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A4QNA8 (WEE2_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 11, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Wee1-like protein kinase 2
EC=2.7.10.2
Gene names
Name:wee2
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiotic reentry By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Wee1-like protein kinase 2
PRO_0000409531

Regions

Domain217 – 491275Protein kinase
Nucleotide binding223 – 2319ATP By similarity
Coiled coil494 – 52027 Potential

Sites

Active site3441Proton acceptor By similarity
Metal binding3491Magnesium; via carbonyl oxygen By similarity
Metal binding3811Magnesium; via carbonyl oxygen By similarity
Binding site2461ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QNA8 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: A3196C6BDB9CC54F

FASTA56262,352
        10         20         30         40         50         60 
MRTAMSCGGG LAQRLDFSSS DEEDGMSPGL EEGSHSNQRG SPVNSWRANN CPFPITPQRN 

        70         80         90        100        110        120 
ERGLSPSQEE LSPCSDYSPV PSDKGVGGEC PGTPLHYSTW KKLKLCDTPY TPKSLLYKTL 

       130        140        150        160        170        180 
PSPGSRVQCR GQRLLRFVAG TGAELDDPAL VNVNPFTPES YRQANFHPNG KRKERPEDDC 

       190        200        210        220        230        240 
SAEPQMKYAE KEHPAVFQSK RFVLRETNMV SRYKTEFLEI EKIGAGEFGS VFKCVKRLDG 

       250        260        270        280        290        300 
CFYAIKRSKK PLAGSTDEQL ALREVYAHAV LGHHPHVVRY YSAWAEDDHM IIQNEYCNGG 

       310        320        330        340        350        360 
SLQDLIMENK KEGRFVPEQE LKEILLQVSM GLKYIHSSGL VHMDIKPSNI FICRKQTEVG 

       370        380        390        400        410        420 
QDESDGEDDL SSASVLYKIG DLGHVTSILN PQVEEGDSRF LANEILQEDY RQLPKADIFA 

       430        440        450        460        470        480 
LGLTITLAAG AGPLPCNEDS WHHIRKGNLP HIPQPLTPAF LALLKLLVHP DPVMRPPAVS 

       490        500        510        520        530        540 
LAKNSLLRRC VGKAAQLQKQ LNVEKFKTAM LERELKAAKL AHGSGKDECS DLPPMSDFSC 

       550        560 
RGRKRLVGAK NARSLSFTCG GY

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC135215 mRNA. Translation: AAI35216.1.
RefSeqNP_001096499.1. NM_001103029.1.
UniGeneStr.25897.

3D structure databases

ProteinModelPortalA4QNA8.
SMRA4QNA8. Positions 209-487.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100125126.
KEGGxtr:100125126.

Organism-specific databases

CTD494551.
XenbaseXB-GENE-5560750. wee2.

Phylogenomic databases

HOVERGENHBG005050.
KOK06632.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR017164. Wee1-like_protein_kinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF037281. Wee1-like_protein_kinase. 1 hit.
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWEE2_XENTR
AccessionPrimary (citable) accession number: A4QNA8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 15, 2007
Last modified: July 11, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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