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A4QJE0 (CLPP_AETCO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease proteolytic subunit

EC=3.4.21.92
Alternative name(s):
Endopeptidase Clp
Gene names
Name:clpP
Encoded onPlastid; Chloroplast
OrganismAethionema cordifolium (Lebanon stonecress)
Taxonomic identifier434059 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeAethionemeaeAethionema

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP-Rule MF_00444

Catalytic activity

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP-Rule MF_00444

Subunit structure

Component of the chloroplastic Clp protease core complex.

Subcellular location

Plastidchloroplast stroma By similarity HAMAP-Rule MF_00444.

Sequence similarities

Belongs to the peptidase S14 family.

Ontologies

Keywords
   Cellular componentChloroplast
Plastid
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentchloroplast stroma

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196ATP-dependent Clp protease proteolytic subunit HAMAP-Rule MF_00444
PRO_0000309286

Sites

Active site1011 By similarity
Active site1261 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QJE0 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 2A0A3FDA4EFAE709

FASTA19622,070
        10         20         30         40         50         60 
MPIGVPKVPF RSPGEGDTSW VDIYNRLYRE RLFFLGQEVD TDISNQLISL MIYLSIEKDT 

        70         80         90        100        110        120 
KDLYLFINSP GGWVISGMAI YDTMQFVRPD VQTICMGLAA SIASFILVGG AITKRIAFPH 

       130        140        150        160        170        180 
ARVMIHQPAS SFYEAQTGEF ILEAEELLKL RETITRVYVQ RTGKPIWVVS EDMERDVFMS 

       190 
ATEAQAHGIV DLVAVQ 

« Hide

References

[1]"Sequencing analysis of Aethionema coridifolium chloroplast DNA."
Hosouchi T., Tsuruoka H., Kotani H.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009366 Genomic DNA. Translation: BAF49795.1.
RefSeqYP_001122971.1. NC_009265.1.

3D structure databases

ProteinModelPortalA4QJE0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4968625.

Phylogenomic databases

ProtClustDBCHL00028.

Family and domain databases

HAMAPMF_00444. ClpP.
InterProIPR001907. ClpP.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERPTHR10381. PTHR10381. 1 hit.
PfamPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSPR00127. CLPPROTEASEP.
PROSITEPS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLPP_AETCO
AccessionPrimary (citable) accession number: A4QJE0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 15, 2007
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries