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A4QNN3

- UBP30_XENTR

UniProt

A4QNN3 - UBP30_XENTR

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Protein

Ubiquitin carboxyl-terminal hydrolase 30

Gene

usp30

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park2).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941NucleophilePROSITE-ProRule annotation
Active sitei455 – 4551Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. mitochondrial fusion Source: UniProtKB
  2. mitochondrion degradation Source: UniProtKB
  3. protein deubiquitination Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 30 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 30
Ubiquitin thioesterase 30
Ubiquitin-specific-processing protease 30
Short name:
Ub-specific protease 30
Gene namesi
Name:usp30
ORF Names:TEgg099b09.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-981069. usp30.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Ubiquitin carboxyl-terminal hydrolase 30PRO_0000377539Add
BLAST

Expressioni

Gene expression databases

BgeeiA4QNN3.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000048254.

Structurei

3D structure databases

ProteinModelPortaliA4QNN3.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini74 – 519446CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 504420USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00550000075075.
HOGENOMiHOG000065744.
InParanoidiA4QNN3.
KOiK11851.
OMAiVCDNCTR.
OrthoDBiEOG7P8P7N.
TreeFamiTF105781.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QNN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWAPVSTWS RRTPLAACCS APELPPAGAW KACAAGSLRI GPQGRCKMMK
60 70 80 90 100
NWGMIGGIAA ALAAGIYVLW GPISDRKKYR KGLVPGLLNL GNTCFMNSLL
110 120 130 140 150
QGLASCPSFI RWLADFTSKY RQENNTTEHQ HLSVTLLHLL KALCNQEGTE
160 170 180 190 200
DEVLDASPLL EVLRAHRWQI SSFEEQDAHE LFHVLTSSLE DERDRRPHVT
210 220 230 240 250
HLFDLDSLEF PLEPQRQIHC RTQVPIYPIP SQWKSQHPFH GRLTSNMVCK
260 270 280 290 300
HCQHQSPMRY DTFDSLSLSI PVATWGHPIT LDQCLQHFIS TESVKDVVCE
310 320 330 340 350
NCTKIHAAQI PNSQSVENRK TTFVKQLKLG KLPQCLCIHL QRLSWSNQGS
360 370 380 390 400
PLKRNEHVQF SEFLAMDRFK YRISGCSTSK QPANHLSAAE QETTDGKEGG
410 420 430 440 450
AQNPTMPFLN GACSTSYISP PFTSPLPTNP EWTSSSYLFR LMAVVVHHGD
460 470 480 490 500
MHSGHFVTYR RSPAAKNQKL TSQQWLWISD DTVRRTNFQE VLSSSAYLLF
510
YERIQSNLHH PEDQRAAEK
Length:519
Mass (Da):58,683
Last modified:May 15, 2007 - v1
Checksum:i31FC4F6B8309D7E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611A → V in CAJ81380. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR926280 mRNA. Translation: CAJ81380.1.
BC135925 mRNA. Translation: AAI35926.1.
RefSeqiNP_001039085.1. NM_001045620.1.
UniGeneiStr.19890.

Genome annotation databases

EnsembliENSXETT00000048254; ENSXETP00000048254; ENSXETG00000022301.
GeneIDi733894.
KEGGixtr:733894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR926280 mRNA. Translation: CAJ81380.1 .
BC135925 mRNA. Translation: AAI35926.1 .
RefSeqi NP_001039085.1. NM_001045620.1.
UniGenei Str.19890.

3D structure databases

ProteinModelPortali A4QNN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000048254.

Protein family/group databases

MEROPSi C19.060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000048254 ; ENSXETP00000048254 ; ENSXETG00000022301 .
GeneIDi 733894.
KEGGi xtr:733894.

Organism-specific databases

CTDi 84749.
Xenbasei XB-GENE-981069. usp30.

Phylogenomic databases

eggNOGi COG5533.
GeneTreei ENSGT00550000075075.
HOGENOMi HOG000065744.
InParanoidi A4QNN3.
KOi K11851.
OMAi VCDNCTR.
OrthoDBi EOG7P8P7N.
TreeFami TF105781.

Gene expression databases

Bgeei A4QNN3.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tadpole.

Entry informationi

Entry nameiUBP30_XENTR
AccessioniPrimary (citable) accession number: A4QNN3
Secondary accession number(s): Q28CN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3