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A4QNR3

- BRF2_XENTR

UniProt

A4QNR3 - BRF2_XENTR

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Protein
Transcription factor IIIB 50 kDa subunit
Gene
brf2
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites By similarity.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Zinc By similarity
Metal bindingi10 – 101Zinc By similarity
Metal bindingi28 – 281Zinc By similarity
Metal bindingi31 – 311Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 3634TFIIB-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, initiation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIB 50 kDa subunit
Alternative name(s):
B-related factor 2
Short name:
BRF-2
Gene namesi
Name:brf2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-964408. brf2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Transcription factor IIIB 50 kDa subunit
PRO_0000337193Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA4QNR3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati173 – 249772
Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG107537.
KOiK15197.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiPS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QNR3-1 [UniParc]FASTAAdd to Basket

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MSGAKQCPDC GSSDIVEDAH YSQDQVVCAD CGCILSEGLI TTTAAEESHL    50
QAVRFADSTG ENDSMTVSKL RGIVRVRNIC RVLRLPDGFS DTAVSYYEQA 100
YKHPLYHSVS IEKKEIIVGC CVYITCRQHQ WPITMATICS LVYAKKELFA 150
SIFLSIVQVL KLDVPSVSLQ NLVMSHCRSF KLFKDSCEVP SHYAEKLDTV 200
SERTVQTVEL AYETWLVTGR HPIPIITAAA YISWQSLLPA RRLSCSLSRF 250
CKLSDVDLPP PSAIRLRELQ GTLIKLSVYL PWLKVLSLNK KTVVQHLGDL 300
LRHRVFLLRK ALAVTEAELS RGTLADTEAQ LSRGTLADTE AQLSRGTLAD 350
TEAQLSRGTL ADTEAQLSRG TLADTEAQLS RGTLADTEAQ LSRGTLADTE 400
AQLSRGTLAD TEAQLSRGTL ADTVAQLSRG TLADTEAQLS RGTKALSSND 450
QPNSTFVFLP PCVSNPRKRS RSIPFPRGHL DITGDEDISD SEIEQYLRTP 500
AEMKEFEQAL NRDDELPNA 519
Length:519
Mass (Da):57,126
Last modified:May 15, 2007 - v1
Checksum:i55564CD7F1E36AF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136234 mRNA. Translation: AAI36235.1.
RefSeqiNP_001096549.1. NM_001103079.1.
UniGeneiStr.53387.

Genome annotation databases

GeneIDi100125194.
KEGGixtr:100125194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136234 mRNA. Translation: AAI36235.1 .
RefSeqi NP_001096549.1. NM_001103079.1.
UniGenei Str.53387.

3D structure databases

ProteinModelPortali A4QNR3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100125194.
KEGGi xtr:100125194.

Organism-specific databases

CTDi 55290.
Xenbasei XB-GENE-964408. brf2.

Phylogenomic databases

HOVERGENi HBG107537.
KOi K15197.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
PROSITEi PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiBRF2_XENTR
AccessioniPrimary (citable) accession number: A4QNR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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