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A4QN31

- A4QN31_DANRE

UniProt

A4QN31 - A4QN31_DANRE

Protein

Fibroblast growth factor receptor

Gene

fgfr2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei533 – 5331Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fibroblast growth factor-activated receptor activity Source: InterPro

    GO - Biological processi

    1. embryonic cranial skeleton morphogenesis Source: InterPro
    2. positive regulation of cell proliferation Source: InterPro

    Keywords - Molecular functioni

    Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_204298. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_205098. Signaling by FGFR mutants.
    REACT_207707. Signaling by FGFR2 amplification mutants.
    REACT_211854. SHC-mediated cascade.
    REACT_223377. Activated point mutants of FGFR2.
    REACT_225510. Negative regulation of FGFR signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
    Gene namesi
    Name:fgfr2Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

    Organism-specific databases

    ZFINiZDB-GENE-030323-1. fgfr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Expressioni

    Gene expression databases

    BgeeiA4QN31.

    Structurei

    3D structure databases

    ProteinModelPortaliA4QN31.
    SMRiA4QN31. Positions 63-273, 375-672.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000263410.
    HOVERGENiHBG000345.
    KOiK05093.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR028175. FGF_rcpt_2.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
    PfamiPF07679. I-set. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000628. FGFR. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00408. IGc2. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4QN31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFARGWLLGA LLLMTLATVS VARPSLKIDL VNTSAPEDAI SSGDDEDDTE    50
    RSDDVGADGE QMRLPYWTFP EKMEKKLHAV PAANTVKFRC AAAGNPKPKM 100
    RWLKNAKPFR QEDRMGGYKV RLQHWTLIME SVVPSDKGNY TCLVENQYGS 150
    INHTYTLDVV ERSPHRPILQ AGLPANVTVQ VGQDAKFVCK VYSDAQPHIQ 200
    WLQHYTKNGS RYGPDGLPYV RVLKTAGVNT TDKEIEVLYL PNVTFEDAGE 250
    YTCLAGNSIG ISYHTAWLTV HPAETNPIET DYPPDYVEIA IYCIGVFLIA 300
    CMVVIVVVCR MRTSAKKPDF SSQPAVHKLT KQIPLRRQVT VSSDSSSSMS 350
    SSTPLVRITT RRSSAHDDPI PEYDLPEDPR WEFSRDKLTL GKPLGEGCFG 400
    QVVMAEALGI DKDKPKEAVT VAVKMLKDDA TEKDLSDLVS EMEMMKMIGR 450
    HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLRARRPPG MEYSYDIARV 500
    SDEPLTFKDL VSCTYQVARG MEYLASQKCI HRDLAARNVL VTESNVMKIA 550
    DFGLARDVHN IDYYKKTTNG RLPVKWMAPE ALFDRVYTHQ SDVWSFGVLM 600
    WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPANCTNELY MMMKDCWHAI 650
    SSHRPTFKQL VEDLDRILTL ATNEEYLDLC APVEQYSPSF PDTRSSCSSG 700
    DDSVFSHDPL ADEPCLPKYQ HINGGIKT 728
    Length:728
    Mass (Da):81,771
    Last modified:May 15, 2007 - v1
    Checksum:i14898E3DBE3883F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134807 mRNA. Translation: AAI34808.1.
    RefSeqiNP_001229935.1. NM_001243006.1.
    UniGeneiDr.116399.
    Dr.31427.

    Genome annotation databases

    GeneIDi352940.
    KEGGidre:352940.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134807 mRNA. Translation: AAI34808.1 .
    RefSeqi NP_001229935.1. NM_001243006.1.
    UniGenei Dr.116399.
    Dr.31427.

    3D structure databases

    ProteinModelPortali A4QN31.
    SMRi A4QN31. Positions 63-273, 375-672.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 352940.
    KEGGi dre:352940.

    Organism-specific databases

    CTDi 2263.
    ZFINi ZDB-GENE-030323-1. fgfr2.

    Phylogenomic databases

    HOGENOMi HOG000263410.
    HOVERGENi HBG000345.
    KOi K05093.

    Enzyme and pathway databases

    Reactomei REACT_204298. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_205098. Signaling by FGFR mutants.
    REACT_207707. Signaling by FGFR2 amplification mutants.
    REACT_211854. SHC-mediated cascade.
    REACT_223377. Activated point mutants of FGFR2.
    REACT_225510. Negative regulation of FGFR signaling.

    Miscellaneous databases

    NextBioi 20812681.

    Gene expression databases

    Bgeei A4QN31.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR028175. FGF_rcpt_2.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
    Pfami PF07679. I-set. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000628. FGFR. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00408. IGc2. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiA4QN31_DANRE
    AccessioniPrimary (citable) accession number: A4QN31
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)