A4QJY7 (NU1C_OLIPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase subunit 1
Short name=NDH subunit 1
NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:

ndhA

Encoded on

Plastid; Chloroplast

Organism

Olimarabidopsis pumila (Dwarf rocket) (Arabidopsis griffithiana)

Taxonomic identifier

74718 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Olimarabidopsis

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01350
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity HAMAP MF_01350.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000298877
Regions
	Transmembrane	27 – 47	21	Helical; Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	129 – 149	21	Helical; Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Transmembrane	203 – 223	21	Helical; Potential
	Transmembrane	248 – 268	21	Helical; Potential
	Transmembrane	269 – 289	21	Helical; Potential
	Transmembrane	297 – 317	21	Helical; Potential
	Transmembrane	340 – 360	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A4QJY7 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 6F320D4C353AAD0C	FASTA	360	40,137
	10 20 30 40 50 60 MIIYATVVQT INSFVRLESL KEVYGLIWIF VPIFSLVLGI ITGVLVIVWL EREISAGIQQ 70 80 90 100 110 120 RIGPEYAGPL GILQALADGT KLLFKENLRP SRGNTPLFSI GPSIAVISIL LSYSVIPFSN 130 140 150 160 170 180 HLVLADLNIG IFLWIAISSI APIGLLMSGY GSNNKYSFLG GLRAAAQSIS YEIPLTLCVL 190 200 210 220 230 240 SISLLSNSLS TVDIVEAQSK YGFWGWNLWR QPIGFIIFLI SSLAECERLP FDLPEAEEEL 250 260 270 280 290 300 IAGYQTEYSG IKFGLFYVAS YLNLLISSLF VTVLYLGGWN ISIPYISILE LFQRDQIFGT 310 320 330 340 350 360 TICIFITLAK TYLFLFISIA TRWTLPRLRM DQLLNLGWKF LLPISLGNLL LTTSFQLFSL

References

[1]	"Sequence analysis of Arabidopsis pumila JS2 chloroplast DNA." Hosouchi T., Tsuruoka H., Kotani H. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JS2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009368 Genomic DNA. Translation: BAF49995.1.
RefSeq	YP_001123170.1. NC_009267.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4962406.
Phylogenomic databases
ProtClustDB	CHL00032.
Family and domain databases
HAMAP	MF_01350. NDH1_NuoH. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1/FPO. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_OLIPU

Accession

Primary (citable) accession number: A4QJY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	May 15, 2007
Last modified:	June 28, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program