ID CFA90_HUMAN Reviewed; 147 AA. AC A4QMS7; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 15-MAY-2007, sequence version 1. DT 24-JAN-2024, entry version 102. DE RecName: Full=Cilia- and flagella-associated protein 90; GN Name=CFAP90 {ECO:0000312|HGNC:HGNC:27028}; Synonyms=C5orf49; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS) IN ASSOCIATION WITH RP MICROTUBULES, SUBCELLULAR LOCATION, AND FUNCTION. RX PubMed=36191189; DOI=10.1073/pnas.2207605119; RA Gui M., Croft J.T., Zabeo D., Acharya V., Kollman J.M., Burgoyne T., RA Hoog J.L., Brown A.; RT "SPACA9 is a lumenal protein of human ciliary singlet and doublet RT microtubules."; RL Proc. Natl. Acad. Sci. U.S.A. 119:e2207605119-e2207605119(2022). CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated CC doublet microtubules (DMTs) in cilia axoneme, which is required for CC motile cilia beating. {ECO:0000269|PubMed:36191189}. CC -!- INTERACTION: CC A4QMS7; P55273: CDKN2D; NbExp=3; IntAct=EBI-12039847, EBI-745859; CC A4QMS7; O75031: HSF2BP; NbExp=3; IntAct=EBI-12039847, EBI-7116203; CC A4QMS7; Q15323: KRT31; NbExp=3; IntAct=EBI-12039847, EBI-948001; CC A4QMS7; O76011: KRT34; NbExp=3; IntAct=EBI-12039847, EBI-1047093; CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme CC {ECO:0000269|PubMed:36191189}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH471102; EAX08096.1; -; Genomic_DNA. DR EMBL; BC104205; AAI04206.1; -; mRNA. DR EMBL; BC115361; AAI15362.1; -; mRNA. DR CCDS; CCDS43300.1; -. DR RefSeq; NP_001083053.1; NM_001089584.2. DR PDB; 7UNG; EM; 3.60 A; L1/L2=1-147. DR PDB; 8J07; EM; 4.10 A; 5X/5Y=1-147. DR PDBsum; 7UNG; -. DR PDBsum; 8J07; -. DR AlphaFoldDB; A4QMS7; -. DR EMDB; EMD-26624; -. DR EMDB; EMD-35888; -. DR SMR; A4QMS7; -. DR BioGRID; 126385; 4. DR IntAct; A4QMS7; 4. DR STRING; 9606.ENSP00000382708; -. DR iPTMnet; A4QMS7; -. DR PhosphoSitePlus; A4QMS7; -. DR BioMuta; C5orf49; -. DR MassIVE; A4QMS7; -. DR PaxDb; 9606-ENSP00000382708; -. DR PeptideAtlas; A4QMS7; -. DR ProteomicsDB; 684; -. DR Antibodypedia; 64337; 39 antibodies from 8 providers. DR DNASU; 134121; -. DR Ensembl; ENST00000399810.7; ENSP00000382708.2; ENSG00000215217.7. DR GeneID; 134121; -. DR KEGG; hsa:134121; -. DR MANE-Select; ENST00000399810.7; ENSP00000382708.2; NM_001089584.3; NP_001083053.1. DR UCSC; uc003jea.7; human. DR AGR; HGNC:27028; -. DR CTD; 134121; -. DR GeneCards; CFAP90; -. DR HGNC; HGNC:27028; CFAP90. DR HPA; ENSG00000215217; Group enriched (brain, choroid plexus, fallopian tube, testis). DR neXtProt; NX_A4QMS7; -. DR OpenTargets; ENSG00000215217; -. DR PharmGKB; PA162380347; -. DR VEuPathDB; HostDB:ENSG00000215217; -. DR eggNOG; ENOG502S3H1; Eukaryota. DR GeneTree; ENSGT00390000015121; -. DR HOGENOM; CLU_127177_0_0_1; -. DR InParanoid; A4QMS7; -. DR OMA; GYNNKLH; -. DR OrthoDB; 2907622at2759; -. DR PhylomeDB; A4QMS7; -. DR TreeFam; TF328385; -. DR PathwayCommons; A4QMS7; -. DR SignaLink; A4QMS7; -. DR BioGRID-ORCS; 134121; 15 hits in 1111 CRISPR screens. DR ChiTaRS; C5orf49; human. DR GenomeRNAi; 134121; -. DR Pharos; A4QMS7; Tdark. DR PRO; PR:A4QMS7; -. DR Proteomes; UP000005640; Chromosome 5. DR RNAct; A4QMS7; Protein. DR Bgee; ENSG00000215217; Expressed in right uterine tube and 99 other cell types or tissues. DR ExpressionAtlas; A4QMS7; baseline and differential. DR GO; GO:0005930; C:axoneme; IDA:UniProtKB. DR GO; GO:0036064; C:ciliary basal body; IDA:GO_Central. DR InterPro; IPR027901; CFAP90. DR PANTHER; PTHR34444; LOC361192; 1. DR PANTHER; PTHR34444:SF1; LOC361192; 1. DR Pfam; PF15074; DUF4541; 1. DR Genevisible; A4QMS7; HS. PE 1: Evidence at protein level; KW 3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome. FT CHAIN 1..147 FT /note="Cilia- and flagella-associated protein 90" FT /id="PRO_0000336090" FT REGION 1..36 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 68 FT /note="Q -> H (in dbSNP:rs6883562)" FT /id="VAR_043546" FT VARIANT 87 FT /note="E -> K (in dbSNP:rs16879215)" FT /id="VAR_043547" FT VARIANT 139 FT /note="P -> S (in dbSNP:rs326181)" FT /id="VAR_043548" SQ SEQUENCE 147 AA; 16991 MW; 7062F33544448479 CRC64; MEDDEEETTA STLRGKPRPP PVSAQSAFSY IPPRRLDPKE HSYYYRPART GIISLYDCIF KRRLDYDQKL HRDDREHAKS LGLHVNEEEQ ERPVGVLTSS VYGKRINQPI EPLNRDFGRA NHVQADFYRK NDIPSLKEPG FGHIAPS //