A4QNV1 (A4QNV1_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phosphofructokinase PIRNR PIRNR000533
EC=2.7.1.11 PIRNR PIRNR000533

Alternative name(s):
Phosphohexokinase PIRNR PIRNR000533

Gene names

Name:	pfkmb ZFIN ZDB-GENE-081114-1
Synonyms:	pfkm ZFIN ZDB-GENE-040912-135

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAI39533.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	776 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. PIRNR PIRNR000533
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. PIRNR PIRNR000533
Sequence similarities	Belongs to the phosphofructokinase family. Two domains subfamily. PIRNR PIRNR000533

Ontologies

Keywords
Biological process	Glycolysis PIRNR PIRNR000533
Ligand	ATP-binding PIRNR PIRNR000533 RuleBase RU004092 Nucleotide-binding
Molecular function	Kinase PIRNR PIRNR000533 RuleBase RU004092 Transferase
Gene Ontology (GO)
Biological_process	fructose 6-phosphate metabolic process Inferred from electronic annotation. Source: InterPro glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	6-phosphofructokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4QNV1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 92D93282047C995D	FASTA	776	84,166
	10 20 30 40 50 60 MQHSAPVDPT KMGVGRAIAV LTSGGDAQGM NAAVRATVRV GIYTGAKVYF VHEGYQGLVD 70 80 90 100 110 120 GGDNIRQATW ESVSMMLQLG GTVIGSARCQ DFRTKEGRAK AACNLVKLGI TNLCVIGGDG 130 140 150 160 170 180 SLTGANEFRN EWSELLQILQ KAGKITAEEA KCSSHLNIVG MVGSIDNDFC GTDMTIGTDS 190 200 210 220 230 240 ALHRIMEVVD AITTTAQSHQ RAFILEVMGR HCGYLALVTA LSCGADWVFI PEMPPDEGWE 250 260 270 280 290 300 DHLCRRLTYQ RSIGNRLNVI IVAEGALDRH GKPITCDIIK NLVTKKLGFD TRATILGHVQ 310 320 330 340 350 360 RGGTPSAFDR ILGSRMGVEA VMALLEATPD TPACVVSLSG NMAVRLPLME CVQVTKEVTK 370 380 390 400 410 420 AMAEGRFEEA IKLRGKSFEN NWNTYKLLAH VTAPDVKSNI NIAILNVGAP CAGMNAAVRS 430 440 450 460 470 480 AVRIGILQGH NMLAVHDGFE GLANGTIEPM AWGYVGGWTG KGGSILGTKR SLPANMIEEI 490 500 510 520 530 540 SLNIAKFNIH ALVIIGGFEA FVGGLELVTA REKYEELCIP LVVIPATVSN NVPGSDFSVG 550 560 570 580 590 600 ADTALNTITT TCDRIKQSAA GTKRRVFIIE TMGGYCGYLA TMAGLAAGAD AAYVFEDPFG 610 620 630 640 650 660 IHDLEANVEH LLEKMKTTVK RGLILRNEKC NANYTTDFLF NLYSEEGKGV FDCRKNVLGH 670 680 690 700 710 720 MQQGGTPTPF DRNFGTKMGA KAVLWLTDKL KECYRHGRIF ANTPDSACVL GMRKRAMLFQ 730 740 750 760 770 PLSDLKEDTD FEHRIPKTEW WLKLRPILKI LAKYKISLDT SETATMEHVI KKRGGV

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Whole body EMBL AAI39533.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC139532 mRNA. Translation: AAI39533.1.
IPI	IPI00798961.
RefSeq	NP_001082886.1. NM_001089417.1.
UniGene	Dr.41754.
3D structure databases
ProteinModelPortal	A4QNV1.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000079712.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	568001.
KEGG	dre:568001.
Organism-specific databases
CTD	568001.
ZFIN	ZDB-GENE-081114-1. pfkmb.
Phylogenomic databases
eggNOG	COG0205.
HOGENOM	HOG000200154.
HOVERGEN	HBG000976.
KO	K00850.
OrthoDB	EOG4RJG0W.
Enzyme and pathway databases
UniPathway	UPA00109; UER00182.
Family and domain databases
HAMAP	MF_00339. Phosphofructokinase.
InterPro	IPR009161. 6-phosphofructokinase_euk. IPR022953. Phosphofructokinase. IPR015912. Phosphofructokinase_CS. IPR000023. Phosphofructokinase_dom. [Graphical view]
Pfam	PF00365. PFK. 2 hits. [Graphical view]
PIRSF	PIRSF000533. ATP_PFK_euk. 1 hit.
PRINTS	PR00476. PHFRCTKINASE.
SUPFAM	SSF53784. Ppfruckinase. 2 hits.
TIGRFAMs	TIGR02478. 6PF1K_euk. 1 hit.
PROSITE	PS00433. PHOSPHOFRUCTOKINASE. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20888958.

Entry information

Entry name

A4QNV1_DANRE

Accession

Primary (citable) accession number: A4QNV1

Entry history

Integrated into UniProtKB/TrEMBL:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)