKINDPDDIA VNWVARSLYW THTGTEHIEV 

        70         80         90        100        110        120 
TCLNSTSHKI LVSEDMDEPR AIALHPEMGL TYWIDWGENP EIKRANLDRQ ELRVLVNASL 

       130        140        150        160        170        180 
GWPNGLALDL QEGKLYWGDA KTDKIEAISV DETKRQTLLK DKLPHIFRFT LLGDFIYWTA 

       190        200        210        220        230        240 
WQHHSIKRVH KVKANRDVII DQLPDLMGLK AVNVDKVVGT NPHADRNGGA ATCASSRPTQ 

       250 
PGLAAPSRAW NC 

« Hide

Isoform 2 [UniParc].

Checksum: 5CFCFB99517D359A
Show »

FASTA22425,620

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL137651 mRNA. No translation available.
AL022324 Genomic DNA. Translation: CAQ06630.1.
AL022324 Genomic DNA. Translation: CAQ06631.1.
BC137460 mRNA. Translation: AAI37461.1.
BC137463 mRNA. Translation: AAI37464.1.
BC139736 mRNA. Translation: AAI39737.1.
RefSeqNP_001129244.1. NM_001135772.1.
NP_872298.1. NM_182492.2.
UniGeneHs.634058.

3D structure databases

ProteinModelPortalA4QPB2.
SMRA4QPB2. Positions 1-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124819. 2 interactions.
IntActA4QPB2. 2 interactions.
MINTMINT-8247433.
STRING9606.ENSP00000215872.

Proteomic databases

PaxDbA4QPB2.
PRIDEA4QPB2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000402785; ENSP00000384562; ENSG00000100068. [A4QPB2-1]
ENST00000402859; ENSP00000384291; ENSG00000100068. [A4QPB2-1]
ENST00000444995; ENSP00000407283; ENSG00000100068. [A4QPB2-2]
GeneID91355.
KEGGhsa:91355.
UCSCuc003abs.3. human. [A4QPB2-1]
uc010guw.1. human. [A4QPB2-2]

Organism-specific databases

CTD91355.
GeneCardsGC22M025747.
HGNCHGNC:25323. LRP5L.
HPAHPA028717.
neXtProtNX_A4QPB2.
PharmGKBPA142671533.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG121718.
HOGENOMHOG000113388.
InParanoidA4QPB2.
OMAWIDWGEN.
OrthoDBEOG7M0NQN.
PhylomeDBA4QPB2.

Gene expression databases

ArrayExpressA4QPB2.
BgeeA4QPB2.
CleanExHS_LRP5L.
GenevestigatorA4QPB2.

Family and domain databases

Gene3D2.120.10.30. 1 hit.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamPF00058. Ldl_recept_b. 3 hits.
[Graphical view]
SMARTSM00135. LY. 4 hits.
[Graphical view]
PROSITEPS51120. LDLRB. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLRP5L. human.
GenomeRNAi91355.
NextBio77199.
PROA4QPB2.

Entry information

Entry nameLRP5L_HUMAN
AccessionPrimary (citable) accession number: A4QPB2
Secondary accession number(s): B0QYF3, B0QYF4, B2RPI5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM