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A4QNR3

- BRF2_XENTR

UniProt

A4QNR3 - BRF2_XENTR

Protein

Transcription factor IIIB 50 kDa subunit

Gene

brf2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71ZincBy similarity
    Metal bindingi10 – 101ZincBy similarity
    Metal bindingi28 – 281ZincBy similarity
    Metal bindingi31 – 311ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri3 – 3634TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor IIIB 50 kDa subunit
    Alternative name(s):
    B-related factor 2
    Short name:
    BRF-2
    Gene namesi
    Name:brf2
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-964408. brf2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Transcription factor IIIB 50 kDa subunitPRO_0000337193Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA4QNR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati173 – 249772Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.Curated
    Contains 1 TFIIB-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri3 – 3634TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG107537.
    KOiK15197.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.
    PROSITEiPS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4QNR3-1 [UniParc]FASTAAdd to Basket

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    MSGAKQCPDC GSSDIVEDAH YSQDQVVCAD CGCILSEGLI TTTAAEESHL    50
    QAVRFADSTG ENDSMTVSKL RGIVRVRNIC RVLRLPDGFS DTAVSYYEQA 100
    YKHPLYHSVS IEKKEIIVGC CVYITCRQHQ WPITMATICS LVYAKKELFA 150
    SIFLSIVQVL KLDVPSVSLQ NLVMSHCRSF KLFKDSCEVP SHYAEKLDTV 200
    SERTVQTVEL AYETWLVTGR HPIPIITAAA YISWQSLLPA RRLSCSLSRF 250
    CKLSDVDLPP PSAIRLRELQ GTLIKLSVYL PWLKVLSLNK KTVVQHLGDL 300
    LRHRVFLLRK ALAVTEAELS RGTLADTEAQ LSRGTLADTE AQLSRGTLAD 350
    TEAQLSRGTL ADTEAQLSRG TLADTEAQLS RGTLADTEAQ LSRGTLADTE 400
    AQLSRGTLAD TEAQLSRGTL ADTVAQLSRG TLADTEAQLS RGTKALSSND 450
    QPNSTFVFLP PCVSNPRKRS RSIPFPRGHL DITGDEDISD SEIEQYLRTP 500
    AEMKEFEQAL NRDDELPNA 519
    Length:519
    Mass (Da):57,126
    Last modified:May 15, 2007 - v1
    Checksum:i55564CD7F1E36AF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136234 mRNA. Translation: AAI36235.1.
    RefSeqiNP_001096549.1. NM_001103079.1.
    UniGeneiStr.53387.

    Genome annotation databases

    GeneIDi100125194.
    KEGGixtr:100125194.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136234 mRNA. Translation: AAI36235.1 .
    RefSeqi NP_001096549.1. NM_001103079.1.
    UniGenei Str.53387.

    3D structure databases

    ProteinModelPortali A4QNR3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100125194.
    KEGGi xtr:100125194.

    Organism-specific databases

    CTDi 55290.
    Xenbasei XB-GENE-964408. brf2.

    Phylogenomic databases

    HOVERGENi HBG107537.
    KOi K15197.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    PROSITEi PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiBRF2_XENTR
    AccessioniPrimary (citable) accession number: A4QNR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3