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A4QJE0

- CLPP_AETCO

UniProt

A4QJE0 - CLPP_AETCO

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Protein

ATP-dependent Clp protease proteolytic subunit

Gene
clpP
Organism
Aethionema cordifolium (Lebanon stonecress)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011Nucleophile By similarity
Active sitei126 – 1261 By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit (EC:3.4.21.92)
Alternative name(s):
Endopeptidase Clp
Gene namesi
Name:clpP
Encoded oniPlastid; Chloroplast
OrganismiAethionema cordifolium (Lebanon stonecress)
Taxonomic identifieri434059 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeAethionemeaeAethionema

Subcellular locationi

Plastidchloroplast stroma By similarity UniRule annotation

GO - Cellular componenti

  1. chloroplast stroma Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196ATP-dependent Clp protease proteolytic subunitUniRule annotationPRO_0000309286Add
BLAST

Interactioni

Subunit structurei

Component of the chloroplastic Clp protease core complex.

Structurei

3D structure databases

ProteinModelPortaliA4QJE0.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QJE0-1 [UniParc]FASTAAdd to Basket

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MPIGVPKVPF RSPGEGDTSW VDIYNRLYRE RLFFLGQEVD TDISNQLISL    50
MIYLSIEKDT KDLYLFINSP GGWVISGMAI YDTMQFVRPD VQTICMGLAA 100
SIASFILVGG AITKRIAFPH ARVMIHQPAS SFYEAQTGEF ILEAEELLKL 150
RETITRVYVQ RTGKPIWVVS EDMERDVFMS ATEAQAHGIV DLVAVQ 196
Length:196
Mass (Da):22,070
Last modified:May 15, 2007 - v1
Checksum:i2A0A3FDA4EFAE709
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009366 Genomic DNA. Translation: BAF49795.1.
RefSeqiYP_001122971.1. NC_009265.1.

Genome annotation databases

GeneIDi4968625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009366 Genomic DNA. Translation: BAF49795.1 .
RefSeqi YP_001122971.1. NC_009265.1.

3D structure databases

ProteinModelPortali A4QJE0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4968625.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing analysis of Aethionema coridifolium chloroplast DNA."
    Hosouchi T., Tsuruoka H., Kotani H.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCLPP_AETCO
AccessioniPrimary (citable) accession number: A4QJE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 15, 2007
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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