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A4QJE0

- CLPP_AETCO

UniProt

A4QJE0 - CLPP_AETCO

Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Aethionema cordifolium (Lebanon stonecress)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

    Catalytic activityi

    Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei101 – 1011NucleophileUniRule annotation
    Active sitei126 – 1261UniRule annotation

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
    Alternative name(s):
    Endopeptidase ClpUniRule annotation
    Gene namesi
    Name:clpPUniRule annotation
    Encoded oniPlastid; Chloroplast
    OrganismiAethionema cordifolium (Lebanon stonecress)
    Taxonomic identifieri434059 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeAethionemeaeAethionema

    Subcellular locationi

    Plastidchloroplast stroma UniRule annotation

    GO - Cellular componenti

    1. chloroplast stroma Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196ATP-dependent Clp protease proteolytic subunitPRO_0000309286Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the chloroplastic Clp protease core complex.

    Structurei

    3D structure databases

    ProteinModelPortaliA4QJE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S14 family.UniRule annotation

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    HAMAPiMF_00444. ClpP.
    InterProiIPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view]
    PANTHERiPTHR10381. PTHR10381. 1 hit.
    PfamiPF00574. CLP_protease. 1 hit.
    [Graphical view]
    PRINTSiPR00127. CLPPROTEASEP.
    SUPFAMiSSF52096. SSF52096. 1 hit.
    PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4QJE0-1 [UniParc]FASTAAdd to Basket

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    MPIGVPKVPF RSPGEGDTSW VDIYNRLYRE RLFFLGQEVD TDISNQLISL    50
    MIYLSIEKDT KDLYLFINSP GGWVISGMAI YDTMQFVRPD VQTICMGLAA 100
    SIASFILVGG AITKRIAFPH ARVMIHQPAS SFYEAQTGEF ILEAEELLKL 150
    RETITRVYVQ RTGKPIWVVS EDMERDVFMS ATEAQAHGIV DLVAVQ 196
    Length:196
    Mass (Da):22,070
    Last modified:May 15, 2007 - v1
    Checksum:i2A0A3FDA4EFAE709
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009366 Genomic DNA. Translation: BAF49795.1.
    RefSeqiYP_001122971.1. NC_009265.1.

    Genome annotation databases

    GeneIDi4968625.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009366 Genomic DNA. Translation: BAF49795.1 .
    RefSeqi YP_001122971.1. NC_009265.1.

    3D structure databases

    ProteinModelPortali A4QJE0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4968625.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    HAMAPi MF_00444. ClpP.
    InterProi IPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view ]
    PANTHERi PTHR10381. PTHR10381. 1 hit.
    Pfami PF00574. CLP_protease. 1 hit.
    [Graphical view ]
    PRINTSi PR00127. CLPPROTEASEP.
    SUPFAMi SSF52096. SSF52096. 1 hit.
    PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing analysis of Aethionema coridifolium chloroplast DNA."
      Hosouchi T., Tsuruoka H., Kotani H.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCLPP_AETCO
    AccessioniPrimary (citable) accession number: A4QJE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3