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A4QNN3 (UBP30_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 30

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 30
Ubiquitin thioesterase 30
Ubiquitin-specific-processing protease 30
Short name=Ub-specific protease 30
Gene names
Name:usp30
ORF Names:TEgg099b09.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May participate in the maintenance of mitochondrial morphology By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Mitochondrion outer membrane By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Ubiquitin carboxyl-terminal hydrolase 30
PRO_0000377539

Regions

Topological domain1 – 5252Mitochondrial intermembrane Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 519446Cytoplasmic Potential
Domain85 – 504420USP

Sites

Active site941Nucleophile By similarity
Active site4551Proton acceptor By similarity

Experimental info

Sequence conflict611A → V in CAJ81380. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A4QNN3 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 31FC4F6B8309D7E7

FASTA51958,683
        10         20         30         40         50         60 
MSWAPVSTWS RRTPLAACCS APELPPAGAW KACAAGSLRI GPQGRCKMMK NWGMIGGIAA 

        70         80         90        100        110        120 
ALAAGIYVLW GPISDRKKYR KGLVPGLLNL GNTCFMNSLL QGLASCPSFI RWLADFTSKY 

       130        140        150        160        170        180 
RQENNTTEHQ HLSVTLLHLL KALCNQEGTE DEVLDASPLL EVLRAHRWQI SSFEEQDAHE 

       190        200        210        220        230        240 
LFHVLTSSLE DERDRRPHVT HLFDLDSLEF PLEPQRQIHC RTQVPIYPIP SQWKSQHPFH 

       250        260        270        280        290        300 
GRLTSNMVCK HCQHQSPMRY DTFDSLSLSI PVATWGHPIT LDQCLQHFIS TESVKDVVCE 

       310        320        330        340        350        360 
NCTKIHAAQI PNSQSVENRK TTFVKQLKLG KLPQCLCIHL QRLSWSNQGS PLKRNEHVQF 

       370        380        390        400        410        420 
SEFLAMDRFK YRISGCSTSK QPANHLSAAE QETTDGKEGG AQNPTMPFLN GACSTSYISP 

       430        440        450        460        470        480 
PFTSPLPTNP EWTSSSYLFR LMAVVVHHGD MHSGHFVTYR RSPAAKNQKL TSQQWLWISD 

       490        500        510 
DTVRRTNFQE VLSSSAYLLF YERIQSNLHH PEDQRAAEK 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tadpole.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR926280 mRNA. Translation: CAJ81380.1.
BC135925 mRNA. Translation: AAI35926.1.
RefSeqNP_001039085.1. NM_001045620.1.
UniGeneStr.19890.

3D structure databases

ProteinModelPortalA4QNN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000048254.

Protein family/group databases

MEROPSC19.060.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000048254; ENSXETP00000048254; ENSXETG00000022301.
GeneID733894.
KEGGxtr:733894.

Organism-specific databases

CTD84749.
XenbaseXB-GENE-981069. usp30.

Phylogenomic databases

eggNOGCOG5533.
GeneTreeENSGT00550000075075.
HOGENOMHOG000065744.
KOK11851.
OMAATSSQWL.
OrthoDBEOG7P8P7N.
TreeFamTF105781.

Gene expression databases

BgeeA4QNN3.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP30_XENTR
AccessionPrimary (citable) accession number: A4QNN3
Secondary accession number(s): Q28CN8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 15, 2007
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries