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A4QNR3 (BRF2_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor IIIB 50 kDa subunit
Alternative name(s):
B-related factor 2
Short name=BRF-2
Gene names
Name:brf2
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TFIIB family.

Contains 1 TFIIB-type zinc finger.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA-templated transcription, initiation

Inferred from electronic annotation. Source: InterPro

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Transcription factor IIIB 50 kDa subunit
PRO_0000337193

Regions

Repeat173 – 249772
Zinc finger3 – 3634TFIIB-type

Sites

Metal binding71Zinc By similarity
Metal binding101Zinc By similarity
Metal binding281Zinc By similarity
Metal binding311Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QNR3 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 55564CD7F1E36AF6

FASTA51957,126
        10         20         30         40         50         60 
MSGAKQCPDC GSSDIVEDAH YSQDQVVCAD CGCILSEGLI TTTAAEESHL QAVRFADSTG 

        70         80         90        100        110        120 
ENDSMTVSKL RGIVRVRNIC RVLRLPDGFS DTAVSYYEQA YKHPLYHSVS IEKKEIIVGC 

       130        140        150        160        170        180 
CVYITCRQHQ WPITMATICS LVYAKKELFA SIFLSIVQVL KLDVPSVSLQ NLVMSHCRSF 

       190        200        210        220        230        240 
KLFKDSCEVP SHYAEKLDTV SERTVQTVEL AYETWLVTGR HPIPIITAAA YISWQSLLPA 

       250        260        270        280        290        300 
RRLSCSLSRF CKLSDVDLPP PSAIRLRELQ GTLIKLSVYL PWLKVLSLNK KTVVQHLGDL 

       310        320        330        340        350        360 
LRHRVFLLRK ALAVTEAELS RGTLADTEAQ LSRGTLADTE AQLSRGTLAD TEAQLSRGTL 

       370        380        390        400        410        420 
ADTEAQLSRG TLADTEAQLS RGTLADTEAQ LSRGTLADTE AQLSRGTLAD TEAQLSRGTL 

       430        440        450        460        470        480 
ADTVAQLSRG TLADTEAQLS RGTKALSSND QPNSTFVFLP PCVSNPRKRS RSIPFPRGHL 

       490        500        510 
DITGDEDISD SEIEQYLRTP AEMKEFEQAL NRDDELPNA 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC136234 mRNA. Translation: AAI36235.1.
RefSeqNP_001096549.1. NM_001103079.1.
UniGeneStr.53387.

3D structure databases

ProteinModelPortalA4QNR3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100125194.
KEGGxtr:100125194.

Organism-specific databases

CTD55290.
XenbaseXB-GENE-964408. brf2.

Phylogenomic databases

HOVERGENHBG107537.
KOK15197.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERPTHR11618. PTHR11618. 1 hit.
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 1 hit.
[Graphical view]
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 1 hit.
PROSITEPS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBRF2_XENTR
AccessionPrimary (citable) accession number: A4QNR3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families