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Protein

Adenosylcobinamide-GDP ribazoletransferase

Gene

cobS

Organism
Corynebacterium glutamicum (strain R)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.UniRule annotation

Catalytic activityi

Adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin.UniRule annotation
Adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate = GMP + adenosylcobalamin 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. Adenosylcobinamide-GDP ribazoletransferase (cobS)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCobalamin biosynthesis
LigandMagnesium

Enzyme and pathway databases

BioCyciCGLU340322:G1G2L-2195-MONOMER
UniPathwayiUPA00148; UER00238

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobinamide-GDP ribazoletransferaseUniRule annotation (EC:2.7.8.26UniRule annotation)
Alternative name(s):
Cobalamin synthaseUniRule annotation
Cobalamin-5'-phosphate synthaseUniRule annotation
Gene namesi
Name:cobSUniRule annotation
Ordered Locus Names:cgR_2082
OrganismiCorynebacterium glutamicum (strain R)
Taxonomic identifieri340322 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000006698 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Transmembranei58 – 78HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 157HelicalUniRule annotationAdd BLAST21
Transmembranei161 – 181HelicalUniRule annotationAdd BLAST21
Transmembranei212 – 232HelicalUniRule annotationAdd BLAST21
Transmembranei248 – 268HelicalUniRule annotationAdd BLAST21
Transmembranei283 – 303HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000457671 – 307Adenosylcobinamide-GDP ribazoletransferaseAdd BLAST307

Proteomic databases

PRIDEiA4QFR6

Family & Domainsi

Sequence similaritiesi

Belongs to the CobS family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000228087
KOiK02233
OMAiVIVALWE
OrthoDBiPOG091H02RG

Family and domain databases

HAMAPiMF_00719 CobS, 1 hit
InterProiView protein in InterPro
IPR003805 CobS
PANTHERiPTHR34148 PTHR34148, 1 hit
PfamiView protein in Pfam
PF02654 CobS, 1 hit

Sequencei

Sequence statusi: Complete.

A4QFR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKAGFTPE DPEDSDNRHG SPLFEGIFTA LNWMTVLPVP GASVFDRTTG
60 70 80 90 100
ARVMASLPFV GFVFGMFTAI IMWAIGPISG VIHVDGLLVA VLIVAFWELL
110 120 130 140 150
NRFMHLDGLA DVSDALGSYA APPRAREILA DPRTGLFGLA TAMLSVLVQV
160 170 180 190 200
AAVASLVDST VWWMICFIPV LGRIAGQVTA LKNHHAFSPT GFGALVIGTV
210 220 230 240 250
KFWWIALWLL VTPALAFWCA ELISPLSPLT SVNTPFVAGP FPAAINPAWL
260 270 280 290 300
GGWVAITAVV ACVFAALFSR RLSRSFGGLN GDCIGACIHL GASISAVMLA

VVANAMV
Length:307
Mass (Da):32,410
Last modified:May 15, 2007 - v1
Checksum:i902B73CA5592CAEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009044 Genomic DNA Translation: BAF55082.1
RefSeqiWP_011897590.1, NC_009342.1

Genome annotation databases

EnsemblBacteriaiBAF55082; BAF55082; cgR_2082
KEGGicgt:cgR_2082

Similar proteinsi

Entry informationi

Entry nameiCOBS_CORGB
AccessioniPrimary (citable) accession number: A4QFR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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