Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4QNA8

- WEE2_XENTR

UniProt

A4QNA8 - WEE2_XENTR

Protein

Wee1-like protein kinase 2

Gene

wee2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiotic reentry By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei246 – 2461ATPPROSITE-ProRule annotation
    Active sitei344 – 3441Proton acceptorPROSITE-ProRule annotation
    Metal bindingi349 – 3491Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi381 – 3811Magnesium; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi223 – 2319ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    4. protein serine/threonine kinase activity Source: InterPro

    GO - Biological processi

    1. meiotic nuclear division Source: UniProtKB-KW
    2. mitotic nuclear division Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Meiosis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Wee1-like protein kinase 2 (EC:2.7.10.2)
    Gene namesi
    Name:wee2
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5560750. wee2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Wee1-like protein kinase 2PRO_0000409531Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA4QNA8.
    SMRiA4QNA8. Positions 209-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini217 – 491275Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili494 – 52027Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOVERGENiHBG005050.
    KOiK06632.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR017164. Wee1-like_protein_kinase.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037281. Wee1-like_protein_kinase. 1 hit.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4QNA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTAMSCGGG LAQRLDFSSS DEEDGMSPGL EEGSHSNQRG SPVNSWRANN    50
    CPFPITPQRN ERGLSPSQEE LSPCSDYSPV PSDKGVGGEC PGTPLHYSTW 100
    KKLKLCDTPY TPKSLLYKTL PSPGSRVQCR GQRLLRFVAG TGAELDDPAL 150
    VNVNPFTPES YRQANFHPNG KRKERPEDDC SAEPQMKYAE KEHPAVFQSK 200
    RFVLRETNMV SRYKTEFLEI EKIGAGEFGS VFKCVKRLDG CFYAIKRSKK 250
    PLAGSTDEQL ALREVYAHAV LGHHPHVVRY YSAWAEDDHM IIQNEYCNGG 300
    SLQDLIMENK KEGRFVPEQE LKEILLQVSM GLKYIHSSGL VHMDIKPSNI 350
    FICRKQTEVG QDESDGEDDL SSASVLYKIG DLGHVTSILN PQVEEGDSRF 400
    LANEILQEDY RQLPKADIFA LGLTITLAAG AGPLPCNEDS WHHIRKGNLP 450
    HIPQPLTPAF LALLKLLVHP DPVMRPPAVS LAKNSLLRRC VGKAAQLQKQ 500
    LNVEKFKTAM LERELKAAKL AHGSGKDECS DLPPMSDFSC RGRKRLVGAK 550
    NARSLSFTCG GY 562
    Length:562
    Mass (Da):62,352
    Last modified:May 15, 2007 - v1
    Checksum:iA3196C6BDB9CC54F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC135215 mRNA. Translation: AAI35216.1.
    RefSeqiNP_001096499.1. NM_001103029.1.
    UniGeneiStr.25897.

    Genome annotation databases

    GeneIDi100125126.
    KEGGixtr:100125126.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC135215 mRNA. Translation: AAI35216.1 .
    RefSeqi NP_001096499.1. NM_001103029.1.
    UniGenei Str.25897.

    3D structure databases

    ProteinModelPortali A4QNA8.
    SMRi A4QNA8. Positions 209-487.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100125126.
    KEGGi xtr:100125126.

    Organism-specific databases

    CTDi 494551.
    Xenbasei XB-GENE-5560750. wee2.

    Phylogenomic databases

    HOVERGENi HBG005050.
    KOi K06632.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR017164. Wee1-like_protein_kinase.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037281. Wee1-like_protein_kinase. 1 hit.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiWEE2_XENTR
    AccessioniPrimary (citable) accession number: A4QNA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3