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Protein

Fibroblast growth factor receptor

Gene

fgfr2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei533 – 5331Proton acceptorUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fibroblast growth factor-activated receptor activity Source: InterPro

GO - Biological processi

  1. embryonic cranial skeleton morphogenesis Source: InterPro
  2. positive regulation of cell proliferation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_204298. Constitutive PI3K/AKT Signaling in Cancer.
REACT_205098. Signaling by FGFR mutants.
REACT_207707. Signaling by FGFR2 amplification mutants.
REACT_211854. SHC-mediated cascade.
REACT_223377. Activated point mutants of FGFR2.
REACT_225510. Negative regulation of FGFR signaling.
REACT_234868. PI-3K cascade.
REACT_239502. PI3K Cascade.
REACT_240056. FGFR2b ligand binding and activation.
REACT_248177. PIP3 activates AKT signaling.
REACT_256105. FGFR2c ligand binding and activation.
REACT_262090. Phospholipase C-mediated cascade.
REACT_262311. FRS2-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:fgfr2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030323-1. fgfr2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Expressioni

Gene expression databases

BgeeiA4QN31.

Structurei

3D structure databases

ProteinModelPortaliA4QN31.
SMRiA4QN31. Positions 63-273, 375-672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000263410.
HOVERGENiHBG000345.
KOiK05093.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QN31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFARGWLLGA LLLMTLATVS VARPSLKIDL VNTSAPEDAI SSGDDEDDTE
60 70 80 90 100
RSDDVGADGE QMRLPYWTFP EKMEKKLHAV PAANTVKFRC AAAGNPKPKM
110 120 130 140 150
RWLKNAKPFR QEDRMGGYKV RLQHWTLIME SVVPSDKGNY TCLVENQYGS
160 170 180 190 200
INHTYTLDVV ERSPHRPILQ AGLPANVTVQ VGQDAKFVCK VYSDAQPHIQ
210 220 230 240 250
WLQHYTKNGS RYGPDGLPYV RVLKTAGVNT TDKEIEVLYL PNVTFEDAGE
260 270 280 290 300
YTCLAGNSIG ISYHTAWLTV HPAETNPIET DYPPDYVEIA IYCIGVFLIA
310 320 330 340 350
CMVVIVVVCR MRTSAKKPDF SSQPAVHKLT KQIPLRRQVT VSSDSSSSMS
360 370 380 390 400
SSTPLVRITT RRSSAHDDPI PEYDLPEDPR WEFSRDKLTL GKPLGEGCFG
410 420 430 440 450
QVVMAEALGI DKDKPKEAVT VAVKMLKDDA TEKDLSDLVS EMEMMKMIGR
460 470 480 490 500
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLRARRPPG MEYSYDIARV
510 520 530 540 550
SDEPLTFKDL VSCTYQVARG MEYLASQKCI HRDLAARNVL VTESNVMKIA
560 570 580 590 600
DFGLARDVHN IDYYKKTTNG RLPVKWMAPE ALFDRVYTHQ SDVWSFGVLM
610 620 630 640 650
WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPANCTNELY MMMKDCWHAI
660 670 680 690 700
SSHRPTFKQL VEDLDRILTL ATNEEYLDLC APVEQYSPSF PDTRSSCSSG
710 720
DDSVFSHDPL ADEPCLPKYQ HINGGIKT
Length:728
Mass (Da):81,771
Last modified:May 15, 2007 - v1
Checksum:i14898E3DBE3883F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134807 mRNA. Translation: AAI34808.1.
RefSeqiNP_001229935.1. NM_001243006.1.
UniGeneiDr.116399.
Dr.31427.

Genome annotation databases

GeneIDi352940.
KEGGidre:352940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134807 mRNA. Translation: AAI34808.1.
RefSeqiNP_001229935.1. NM_001243006.1.
UniGeneiDr.116399.
Dr.31427.

3D structure databases

ProteinModelPortaliA4QN31.
SMRiA4QN31. Positions 63-273, 375-672.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi352940.
KEGGidre:352940.

Organism-specific databases

CTDi2263.
ZFINiZDB-GENE-030323-1. fgfr2.

Phylogenomic databases

HOGENOMiHOG000263410.
HOVERGENiHBG000345.
KOiK05093.

Enzyme and pathway databases

ReactomeiREACT_204298. Constitutive PI3K/AKT Signaling in Cancer.
REACT_205098. Signaling by FGFR mutants.
REACT_207707. Signaling by FGFR2 amplification mutants.
REACT_211854. SHC-mediated cascade.
REACT_223377. Activated point mutants of FGFR2.
REACT_225510. Negative regulation of FGFR signaling.
REACT_234868. PI-3K cascade.
REACT_239502. PI3K Cascade.
REACT_240056. FGFR2b ligand binding and activation.
REACT_248177. PIP3 activates AKT signaling.
REACT_256105. FGFR2c ligand binding and activation.
REACT_262090. Phospholipase C-mediated cascade.
REACT_262311. FRS2-mediated cascade.

Miscellaneous databases

NextBioi20812681.

Gene expression databases

BgeeiA4QN31.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.

Entry informationi

Entry nameiA4QN31_DANRE
AccessioniPrimary (citable) accession number: A4QN31
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.