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A4QNA8

- WEE2_XENTR

UniProt

A4QNA8 - WEE2_XENTR

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Protein

Wee1-like protein kinase 2

Gene

wee2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiotic reentry (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei246 – 2461ATPPROSITE-ProRule annotation
Active sitei344 – 3441Proton acceptorPROSITE-ProRule annotation
Metal bindingi349 – 3491Magnesium; via carbonyl oxygenBy similarity
Metal bindingi381 – 3811Magnesium; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi223 – 2319ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  4. protein serine/threonine kinase activity Source: InterPro

GO - Biological processi

  1. meiotic nuclear division Source: UniProtKB-KW
  2. mitotic nuclear division Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Meiosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Wee1-like protein kinase 2 (EC:2.7.10.2)
Gene namesi
Name:wee2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5560750. wee2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Wee1-like protein kinase 2PRO_0000409531Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA4QNA8.
SMRiA4QNA8. Positions 209-487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini217 – 491275Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili494 – 52027Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG005050.
InParanoidiA4QNA8.
KOiK06632.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR017164. Wee1-like_protein_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037281. Wee1-like_protein_kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QNA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTAMSCGGG LAQRLDFSSS DEEDGMSPGL EEGSHSNQRG SPVNSWRANN
60 70 80 90 100
CPFPITPQRN ERGLSPSQEE LSPCSDYSPV PSDKGVGGEC PGTPLHYSTW
110 120 130 140 150
KKLKLCDTPY TPKSLLYKTL PSPGSRVQCR GQRLLRFVAG TGAELDDPAL
160 170 180 190 200
VNVNPFTPES YRQANFHPNG KRKERPEDDC SAEPQMKYAE KEHPAVFQSK
210 220 230 240 250
RFVLRETNMV SRYKTEFLEI EKIGAGEFGS VFKCVKRLDG CFYAIKRSKK
260 270 280 290 300
PLAGSTDEQL ALREVYAHAV LGHHPHVVRY YSAWAEDDHM IIQNEYCNGG
310 320 330 340 350
SLQDLIMENK KEGRFVPEQE LKEILLQVSM GLKYIHSSGL VHMDIKPSNI
360 370 380 390 400
FICRKQTEVG QDESDGEDDL SSASVLYKIG DLGHVTSILN PQVEEGDSRF
410 420 430 440 450
LANEILQEDY RQLPKADIFA LGLTITLAAG AGPLPCNEDS WHHIRKGNLP
460 470 480 490 500
HIPQPLTPAF LALLKLLVHP DPVMRPPAVS LAKNSLLRRC VGKAAQLQKQ
510 520 530 540 550
LNVEKFKTAM LERELKAAKL AHGSGKDECS DLPPMSDFSC RGRKRLVGAK
560
NARSLSFTCG GY
Length:562
Mass (Da):62,352
Last modified:May 15, 2007 - v1
Checksum:iA3196C6BDB9CC54F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC135215 mRNA. Translation: AAI35216.1.
RefSeqiNP_001096499.1. NM_001103029.1.
UniGeneiStr.25897.

Genome annotation databases

GeneIDi100125126.
KEGGixtr:100125126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC135215 mRNA. Translation: AAI35216.1 .
RefSeqi NP_001096499.1. NM_001103029.1.
UniGenei Str.25897.

3D structure databases

ProteinModelPortali A4QNA8.
SMRi A4QNA8. Positions 209-487.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100125126.
KEGGi xtr:100125126.

Organism-specific databases

CTDi 494551.
Xenbasei XB-GENE-5560750. wee2.

Phylogenomic databases

HOVERGENi HBG005050.
InParanoidi A4QNA8.
KOi K06632.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR017164. Wee1-like_protein_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF037281. Wee1-like_protein_kinase. 1 hit.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiWEE2_XENTR
AccessioniPrimary (citable) accession number: A4QNA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3