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A4QHT1 (GLPK_CORGB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:cgR_2778
OrganismCorynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]
Taxonomic identifier340322 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Glycerol kinase HAMAP MF_00186
PRO_1000020724

Regions

Nucleotide binding423 – 4275ATP By similarity

Sites

Binding site171Substrate By similarity
Binding site211ATP By similarity
Binding site871Substrate By similarity
Binding site1391Substrate By similarity
Binding site2561Substrate By similarity
Binding site2781ATP By similarity
Binding site3221ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A4QHT1 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: EC8B65618D84C480

FASTA50956,145
        10         20         30         40         50         60 
MRISKANAYV AAIDQGTTST RCIFIDAQGK VVSSASKEHR QIFPQQGWVE HDPEEIWDNI 

        70         80         90        100        110        120 
RSVVSQAMVS IDITPHEVAS LGVTNQRETT VVWDKHTGEP VYNAIVWQDT RTSDICLEIA 

       130        140        150        160        170        180 
GEEGQEKWLD RTGLLINSYP SGPKIKWILD NVEGARERAE KGDLLFGTMD TWVLWNLTGG 

       190        200        210        220        230        240 
VRGDDGDDAI HVTDVTNASR TLLMDLRTQQ WDPELCEALD IPMSMLPEIR PSVGEFRSVR 

       250        260        270        280        290        300 
HRGTLADVPI TGVLGDQQAA LFGQGGFHEG AAKNTYGTGL FLLMNTGTSL KISEHGLLST 

       310        320        330        340        350        360 
IAYQREGSAP VYALEGSVSM GGSLVQWLRD NLQLIPNAPA IENLAREVED NGGVHVVPAF 

       370        380        390        400        410        420 
TGLFAPRWRP DARGVITGLT RFANRKHIAR AVLEANAFQT REVVDAMAKD AGKALESLRV 

       430        440        450        460        470        480 
DGAMVENDLL MQMQADFLGI DVQRLEDVET TAVGVAFAAG LGSGFFKTTD EIEKLIAVKK 

       490        500 
VWNPDMSEEE RERRYAEWNR AVEHSYDQA

« Hide

References

[1]"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009044 Genomic DNA. Translation: BAF55797.1.
RefSeqYP_001139699.1. NC_009342.1.

3D structure databases

ProteinModelPortalA4QHT1.
SMRA4QHT1. Positions 8-506.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4QHT1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4993458.
GenomeReviewsGene locus cgR_2778 in contig AP009044_GR.
KEGGcgt:cgR_2778.
PATRIC21510248. VBICorGlu58097_2845.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0554.
HOGENOMHBG511469.
OMAATYFSGT.
ProtClustDBPRK00047.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_CORGB
AccessionPrimary (citable) accession number: A4QHT1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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