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A4QFV6 (A4QFV6_CORGB) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Ordered Locus Names:cgR_2120
OrganismCorynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]
Taxonomic identifier340322 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length922 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
A4QFV6 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 29C58E77DD4F5C57

FASTA922102,858
        10         20         30         40         50         60 
MADQAKLGGK PSDDSNFAMI RDGVASYLND SDPEETNEWM DSLDGLLQES SPERARYLML 

        70         80         90        100        110        120 
RLLERASAKR VSLPPMTSTD YVNTIPTSME PEFPGDEEME KRYRRWIRWN AAIMVHRAQR 

       130        140        150        160        170        180 
PGIGVGGHIS TYAGAAPLYE VGFNHFFRGK DHPGGGDQIF FQGHASPGMY ARAFMEGRLS 

       190        200        210        220        230        240 
EDDLDGFRQE VSREQGGIPS YPHPHGMKDF WEFPTVSMGL GPMDAIYQAR FNRYLENRGI 

       250        260        270        280        290        300 
KDTSDQHVWA FLGDGEMDEP ESRGLIQQAA LNNLDNLTFV VNCNLQRLDG PVRGNTKIIQ 

       310        320        330        340        350        360 
ELESFFRGAG WSVIKVVWGR EWDELLEKDQ DGALVEIMNN TSDGDYQTFK ANDGAYVREH 

       370        380        390        400        410        420 
FFGRDPRTAK LVENMTDEEI WKLPRGGHDY RKVYAAYKRA LETKDRPTVI LAHTIKGYGL 

       430        440        450        460        470        480 
GHNFEGRNAT HQMKKLTLDD LKLFRDKQGI PITDEQLEKD PYLPPYYHPG EDAPEIKYMK 

       490        500        510        520        530        540 
ERRAALGGYL PERRENYDPI QVPPLDKLRS VRKGSGKQQI ATTMATVRTF KELMRDKGLA 

       550        560        570        580        590        600 
DRLVPIIPDE ARTFGLDSWF PTLKIYNPHG QNYVPVDHDL MLSYREAPEG QILHEGINEA 

       610        620        630        640        650        660 
GSMASFIAAG TSYATHGKAM IPLYIFYSMF GFQRTGDSIW AAADQMARGF LLGATAGRTT 

       670        680        690        700        710        720 
LTGEGLQHMD GHSPVLASTN EGVETYDPSF AYEIAHLVHR GIDRMYGPGK GEDVIYYITI 

       730        740        750        760        770        780 
YNEPTPQPAE PEGLDVEGLH KGIYLYSRGE GTGHEANILA SGVGMQWALK AASILEADYG 

       790        800        810        820        830        840 
VRANIYSATS WVNLARDGAA RNKAQLRNPG ADAGEAFVTT QLKQTSGPYV AVSDFSTDLP 

       850        860        870        880        890        900 
NQIREWVPGD YTVLGADGFG FSDTRPAARR FFNIDAESIV VAVLNSLARE GKIDVSVAAQ 

       910        920 
AAEKFKLDDP TSVSVDPNAP EE

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References

[1]"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R."
Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.
Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009044 Genomic DNA. Translation: BAF55122.1.
RefSeqYP_001139024.1. NC_009342.1.

3D structure databases

ProteinModelPortalA4QFV6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4QFV6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4994344.
GenomeReviewsGene locus cgR_2120 in contig AP009044_GR.
KEGGcgt:cgR_2120.
PATRIC21508878. VBICorGlu58097_2184.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2609.
HOGENOMHBG289271.
OMAFRQEKSH.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4QFV6_CORGB
AccessionPrimary (citable) accession number: A4QFV6
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info