A4QFN6 (A4QFN6_CORGB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

cgR_2053

Organism

Corynebacterium glutamicum (strain R) [Complete proteome] [HAMAP]

Taxonomic identifier

340322 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4QFN6 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 8DEF8384DE8271F4	FASTA	349	38,878
	10 20 30 40 50 60 MVGVNKCQRQ SQQNTFITLR YPGMSLTNIP ASSQWAISDV LKRPSPGRVP FSVEFMPPRD 70 80 90 100 110 120 DAAEERLYRA AEVFHDLGAS FVSVTYGAGG STRERTSRIA RRLAKQPLTT LVHLTLVNHT 130 140 150 160 170 180 REEMKAILRE YLELGLTNLL ALRGDPPGDP LGDWVSTDGG LNYASELIDL IKSTPEFREF 190 200 210 220 230 240 DLGIASFPEG HFRAKTLEED TKYTLAKLRG GAEYSITQMF FDVEDYLRLR DRLVAADPIH 250 260 270 280 290 300 GAKPIIPGIM PITSLRSVRR QVELSGAQLP SQLEESLVRA ANGNEEANKD EIRKVGIEYS 310 320 330 340 TNMAERLIAE GAEDLHFMTL NFTRATQEVL YNLGMAPAWG AEHGQDAVR

References

[1]

"Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R." Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M., Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M. Microbiology 153:1042-1058(2007) [PubMed: 17379713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: R.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009044 Genomic DNA. Translation: BAF55052.1.
RefSeq	YP_001138954.1. NC_009342.1.
3D structure databases
ProteinModelPortal	A4QFN6.
ModBase	Search...
Protein-protein interaction databases
STRING	A4QFN6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4991605.
GenomeReviews	Gene locus cgR_2053 in contig AP009044_GR.
KEGG	cgt:cgR_2053.
PATRIC	21508740. VBICorGlu58097_2116.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0685.
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK638719.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A4QFN6_CORGB

Accession

Primary (citable) accession number: A4QFN6

Entry history

Integrated into UniProtKB/TrEMBL:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)