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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic

Gene

accD

Organism
Aethionema cordifolium (Lebanon stonecress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi222ZincUniRule annotation1
Metal bindingi225ZincUniRule annotation1
Metal bindingi241ZincUniRule annotation1
Metal bindingi244ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C4-typeUniRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticUniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotation
Encoded oniPlastid; Chloroplast
OrganismiAethionema cordifolium (Lebanon stonecress)
Taxonomic identifieri434059 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeAethionemeaeAethionema

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003591181 – 485Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticAdd BLAST485

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).By similarity

Structurei

3D structure databases

SMRiA4QJC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 485CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST268

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C4-typeUniRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A4QJC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSWFNFLF SKGELEYRCE LSKSMDSFAP IEKTTDRVIY DTDKNLYDWG
60 70 80 90 100
ERSSYYNNVD LLVSSKDIRN FISDDTFFVR DSNKNSYSIY FDIQNQKFEI
110 120 130 140 150
DNGLSDLEVF FYSYRSSSYL NNRSKSDNDP HYDPSIKDTK YDCNNHINSC
160 170 180 190 200
IDSYFRSHIC IDSHFLSDSK NYNESYIYNL ICSKSGKIRE SQNYKIRTNM
210 220 230 240 250
NRSDLIKDFD ITQNYNQLWI QCDNCYALIY KKALKFKMNV CEQCGYYLKI
260 270 280 290 300
SSSDRIELSI DPGTWNPMDE DMVSTDPIQF HSREEPYQNR IDSAQKKTGL
310 320 330 340 350
TDAVQTGTGQ LNGIPVALGV MDFQFMGGSM GSVVGEKITR LIEYATTEFL
360 370 380 390 400
PLILVCSSGG ARMQEGSLSL MQMAKISSVL CDYQSSKKLF YISILTSPTT
410 420 430 440 450
GGVTASFGML GDIIIAEPYA YIAFAGKRVI EQTLKKAVPE GSQAAESLLR
460 470 480
KGLLDAIVPR NPLKGVLTEL FQLHAFFPLN KNEIK
Length:485
Mass (Da):55,383
Last modified:May 15, 2007 - v1
Checksum:i78BBDF2BB9E115DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009366 Genomic DNA. Translation: BAF49779.1.
RefSeqiYP_001122955.1. NC_009265.1.

Genome annotation databases

GeneIDi4968663.

Similar proteinsi

Entry informationi

Entry nameiACCD_AETCO
AccessioniPrimary (citable) accession number: A4QJC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 15, 2007
Last modified: November 22, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families