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A4QPB2

- LRP5L_HUMAN

UniProt

A4QPB2 - LRP5L_HUMAN

Protein

Low-density lipoprotein receptor-related protein 5-like protein

Gene

LRP5L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. Wnt-activated receptor activity Source: RefGenome
    2. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: RefGenome
    2. Wnt signaling pathway involved in dorsal/ventral axis specification Source: RefGenome

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low-density lipoprotein receptor-related protein 5-like protein
    Short name:
    LRP-5-like
    Gene namesi
    Name:LRP5L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:25323. LRP5L.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671533.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252Low-density lipoprotein receptor-related protein 5-like proteinPRO_0000294474Add
    BLAST

    Proteomic databases

    PaxDbiA4QPB2.
    PRIDEiA4QPB2.

    Expressioni

    Gene expression databases

    ArrayExpressiA4QPB2.
    BgeeiA4QPB2.
    CleanExiHS_LRP5L.
    GenevestigatoriA4QPB2.

    Organism-specific databases

    HPAiHPA028717.

    Interactioni

    Protein-protein interaction databases

    BioGridi124819. 2 interactions.
    IntActiA4QPB2. 2 interactions.
    MINTiMINT-8247433.
    STRINGi9606.ENSP00000215872.

    Structurei

    3D structure databases

    ProteinModelPortaliA4QPB2.
    SMRiA4QPB2. Positions 1-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati3 – 4543LDL-receptor class B 1Add
    BLAST
    Repeati46 – 8843LDL-receptor class B 2Add
    BLAST
    Repeati89 – 13244LDL-receptor class B 3Add
    BLAST
    Repeati133 – 17543LDL-receptor class B 4Add
    BLAST
    Repeati176 – 21843LDL-receptor class B 5Add
    BLAST

    Sequence similaritiesi

    Contains 5 LDL-receptor class B repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG121718.
    HOGENOMiHOG000113388.
    InParanoidiA4QPB2.
    OMAiWIDWGEN.
    OrthoDBiEOG7M0NQN.
    PhylomeDBiA4QPB2.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR000033. LDLR_classB_rpt.
    [Graphical view]
    PfamiPF00058. Ldl_recept_b. 3 hits.
    [Graphical view]
    SMARTiSM00135. LY. 4 hits.
    [Graphical view]
    PROSITEiPS51120. LDLRB. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A4QPB2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGHVYWTDD EVWAIRRAYL DGSGAQTLIN TKINDPDDIA VNWVARSLYW    50
    THTGTEHIEV TCLNSTSHKI LVSEDMDEPR AIALHPEMGL TYWIDWGENP 100
    EIKRANLDRQ ELRVLVNASL GWPNGLALDL QEGKLYWGDA KTDKIEAISV 150
    DETKRQTLLK DKLPHIFRFT LLGDFIYWTA WQHHSIKRVH KVKANRDVII 200
    DQLPDLMGLK AVNVDKVVGT NPHADRNGGA ATCASSRPTQ PGLAAPSRAW 250
    NC 252
    Length:252
    Mass (Da):28,483
    Last modified:July 10, 2007 - v2
    Checksum:i20ACE726A1FF7C5A
    GO
    Isoform 2 (identifier: A4QPB2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         220-224: TNPHA → PGTAE
         225-252: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:224
    Mass (Da):25,620
    Checksum:i5CFCFB99517D359A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611T → M.
    Corresponds to variant rs17616994 [ dbSNP | Ensembl ].
    VAR_033191

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei220 – 2245TNPHA → PGTAE in isoform 2. 1 PublicationVSP_026667
    Alternative sequencei225 – 25228Missing in isoform 2. 1 PublicationVSP_026668Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL137651 mRNA. No translation available.
    AL022324 Genomic DNA. Translation: CAQ06630.1.
    AL022324 Genomic DNA. Translation: CAQ06631.1.
    BC137460 mRNA. Translation: AAI37461.1.
    BC137463 mRNA. Translation: AAI37464.1.
    BC139736 mRNA. Translation: AAI39737.1.
    CCDSiCCDS33626.1. [A4QPB2-1]
    RefSeqiNP_001129244.1. NM_001135772.1. [A4QPB2-1]
    NP_872298.1. NM_182492.2. [A4QPB2-1]
    XP_006724435.1. XM_006724372.1. [A4QPB2-2]
    UniGeneiHs.634058.

    Genome annotation databases

    EnsembliENST00000402785; ENSP00000384562; ENSG00000100068. [A4QPB2-1]
    ENST00000402859; ENSP00000384291; ENSG00000100068. [A4QPB2-1]
    ENST00000444995; ENSP00000407283; ENSG00000100068. [A4QPB2-2]
    GeneIDi91355.
    KEGGihsa:91355.
    UCSCiuc003abs.3. human. [A4QPB2-1]
    uc010guw.1. human. [A4QPB2-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL137651 mRNA. No translation available.
    AL022324 Genomic DNA. Translation: CAQ06630.1 .
    AL022324 Genomic DNA. Translation: CAQ06631.1 .
    BC137460 mRNA. Translation: AAI37461.1 .
    BC137463 mRNA. Translation: AAI37464.1 .
    BC139736 mRNA. Translation: AAI39737.1 .
    CCDSi CCDS33626.1. [A4QPB2-1 ]
    RefSeqi NP_001129244.1. NM_001135772.1. [A4QPB2-1 ]
    NP_872298.1. NM_182492.2. [A4QPB2-1 ]
    XP_006724435.1. XM_006724372.1. [A4QPB2-2 ]
    UniGenei Hs.634058.

    3D structure databases

    ProteinModelPortali A4QPB2.
    SMRi A4QPB2. Positions 1-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124819. 2 interactions.
    IntActi A4QPB2. 2 interactions.
    MINTi MINT-8247433.
    STRINGi 9606.ENSP00000215872.

    Proteomic databases

    PaxDbi A4QPB2.
    PRIDEi A4QPB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000402785 ; ENSP00000384562 ; ENSG00000100068 . [A4QPB2-1 ]
    ENST00000402859 ; ENSP00000384291 ; ENSG00000100068 . [A4QPB2-1 ]
    ENST00000444995 ; ENSP00000407283 ; ENSG00000100068 . [A4QPB2-2 ]
    GeneIDi 91355.
    KEGGi hsa:91355.
    UCSCi uc003abs.3. human. [A4QPB2-1 ]
    uc010guw.1. human. [A4QPB2-2 ]

    Organism-specific databases

    CTDi 91355.
    GeneCardsi GC22M025747.
    HGNCi HGNC:25323. LRP5L.
    HPAi HPA028717.
    neXtProti NX_A4QPB2.
    PharmGKBi PA142671533.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG121718.
    HOGENOMi HOG000113388.
    InParanoidi A4QPB2.
    OMAi WIDWGEN.
    OrthoDBi EOG7M0NQN.
    PhylomeDBi A4QPB2.

    Miscellaneous databases

    ChiTaRSi LRP5L. human.
    GenomeRNAii 91355.
    NextBioi 77199.
    PROi A4QPB2.

    Gene expression databases

    ArrayExpressi A4QPB2.
    Bgeei A4QPB2.
    CleanExi HS_LRP5L.
    Genevestigatori A4QPB2.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR000033. LDLR_classB_rpt.
    [Graphical view ]
    Pfami PF00058. Ldl_recept_b. 3 hits.
    [Graphical view ]
    SMARTi SM00135. LY. 4 hits.
    [Graphical view ]
    PROSITEi PS51120. LDLRB. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiLRP5L_HUMAN
    AccessioniPrimary (citable) accession number: A4QPB2
    Secondary accession number(s): B0QYF3, B0QYF4, B2RPI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3