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A4QGY2 (A4QGY2_CORGB) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Ordered Locus Names:cgR_2487
OrganismCorynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]
Taxonomic identifier340322 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site201For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2591Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4051Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4631Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4661Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
A4QGY2 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: B0DCF2878828298C

FASTA49452,878
        10         20         30         40         50         60 
MTQVNHPYDD LNEQAPQEEC GVFGVWAPGE EVSKLTYFGL FALQHRGQEA AGIAVGDGEQ 

        70         80         90        100        110        120 
ILVFKDLGLV SQVFDEPILE SLRGNIAIGH TRYTTAGGNT WENAQPMFRM APDGTDIALG 

       130        140        150        160        170        180 
HNGNLINYIE LLDKATELGL VDPAEKPSDT DVLTGLLASG VHDGKSLFDS AKELLPSVKG 

       190        200        210        220        230        240 
AYCLTFTDGH TLYAARDPFG IRPLSIGRLE RGWVVASETA ALDIVGASHV REVEPGELIA 

       250        260        270        280        290        300 
IDESGLKSAR FAETTRKGCV FEYVYLARPD SVIKGRNVNE ARLEIGRKLA AEAPAVGDLV 

       310        320        330        340        350        360 
IPTPESGTPA AVGFAQASGI PFGQGMVKNA YVGRTFIQPS DTLRQLGIRL KLNPLREVIA 

       370        380        390        400        410        420 
GKRLVVVDDS IVRGNTQRAV IRMLREAGAA EVHVRIASPP VKWPCFYGID FATPGELIAN 

       430        440        450        460        470        480 
AVTSDNEAEM VEAVRSAIGA DTLGYVSIDS MIAATEQPAN ELCIACFDGK YPMGLPQGNS 

       490 
NADLVRKMQA TASS

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References

[1]"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009044 Genomic DNA. Translation: BAF55498.1.
RefSeqYP_001139400.1. NC_009342.1.

3D structure databases

ProteinModelPortalA4QGY2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4QGY2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4994360.
GenomeReviewsGene locus cgR_2487 in contig AP009044_GR.
KEGGcgt:cgR_2487.
PATRIC21509654. VBICorGlu58097_2550.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0034.
HOGENOMHBG392416.
OMAVWAPGEE.
ProtClustDBPRK07847.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4QGY2_CORGB
AccessionPrimary (citable) accession number: A4QGY2
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info