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A4QI59

- SYL_CORGB

UniProt

A4QI59 - SYL_CORGB

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium glutamicum (strain R)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei725 – 7251ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCGLU340322:GJBE-3041-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:cgR_2905
OrganismiCorynebacterium glutamicum (strain R)
Taxonomic identifieri340322 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000006698: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Leucine--tRNA ligasePRO_1000009333Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340322.cgR_2905.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7712"HIGH" regionAdd
BLAST
Motifi722 – 7265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4QI59 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNPSEGTTP LAFRYTPELA NKIEGEWQNY WTDNGTFNAP NPVGDLAPAD
60 70 80 90 100
GKALPEDKLF VQDMFPYPSG AGLHVGHPLG YIATDVFARY NRMLGKNVLH
110 120 130 140 150
TLGYDAFGLP AEQYAIQTGT HPRTTTMANI ENMKRQLGAL GLGHDSRRAV
160 170 180 190 200
ATTDPEFYKW TQWIFLQIFN SWFDAEQQKA RPISELIPLL ESGELKTKDG
210 220 230 240 250
ADYNALGDVE KQKAVDDYRL VYRSNSTVNW CPGLGTVLAN EEVTADGRSE
260 270 280 290 300
RGNFPVFRKN LSQWMMRITA YSDRLIDDLE LLDWTEKVKS MQRNWIGRSR
310 320 330 340 350
GAEVDFSAEG ETVTVFTTRP DTLFGATYMV LAPEHELVDV LLEKAGSYEG
360 370 380 390 400
VDARWTNGQA SPAEAVAAYR ASIAAKSDLE RQENKEKTGV FLGVYATNPV
410 420 430 440 450
NGDQIPVFIA DYVLTGYGTG AIMAVPAHDE RDYEFATVLG LPIKEVVAGG
460 470 480 490 500
NIEEAAFTES GEAVNSANDN GLDINGLAKD EAVAKTIEWL EEKELGRGTI
510 520 530 540 550
QYKLRDWLFA RQRYWGEPFP IVYDENGQAH ALPDSMLPVE LPEVEDYKPV
560 570 580 590 600
SFDPEDADSE PSPPLAKARE WVEVELDLGD GKKKYTRDTN VMPQWAGSSW
610 620 630 640 650
YQLRYVDPSN DEQFCNIENE RYWTGPRPET HGPNDPGGVD LYVGGVEHAV
660 670 680 690 700
LHLLYARFWH KVLFDLGHVS SKEPYRRLYN QGYIQAFAYT DSRGVYVPAD
710 720 730 740 750
DVEEKDGKFF YQGEEVNQEY GKMGKSLKNA VAPDDICNNF GADTLRVYEM
760 770 780 790 800
AMGPLDTSRP WATKDVVGAQ RFLQRLWRLV VDENTGEVLT RDEVLTDDDN
810 820 830 840 850
KQLHRTIAGV RDDYTNLRVN TVVAKLIEYV NYLTKTYPDT IPAGAVLPLI
860 870 880 890 900
VMVSPVAPHI AEELWKKLGH DDTVTYEPFP TFEEKWLTDD EIELPVQVNG
910 920 930 940 950
KVRGRITVAA DASQEQVIEA ALADEKVQEQ ISGKNLIKQI VVPGRMVNLV

VK
Length:952
Mass (Da):106,747
Last modified:May 15, 2007 - v1
Checksum:iCA1A789CF8EAE151
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009044 Genomic DNA. Translation: BAF55925.1.
RefSeqiYP_001139827.1. NC_009342.1.

Genome annotation databases

EnsemblBacteriaiBAF55925; BAF55925; cgR_2905.
GeneIDi4993659.
KEGGicgt:cgR_2905.
PATRICi21510514. VBICorGlu58097_2975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009044 Genomic DNA. Translation: BAF55925.1 .
RefSeqi YP_001139827.1. NC_009342.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340322.cgR_2905.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF55925 ; BAF55925 ; cgR_2905 .
GeneIDi 4993659.
KEGGi cgt:cgR_2905.
PATRICi 21510514. VBICorGlu58097_2975.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CGLU340322:GJBE-3041-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
    Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
    Microbiology 153:1042-1058(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R.

Entry informationi

Entry nameiSYL_CORGB
AccessioniPrimary (citable) accession number: A4QI59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3