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A4QJE0

- CLPP_AETCO

UniProt

A4QJE0 - CLPP_AETCO

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Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Aethionema cordifolium (Lebanon stonecress)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011NucleophileUniRule annotation
Active sitei126 – 1261UniRule annotation

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase ClpUniRule annotation
Gene namesi
Name:clpPUniRule annotation
Encoded oniPlastid; Chloroplast
OrganismiAethionema cordifolium (Lebanon stonecress)
Taxonomic identifieri434059 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeAethionemeaeAethionema

Subcellular locationi

Plastidchloroplast stroma UniRule annotation

GO - Cellular componenti

  1. chloroplast stroma Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196ATP-dependent Clp protease proteolytic subunitPRO_0000309286Add
BLAST

Interactioni

Subunit structurei

Component of the chloroplastic Clp protease core complex.

Structurei

3D structure databases

ProteinModelPortaliA4QJE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QJE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPIGVPKVPF RSPGEGDTSW VDIYNRLYRE RLFFLGQEVD TDISNQLISL
60 70 80 90 100
MIYLSIEKDT KDLYLFINSP GGWVISGMAI YDTMQFVRPD VQTICMGLAA
110 120 130 140 150
SIASFILVGG AITKRIAFPH ARVMIHQPAS SFYEAQTGEF ILEAEELLKL
160 170 180 190
RETITRVYVQ RTGKPIWVVS EDMERDVFMS ATEAQAHGIV DLVAVQ
Length:196
Mass (Da):22,070
Last modified:May 15, 2007 - v1
Checksum:i2A0A3FDA4EFAE709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009366 Genomic DNA. Translation: BAF49795.1.
RefSeqiYP_001122971.1. NC_009265.1.

Genome annotation databases

GeneIDi4968625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009366 Genomic DNA. Translation: BAF49795.1 .
RefSeqi YP_001122971.1. NC_009265.1.

3D structure databases

ProteinModelPortali A4QJE0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4968625.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing analysis of Aethionema coridifolium chloroplast DNA."
    Hosouchi T., Tsuruoka H., Kotani H.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCLPP_AETCO
AccessioniPrimary (citable) accession number: A4QJE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3